Background & Aims: Mutations in the HFE gene can lead to hereditary haemochromatosis (HH) and have been suggested to increase the risk of extra-hepatic diseases, especially breast and colorectal cancer. Here we investigated long-term outcomes of Swedish patients with HFE mutations. Methods: We identified 3645 patients with a homozygous p.C282Y (62%) or a compound heterozygous p.C282Y/p.H63D (3

The development of tau-PET allows paired helical filament tau pathology to be visualized in vivo. Increased knowledge about conditions affecting the rate of tau accumulation could guide the development of therapies halting the progression of Alzheimer's disease. However, the factors modifying the rate of tau accumulation over time in Alzheimer's disease are still largely unknown. Large-scale longi

Neurofilament light (NfL) is a marker of neuroaxonal injury, a prominent feature of Alzheimer's disease. It remains uncertain, however, how it relates to amyloid and tau pathology or neurodegeneration across the Alzheimer's disease continuum. The aim of this study was to investigate how plasma NfL relates to amyloid and tau PET and MRI measures of brain atrophy in participants with and without cog

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Responding to today's often transboundary emergencies, frequently characterized by unclear root causes and indistinct responsibilities as well as multiple actors, will require that responding actors come together to meet societal needs and solve problems arising in relation to those needs. In collective problem solving, representing the problem is crucial, especially in emergency situations, where

Vi lever i en apokalyptisk tid. Apokalyptisk argumentation till stor del outforskad. Artikeln presenterar en analysmodell i tre steg: upplevd ondska, tidens tecken och tillförlitlig auktoritet, inspirerad av Stephen O'Leary. Artikeln innehåller två analysexempel: USA:s förre president Donald Trump och den Islamiska staten. Båda bygger sin argumentation på en apokalyptisk världsbild.Our time is an apocalyptic time, but the argumentation in this apocalyptic time has hardly been studied by scholars of argumentation. This article shows how both Donald Trump and the jihadist warriors of ISIS appeal to an apocalyptic worldview in their argumentation. The three topos of evil, time and authority from Stephen O’Leary’s Arguing the Apocalypse are used in the analysis. Both Trump suppo

ABSTRACT: Neuroinflammation is implicated in the development and maintenance of persistent pain states, but there are limited data linking cerebrospinal fluid (CSF) inflammatory mediators with neurophysiological pain processes in humans. In a prospective observational study, CSF inflammatory mediators were compared between patients with osteoarthritis (OA) who were undergoing total hip arthroplast

Background: Finn Chambers AQUA (FCA) is a development of the Finn Chambers (FC) test system in which the test chambers are mounted on a moisture-resistant adhesive patch. FCA has pre-fixed filter papers. Because the use of FCA does not require any extra taping or use of separate filter papers, a change from FC to FCA chambers may be beneficial for both patients and patch-test technicians. Objectiv

The glabrous skin around the nostrils in mammals is called a rhinarium or planum nasale. Rhinarium skin has multiple epidermal domes that are generally assumed to form a tactile surface. The rhinarium is innervated by a branch of the trigeminal nerve which is associated with stimuli such as touch, chemical irritants and temperature. In this study, our aim was to correlate variation in rhinarium sk

Aims and objectives: To describe nurses' experiences of a child-centred family guided intervention of obesity tested within the child health services targeting children identified with overweight and their caregivers. Background: Interventions aiming to support families towards a healthier lifestyle can lead to decreased risk of overweight evolving into obesity in a child. At the same time, nurses

Linear Parameter Varying (LPV) models can be used to describe the vehicular lateral dynamic behavior of self-driving cars. They are particularly suitable for model-based control schemes such as model predictive control (MPC) applied to real-time trajectory tracking control, since they provide a proper trade-off between accuracy in different scenarios and reduced computation cost compared to nonlin

The use of concepts is a vital part of the research process. Many researchers overexploit popular concepts by adding more and more vague and poorly defined meanings to them, thereby making their boundaries unclear and the concepts increasingly unwieldy. We will refer to these types of concepts as hembigs – an acronym for hegemonic, ambiguous, big concepts. The article demonstrates the problem in t

Background and purpose: Various blood biomarkers reflecting brain amyloid-β (Aβ) load have recently been proposed with promising results. However, to date, no comparative study amongst blood biomarkers has been reported. Our objective was to examine the diagnostic performance and cost effectiveness of three blood biomarkers on the same cohort. Methods: Using the same cohort (n = 68), the performan