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Inhibition of the long non-coding RNA NEAT1 protects cardiomyocytes from hypoxia in vitro via decreased pri-miRNA processing

While restoration of coronary blood flow to the ischemic heart is the most effective strategy for reducing infarct size, reperfusion injury represents a significant limiting factor on clinical outcomes in myocardial infarction patients. Ischemic preconditioning (IPC) has been shown to inhibit reperfusion injury and represents an attractive model for studying cardioprotective signal transduction pa

The impact of diabetes, education and income on mortality and cardiovascular events in hypertensive patients : A cohort study from the Swedish Primary Care Cardiovascular Database (SPCCD)

Objective In this study we aimed to estimate the effect of diabetes, educational level and income on the risk of mortality and cardiovascular events in primary care patients with hypertension. Methods We followed 62,557 individuals with hypertension diagnosed 2001-2008, in the Swedish Primary Care Cardiovascular Database. Study outcomes were death, myocardial infarction, and ischemic stroke, asses

Cultural and Linguistic Practice with Children with Developmental Language Disorder : Findings from an International Practitioner Survey

Background: The cultural and language diversity across many European countries presents a range of challenges and opportunities for speech and language therapists and other practitioners working with children with developmental language disorders (DLD) and their families. Objective: The aim of this study was to explore practitioners' perceptions of cultural and linguistic differences in response t

The meaning of surviving three years after a heart transplant—a transition from uncertainty to acceptance through adaptation

The rationale was to longitudinally follow-up interviews performed with heart recipients at their one-year examination in order to deepen the understanding of the meaning of surviving a heart transplant. The aim was to explore the meaning of surviving three years after a heart transplant compared to one year and to identify what constitutes the change process. A phenomenological–hermeneutic method

Health locus of control and mortality : a population-based prospective cohort study

Objectives: The objective of the study was to estimate associations between health locus of control (HLC) and mortality. Study design & methods: The public health survey in Scania 2008 was linked to the Swedish cause of death register. In this study of 10,757 men and 12,322 women aged 18–80 years, 421 men and 235 women died during the 5.3-year follow-up. Survival analyses were conducted. Resul

Processing distribution and architecture tradeoff for large intelligent surface implementation

The Large Intelligent Surface (LIS) concept has emerged recently as a new paradigm for wireless communication, remote sensing and positioning. It consists of a continuous radiating surface placed relatively close to the users, which is able to communicate with users by independent transmission and reception (as a Base Station). Despite of its potential, there are a lot of challenges from an implem

Underlying event properties in pp collisions at √s = 13 TeV

This article reports measurements characterizing the Underlying Event (UE) associated with hard scatterings at midrapidity (|η| < 0.8) in pp collisions at s = 13 TeV. The hard scatterings are identified by the leading particle, the charged particle with the highest transverse momentum (pTleading) in the event. Charged-particle number-densities and summed transverse-momentum densities are measured

Resonant inelastic x-ray scattering on CO2 : Parity conservation in inversion-symmetric polyatomics

Resonant inelastic x-ray scattering (RIXS) spectra excited at the oxygen K edge of CO2 are presented and discussed. Although excitation from a gerade initial state to the intermediate 1s-1π∗ state breaks the inversion symmetry due to strong vibronic coupling, RIXS excited at the corresponding resonance exclusively populates gerade vibrations in the gerade electronic ground state. This observation

A focus group interview study of the experience of stress amongst school-aged children in Sweden

The study explored experiences of stress in children aged 10–12. An inductive qualitative design was used. Ten focus group interviews were conducted with Swedish schoolchildren (n = 42) aged 10–12. The interviews were audio-recorded, transcribed verbatim, and analyzed using qualitative content analysis. The study identified one theme—“Body and mind react”—and three subthemes: (1) Friendships matte

Synthesis and characterisation of isothiocyanate functionalised silicon nanoparticles and their uptake in cultured colonic cells

The functionalisation of silicon nanoparticles with a terminal thiocyanate group, producing isothiocyanate-capped silicon nanoparticles (ITC-capped SiNPs) has been successfully attained. The procedure for the synthesis is a two-step process that occurs via thermally induced hydrosilylation of hydrogen terminated silicon nanoparticles (H-SiNPs) and further reaction with potassium thiocyanate (KSCN)

Electroacupuncture mimics exercise-induced changes in skeletal muscle gene expression in women with polycystic ovary syndrome

Context: Autonomic nervous system activation mediates the increase in whole-body glucoseuptake in response to electroacupuncture but the mechanisms are largely unknown.Objective: To identify the molecular mechanisms underlying electroacupuncture-inducedglucose uptake in skeletal muscle in insulin-resistant overweight/obese women with andwithout polycystic ovary syndrome (PCOS).Design/Participants:

Cognitive functioning in posttraumatic stress disorder before and after cognitive-behavioral therapy

Although substantial evidence suggests altered executive functioning and autobiographical memory in posttraumatic stress disorder (PTSD), the clinical significance of these findings remains unclear. Here, we investigated the effects of cognitive-behavioral therapy (CBT) on different aspects of cognitive functioning (working memory, interference susceptibility, conflict adaptation, autobiographical

Subspecialty training in Europe : A report by the European Network of Young Gynaecological Oncologists

Background: ESGO (European Society of Gynaecological Oncology) and partners are continually improving the developmental opportunities for gynaecological oncology fellows. The objectives of this survey were to evaluate the progress in the infrastructure of the training systems in Europe over the past decade. We also evaluated training and assessment techniques, the perceived relevance of ENYGO (Eur

Effect of medical treatment in patients with systemic right ventricle

Objective: Congenitally corrected and surgical atrial redirected transposition of the great arteries (TGA) represents states where the morphological right ventricle serves as a systemic ventricle (S-RV). The S-RV is prone to failure, but data on medical treatment on this problem is limited. The purpose of this study was to evaluate the survival in adults with S-RV, with or without heart failure tr

Genetic Predisposition to Coronary Artery Disease in Type 2 Diabetes Mellitus

Background: Coronary artery disease (CAD) is accelerated in subjects with type 2 diabetes mellitus (T2D). Methods: To test whether this reflects differential genetic influences on CAD risk in subjects with T2D, we performed a systematic assessment of genetic overlap between CAD and T2D in 66 643 subjects (27 708 with CAD and 24 259 with T2D). Variants showing apparent association with CAD in strat

Predictability of food supply modulates nocturnal hypothermia in a small passerine : Food supply and nocturnal hypothermia

The combination of short days and long cold winter nights, in temperate regions, presents a major challenge for small diurnal birds. Small birds regularly employ heterothermy and enter rest-phase hypothermia during winter nights to conserve energy. However, we know little about how environmental conditions, such as food availability, shape these strategies. We experimentally manipulated food avail

Colonial and indigenous institutions in the fiscal development of French indochina

Official revenue collections in French Indochina were low compared with most other colonies in East and Southeast Asia. This fact stands in contrast to a large body of literature that claims French tax demands were a crushing burden on many indigenous people. French Indochina is often put forward as an example of one of the most extractive colonial states in Asia. This chapter reconciles these see