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Body fat distribution is a heritable trait and a well-established predictor of adverse metabolic outcomes, independent of overall adiposity. To increase our understanding of the genetic basis of body fat distribution and its molecular links to cardiometabolic traits, here we conduct genome-wide association meta-analyses of traits related to waist and hip circumferences in up to 224,459 individuals
Previous studies have suggested that dietary factors may be important in the development of bladder cancer. We examined macronutrient intake in relation to risk of urothelial cell carcinoma among 469,339 men and women in the European Prospective Investigation into Cancer and Nutrition. Associations were examined using Cox regression, stratified by sex, age at recruitment and centre and further adj
Most forms of contemporary preaching elevate the role of the listeners, who are seen as co-constructors of the sermon. This article investigates how preachers may respond to a call from homiletics to 'turn-to-the-listener' through their deployment of metadiscourse, operationalized as a framework for understanding preaching not primarily as gospel proclamation, but as a form of social and communica
UV-B radiation (280–315 nm) is an integral part of solar radiation and has many harmful effects on plant growth and development. However, the molecular mechanism for the inhibition of plant growth by UV-B remains largely unknown. UV-B radiation induces various responses such as growth inhibition, DNA damage and changes of gene expression. Recently, by using synchronous root tip culture, we found t
Background There is currently no standardized process for long-term follow-up care. As a result, management of post-stroke care varies greatly, and the needs of stroke survivors are not fully addressed. The Post Stroke Checklist was developed by the Global Stroke Community Advisory Panel as a means of standardizing long-term stroke care. Since its development, the Post Stroke Checklist has gained
Abstract in Undetermined Assume that in periods with stochastic demand remain until the next replenishment arrives at a central warehouse. How should the available inventory be allocated among N retailers? This paper presents a new policy and a new lower bound for the expected cost of this problem. The lower bound becomes tight as N -> infinity. The infinite horizon problem then decomposes into N
Previous studies have reported an association between exercise during youth and increased areal bone mineral density at old age. The primary aim of this study was to investigate if exercise during growth was independently associated with greater cortical bone size and whole bone strength in weight-bearing bone in old men. The tibia and radius were measured using both peripheral quantitative comput
In a corner of the Egyptian revolutionary drama, the fisherfolk of the northern Nile Delta have begun to organise. They suffer an indicative predicament. The two great lagoons of Borullus and Manzala have largely been enclosed by fish farms as the Mubarak regime sought to expand Egypt's aquaculture industry. On the other hand, the sea is threatening to submerge the ground on which the very same fi
Type 1 diabetes mellitus (T1DM) is an autoimmune disorder directed against the β cells of the pancreatic islets. The genetic risk of the disease is linked to HLA-DQ risk alleles and unknown environmental triggers. In most countries, only 10-15% of children or young adults newly diagnosed with T1DM have a first-degree relative with the disease. Autoantibodies against insulin, GAD65, IA-2 or the ZnT
Non-stretched laminar burning velocities, SL, of acetaldehyde + air mixtures at initial gas mixture temperatures, T, of 298, 318, 338, 348 and 358 K are reported for the first time. The flames were stabilized on a perforated plate burner at 1 atm using the heat flux method at conditions where the net heat loss from the flame to the burner is zero. Uncertainties of the measurements were analyzed an
Several psychiatric disorders may be characterized by peripheral telomere shortening. However, it is unclear whether telomere shortening is associated with these psychiatric disorders per se or, rather, with underlying dimensional parameters that are often, but not necessarily, associated with them. We explored the association between dimensional psychopathological measures and telomere length (TL
International guidelines advocate an implantable cardioverter and defibrillator (ICD) in patients with reduced left ventricular ejection fraction (LVEF) to prevent sudden death (SCD). Previous data suggest that the benefit of ICD therapy in real life may be lower than expected from the results of controlled studies and side-effects are not negligible. It is also unclear whether women benefit from
Municipal solid waste is one of the major environmental problems in Jordan. The World Bank visibility study (2004) showed that the rate of production of solid waste in Jordan was estimated annually of about 1.46 million ton, and is expected to reach 2.5 million ton by the year 2015 with a generation of 0.9/kg/capita/day. This solid waste volume is still increasing at high rates due to the rapid in
This paper describes measurements of the sum of the transverse energy of particles as a function of particle pseudorapidity, eta, in proton-proton collisions at a centre-of-mass energy, root s = 7 TeV using the ATLAS detector at the Large Hadron Collider. The measurements are performed in the region \eta\ < 4.8 for two event classes: those requiring the presence of particles with a low transverse
The objective was to describe pregnancy outcomes in gestational diabetes mellitus (GDM) in comparison with general population in Sweden.
Genetic, transcript, and protein level variations have important functional and evolutionary consequences. We performed systematic data collection and analysis of copy-number variations, single-nucleotide polymorphisms, disease-causing variations, messenger RNA splicing variants, and protein posttranslational modifications for the genes and proteins essential for human immune system. Information a
Although bone marrow derived mesenchymal stem cell (MSC) systemic administration reduces sepsis-associated inflammation, organ injury, and mortality in clinically relevant models of polymicrobial sepsis, the cellular and molecular mechanisms mediating beneficial effects are controversial. This study identifies the molecular mechanisms of MSC-conferred protection in sepsis by interrogating transcri
Background:The objective was to analyze the association between neighborhood deprivation and prostate cancer mortality, after adjusting for individual characteristics.Methods:This study was designed as a follow-up study of prostate cancer mortality between 1 January 1990 and 31 December 2008 in patients aged 25-74 years (a total of 73 159 patients). Multilevel logistic regression analyses were per
