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The aggregation and accumulation of pathologic forms of the microtubule-associated tau protein into fibrils, eventually forming characteristic tangle pathology, hallmarks the majority of all dementia disorders which constitute the most prevalent family of neurodegenerative disorders. These so-called tauopathies are difficult to identify and diagnose, especially at early disease stages. The relativ
Objective: This study aims to provide a deeper understanding of what persons with lived experience and professionals with experience of patient safety, suicide research, and investigations consider to be most important in investigations of healthcare before suicide to learn and improve the care of suicidal patients. Method: This is a qualitative study based on 15 semistructured interviews with per
Enzymes are the quintessential green catalysts, but realizing their full potential for biotechnology typically requires improvement of their biomolecular properties. Catalysis enhancement, however, is often accompanied by impaired stability. Here, we show how the interplay between activity and stability in enzyme optimization can be efficiently addressed by coupling two recently proposed methodolo
The concept of high-risk plaque emerged from pathologic and epidemiologic studies 3 decades ago that demonstrated plaque rupture with thrombosis as the predominant mechanism of acute coronary syndrome and sudden cardiac death. Thin-cap fibroatheroma, a plaque with a large lipidic core covered by a thin fibrous cap, is the prototype of the rupture-prone plaque and has been traditionally defined as
Plain Language Summary: What is the study about? Hemophilia A is a genetic bleeding disorder that causes bleeding for long periods because of lower than normal levels of factor VIII (FVIII), a protein that is important for blood clotting. FVIII replacement therapy is the typical approach to manage bleeds, but new and improved therapies are becoming widely available. Prophylaxis with the medication
Food safety is a public health concern worldwide due to an increased morbidity and mortality risk associated with the outbreak of food-borne diseases. This study aimed to assess knowledge, attitude, and food safety practices (KAP) among university students in northern Tanzania. This is interesting because it allows data to be collected for creating awareness on safety, sanitation, and quality of f
In response to the growing problems with e-scooter parking, Sweden introduced a comprehensive change in regulations concerning e-scooter parking regulation in September 2022. This study investigates the impact of these regulatory changes on e-scooter parking behaviour in Lund and Malmö, Sweden. Using Getis-Ord G∗hotspot analysis, we identified shifts in e-scooter parking patterns pre- and post-reg
Background: In this study, we further developed an artificial intelligence (AI)-based method for the detection and quantification of tumours in the prostate, lymph nodes and bone in prostate-specific membrane antigen (PSMA)-targeting positron emission tomography with computed tomography (PET–CT) images. Methods: A total of 1064 [18F]PSMA-1007 PET–CT scans were used (approximately twice as many com
Purpose of review Myocardial infarction survivors are at a high risk of a recurrent event despite receiving guideline preventive therapy. There is accumulated evidence that persistent atherosclerotic plaque inflammation contributes to this risk. Oxidized low-density lipoprotein (LDL) is widely recognized as a key factor in plaque inflammation and instability; however, no therapies that directly ta
Background During the last decade, evidence has emerged on selective glomerular hypofiltration syndromes (SGHS), defined by selectively reduced filtration of middle-sized molecules irrespective of kidney function and resulting in a low ratio between cystatin C- and creatinine-based estimated glomerular filtration rates (eGFRcys/eGFRcr). We aimed to examine whether SGHS is a hallmark of premature k
EVs increase demand for critical raw materials (CRMs). Many of the CRMs are mined in just a handful of countries, raising security concerns among business and policymakers. Lithium is particularly precarious due to its high geographic supply concentration, high demand growth rate and few near term substitutes. This study conducts a bottom-up assessment of European lithium extraction projects. The
Bone contains diverse structures. In fast-growing large animals, fibrolamellar bone is formed first and is then gradually replaced by remodelled bone with secondary osteons. Using position-resolved X-ray diffraction and X-ray fluorescence as a 2D multimodal microscopy technique, the nature of biomineral nanocrystals is investigated in bovine bone. Systematic spatial variations are found, for examp
This study explores the informal and formal collaboration networks of teachers in the United States and Sweden, focusing on how teachers construct their professional ego networks of trusted individuals for collaboration. Using Ecological Systems Theory (EST) with an emphasis on the microsystem, the research investigates how teacher ego networks are shaped by factors like experience, access to subj
We present a Raman study of axially heterostructured InP/InGaP nanowires (NWs) for tandem solar cells. The study is carried out using both microRaman spectroscopy (µ-Raman), and tip enhanced Raman spectroscopy (TERS). The results obtained by both methods are compared. The results obtained with each one is supported by the simulation of the light/NW interaction using finite element methods. This si
The ecological conditions show synchronous differences between southern and northern Sweden, due to the delayed immigration of flora and fauna in such a long, narrow country. One of the first forest animals to immigrate was the elk. It was also among the first to disappear from southern Sweden. Mattock-heads made from elk antlers have been found in both southern and northern Sweden. In the south,
In Chapter 11, Oksana Mont and Yuliya Voytenko Palgan examine the relationship between the sharing economy and the concept of sufficiency. The chapter highlights how shared access to goods and services can change consumption patterns, maximising resource use and reducing the need for new production. This can decrease resource extraction and reduce greenhouse gas emissions. The authors discuss how
When, how and why does farming become capitalist? This question has long shaped debates in agrarian studies and economic history. Although traditional analyses emphasize market dependency and competitive pressures, this paper argues for a shift in focus towards the diverse strategies of reproduction that farmers have employed in different historical contexts. Rather than searching for common capit
The chapter describes and discusses the Nordic welfare state approach to governance of the arts using data from Sweden. It enquires into how the Swedish system for public governance of the arts works, in particular with focus on answering the question of whether public governance of the arts does secure artistic freedom, and if so how. In other words, is Swedish public governance of the arts a ben
