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COPD exacerbations: the importance of a standard definition

Efforts to assess the efficacy of new therapies in the treatment of acute exacerbations of chronic obstructive pulmonary disease (COPD) have been hampered by the lack of a widely agreed and consistently used definition. A variety of definitions have been used in clinical studies, based on changes in patient symptoms or the requirement for antibiotic therapy, oral steroids or hospitalisation. To da

Boris Lurie and NO!art

Article about the Latvian-American artist Boris Lurie, the art movement NO!art, founded by Lurie, Sam Goodman and Stanley Fischer in 1959 in New York, and the reception history of Lurie and NO!art from the 1960s until today. Accompanied by an extensive interview with Boris Lurie.

Formation of amyloid-like fibrils upon limited proteolysis of bovine alpha-lactalbumin

Bovine alpha-lactalbumin (alpha-LA) (10 g L-1) was incubated with a protease from Bacillus licheniformis at pH 7.5 and 50 degreesC. The reaction was biphasic consisting of an initial hydrolysis of intact alpha-LA and formation of dimers from large hydrolysis products within 60 min followed by aggregation of dimers into aggregates of 500 kDa. The aggregates consisted primarily of fibrillar strands

Measuring moisture gradients in cellulose fibre networks: An application of the magnetic resonance imaging method

A magnetic resonance imaging method was employed to measure moisture distributions in pulp samples. A calibration experiment shows that, in the range of moisture contents up to 1.4 g water/g dry substance, the MRI signal is linearly proportional to the mass of moisture of the pulp sample. The in-situ drying of a pulp sheet approximately 4 mm thick was them studied. The resolution in the thickness

Measurement of anti-deuteron photoproduction and a search for heavy stable charged particles at HERA

The cross section for anti-deuteron photoproduction is measured at HERA at a mean centre-of-mass energy of W-gammap=200 GeV in the range 0.2 < p(T)/M < 0.7 and y < 0.4, where M, p(T) and y are the mass, transverse momentum and rapidity of the anti-deuteron in the HERA laboratory frame, respectively. The numbers of anti-deuterons per event are found to be similar in photoproduction to those in cent

Atomic and electronic structure of the Yb/Ge(111)-(3x2) surface studied by high-resolution photoelectron spectroscopy

Using high-resolution synchrotron-radiation photoelectron spectroscopy and low-energy electron diffraction, we have studied the electronic and structural properties of the Yb-induced Ge(111)-(3x2) reconstruction with a 1/6 monolayer coverage. We found these properties to be similar in many respects to those of the metal-induced Si(111) and Ge(111) reconstructions described previously in terms of t

Fusion of RDC1 with HMGA2 in lipomas as the result of chromosome aberrations involving 2q35-37 and 12q13-15.

Rearrangements of chromosome bands 12q13-15 are frequent in various benign mesenchymal and epithelial tumors, and the gene HMGA2 seems to be the most common target within this chromosome region. In the majority of cases, the rearrangements result in a fusion of the first three exons of HMGA2 with different translocation partners. Despite the large number of HMGA2 mutations that have been reported,

Siberian wetlands: Where a sink is a source

[1] A greenhouse gas inventory can for some ecosystems be based solely on the net CO2 exchange with the atmosphere and the export of dissolved organic carbon. In contrast, the global warming effect may be more complex in ecosystems where other greenhouse gases such as CH4 or N2O have significant exchanges with the atmosphere. Through micrometeorological landscape- scale measurements from the large

Postantibiotic and sub-MIC effects of benzylpenicillin against Streptococcus pneumoniae with different susceptibilities for penicillin

Background: The purpose of the study was to examine whether penicillin-susceptible and nonsusceptible strains of Streptococcus pneumoniae exhibited different pharmacodynamic responses to benzylpenicillin. Methods: The postantibiotic effects (PAEs) and the postantibiotic sub-MIC effects (PA SMEs) were investigated by optical density against strains of S. pneumoniae with different susceptibilities t

Differences in mechanical properties of the common carotid artery and abdominal aorta in healthy males

PURPOSE: Vascular disease is differentiated throughout the vascular regions, with central arteries more prone to dilation and with peripheral arteries more prone to occlusive disease. In this study we investigated the diameter and compliance in the common carotid artery and abdominal aorta in healthy males at varying ages to assess potential differences in the aging process. METHODS: An ultrasound

Effects of dehydroepiandrosterone supplement on health-related quality of life in glucocorticoid treated female patients with systemic lupus erythematosus

The objective of this study was to evaluate the efficacy of low dose dehydroepiandrosterone (DHEA) on health-related quality of life (HRQOL) in glucocorticoid treated female patients with systemic lupus erythematosus (SLE). Forty one women (>= 5 mg prednisolone/day) were included in a double-blind, randomized, placebo-controlled study for 6 months where DHEA was given at 30 mg/20 mg (= 46 years) d

Degradation of toxaphene by Bjerkandera sp. strain BOL13 using waste biomass as a cosubstrate

The white-rot fungus Bjerkandera sp. strain BOL13 was capable of degrading toxaphene when supplied with wood chips, wheat husk or cane molasses as cosubstrates in batch culture experiments. Approximately 85% of toxaphene was removed when wheat husk was the main substrate. The production of lignin peroxidase was only stimulated when wheat husk was present in the liquid medium. Although xylanase was

The Swedish Council on Technology Assessment in Health Care (SBU) systematic overview of radiotherapy for cancer including a prospective survey of radiotherapy practice in Sweden 2001 - Summary and conclusions

A systematic assessment of radiotherapy for cancer was conducted by The Swedish Council on Technology Assessment in Health Care (SBU) and published in 1996. The assessment reviewed the scientific literature up to 1993 on the use of radiotherapy in the treatment of solid tumours. and estimated the costs associated with radiotherapy It also described the current practise of radiotherapy in Sweden 19