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Although free radicals have been suggested to contribute to ischemic brain damage for more than 10 years, it is not until quite recently that convincing evidence has been presented for their involvement in both sustained and transient ischemia. The hypothesis is examined against current knowledge of free radical chemistry, as it applies to biological systems, and of cellular iron metabolism. It is
Exposure to methylene chloride produced a time and concentration related increase in liver weight. The effect was more prominent in female mice than in male. The activity of plasma butyrylcholinesterase (BuChE) increased even more than the liver weight at corresponding exposures, but only in the males. Fatty infiltration was noticeable after exposure to 75 p.p.m. and was more prominent in the fema
We investigate the three-neutrino mixing scheme for solving the atmospheric and LSND anomalies. We find the region in the parameter space that provides a good fit to the LSND and the SK atmospheric data, taking into account the CHOOZ constraint. We demonstrate that the goodness of this fit is comparable to that of the conventional fit to the solar and atmospheric data. Large values of the LSND ang
Elimination of all animal material during both the derivation and long-term culture of human embryonic stem cells (hESCs) is necessary prior to future application of hESCs in clinical cell therapy. The potential consequences of transplanting xeno-contaminated hESCs into patients, such as an increased risk of graft rejection [STEM CELLS 2006;24:221229] and the potential transfer of nonhuman pathoge
This review summarizes experimental findings that highlight the complex roles of the immune system in atherogenesis. Immune activation can have either proatherogenic or atheroprotective effects. Immune-modulation therapy via an active or passive immunization strategy aims to exploit the atheroprotective aspects of the immune system to modulate atherosclerosis. Several experimental studies have dem
Novel non-thiazolidinedione, tyrosine-derived peroxisome proliferator-activated receptor gamma agonists, GI 262570, GW 7845, GW 1929, developed by Glaxo-Smith-Kline (GSK) along with pioglitazone and nisoldipine, were studied on currents through L-type voltage-dependent calcium channels (VDCC) in freshly isolated smooth muscle cells from mesenteric arteries, and on the diameter of pressurized mesen
OBJECTIVE: To examine the concept of selective superior and inferior vestibular nerve involvement in vestibular neuritis by studying the distribution of semicircular canal (SCC) involvement in such patients. BACKGROUND: Vestibular neuritis was traditionally thought to involve the superior and inferior vestibular nerves. Recent work suggests that in some patients, only the superior nerve is involve
In the neutral title complex, [Cu(C3H2O4)(C5H8N2)(2-)(H2O)]. 2H(2)O or [Cu(mal)(dmp)(2)(H2O)]. 2H(2)O (mal is malonate and dmp is 3,5-dimethyl-1H-pyrazole), the Cu-II ion, in a slightly distorted square-pyramidal geometry, is coordinated by two O atoms of the bidentate malonate, the O atom of the water ligand and two N atoms from the two 3,5-dimethylpyrazole ligands. The mean Cu-N bond length is 2
Day care is currently a common way of providing treatment for minor and average paediatric surgical procedures. The purpose of this study was to assess possible benefits of increasing parental involvement in the care of operated children in a day-care surgery unit. By giving parents information and education about post-operative care, the goal was to facilitate recovery and minimize time spent in
In the insulin-secreting beta-cell line beta TC3, stimulation with 11.2 mmol/l glucose caused a rise in the intracellular free Ca2+ concentration ([Ca2+]i) in only 18% of the tested cells. The number of glucose-responsive cells increased after pretreatment of the cells with glucagon-like peptide I (GLP-I)(7-36)amide and at 10(-11) mol/l; 84% of the cells responded to glucose with a rise in [Ca2+]i
Popular Abstract in Swedish Syftet med arbetet är att undersöka och påvisa hur ett bostadshus kan projekteras så att funktionen på bästa sätt motsvarar de krav som ställs, till lägsta möjliga kostnad och miljöpåverkan över hela livscykeln. Såväl metodiken för helhetsprojektering, som byggnadens specifika egenskaper och funktioner studeras. Metodiken som utvecklas är generell, medan tillämpningen, The objective of this work is to explore ways of enhancing the overall lifetime quality, including cost and environmental efficiency, of Swedish concrete multi-dwelling buildings. The building and its characteristics, as well as the procedures for whole life optimisation, are addressed. The methods developed are general for buildings, while the application is specific. The fundamental characteris
The diagnosis and prognosis for 135 women with breast cancer and 99 women with ovarian cancer in a well-defined geographical area, and a follow-up of 7-15 years are described, based on patients' records. Diagnosis was initiated in primary care for 53% of women with breast cancer, and for 57% of women with ovarian cancer. Median patient delay was 1 week for breast cancer, and 3.5 weeks for ovarian
Avian sex determination is chromosomal; however, the underlying mechanisms are not yet understood. There is no conclusive evidence for either of two proposed mechanisms: a dominant genetic switch or a dosage mechanism. No dominant sex-determining gene on the female-specific W chromosome has been found. Birds lack inactivation of one of the Z chromosomes in males, but seem to compensate for a doubl
The opening article of this issue is intended to provide a review of some relevant topics of the mathematical theory of water waves that have recently received considerable attention in the research literature. We also provide a brief discussion about the content and contribution of the articles that make up this issue.
Bone remodeling involves old bone resorption by osteoclasts and new bone formation by osteoblasts. However, the precise cellular mechanisms underlying these consecutive events remain obscure. To address this question in vitro, we have established a cell culture model in which the resorption lacunae are first created by osteoclasts and osteoblast-like cells accomplish the subsequent bone formation.
The activity of titania based copper and platinum monolithic catalysts in the reduction of nitrogen oxides was studied with exhaust gases from a Diesel engine injecting fuel as reductant. Combining both catalysts, a two-stage system was designed, studying the influence of the copper catalysts composition on its performance with synthetic gas mixtures. The influence of reactants concentration and o
