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Use of calcium channel blockers as antihypertensives in relation to mortality and cancer incidence: a population-based observational study

Abstract Purpose Treatment with blood pressure lowering drugs may reduce morbidity and mortality. However, the efficacy and effectiveness may differ between antihypertensive agents. The current investigation aimed to compare mortality and cancer incidence in hypertensive patients treated with calcium channel blockers (CCB) or with other antihypertensive drugs (AHD). Methods All patients in two o

Analysis of an extended ionization equilibrium in the post-flame gases for spark ignited combustion

Constant volume combustion is studied, using a zero-dimensional model, which is a wide-ranging chemical kinetic simulation that allows a closed system of gases to be described on the basis of a set of initial conditions. The model provides an engine- or reactor-like environment in which the engine simulations allow for a variable system volume and heat transfer both to and from the system. The com

Size Characterisation of Water-Soluble Polymers Using Asymmetrical Flow Field-Flow Fractionation

Popular Abstract in Swedish Denna avhandling behandlar storlekskarakterisering av stora molekyler (polymerer) med en ny teknik, nämligen flödesfältflödesfraktionering (flödesFFF). Det aktuella storleksområdet som studerats i avhandlingen är intervallet mellan några få nanometer(nm) upp till en halv mikrometer (um). Storleksbestämningen med flödesFFF baseras på en separation av material med olika dSize, as expressed by molar mass, radius of gyration or hydrodynamic radius, for example, is a fundamental parameter of polymers in solution. Thus, there is a strong need for the characterisation of both the size and shape of polymers, particularly of those utilised in various industrial applications. In this thesis, a relatively novel technique, asymmetrical flow field-flow fractionation (flow FF

Real time viterbi optimization of hidden Markov Models for multi target tracking

In this paper the problem of tracking multiple objects in image sequences is studied. A Hidden Markov Model describing the movements of multiple objects is presented. Previously similar models have been used, but in real time system the standard dynamic programming Viterbi algorithm is typically not used to find the global optimum state sequence, as it requires that all past and future observation

Single-Photon Events in the DELPHI Experiment

A series of studies pertaining to the STIC calorimeter at the DELPHI experiment at LEP is presented, and a new generation of fast wire scanners for emittance measurements at PS is described. The STIC studies are centered around a single-photon analysis, in which the reaction e+ e- -> gamma + invisible particles was studied at center-of-mass energies of 161, 172 and 183 GeV. The cross section thus

Multimodal design : Media structures, media principles and users’ meaning-making in printed and digital media

Modern media messages are visually fragmented since they are built up of various visual elements and units (Holsanova & Nord, 2010). This tendency has also been described as atomization of news texts (Knox, 2007) or as modularization of the text design (Bucher, 2000). Media messages are also multimodal in the sense that they contain delimited parts of text (articles, headlines, briefs, lists o

Gender, Technology and Knowledge

During the last 15 years questions concerning gender, technology and knowledge, have become increasingly recognized as central to the field of the sociology of technology. Nonetheless, critical questions remain unanswered. These issues are addressed here through investigations of the relationship between gender, work, knowledge and technology. This thesis is composed of an introduction and four in

Spontaneous Movements during Sleep Guide Spinal Self-organization: Formation and Expression of a Memory Trace

Popular Abstract in Swedish Till ryggmärgen kommer känselinformation om vad som händer med kroppen. Denna information använder vi sedan för att kunna korrigera våra rörelser. Många av dessa korrektioner utförs mer eller mindre självständigt av nervkretsar belägna i ryggmärgen. Att snabbt omvandla dessa känselsignaler till muskelaktivitet är oerhört komplicerat och beräkningskrävande eftersom kroppDuring development, information about the three-dimensional shape and mechanical properties of the body is laid down in the synaptic connectivity of sensorimotor systems through adaptive mechanisms. In spinal reflex systems, this enables the fast transformation of complex sensory information into adequate correction of movements. In this thesis, it is shown, in a computer simulation, that an unsup

Three-terminal ballistic junctions: New building blocks for functional devices in nanoelectronics

Present digital logic gates are primarily built from field effect transistors (FETs) such as complementary metal oxide semiconductors with the gate length in the deep sub-μm regime. As device feature sizes approach the nanometer regime, fundamental physical constraints and increasingly prohibitive economic costs will make further miniaturization in electronic circuits difficult, and this has motiv

Requirements prioritisation: an experiment on exhaustive pair-wise comparisons versus planning game partitioning

The process of selecting the right set of requirements for a product release is highly dependent on how well we succeed in prioritising the requirements candidates. There are different techniques available for requirements prioritisation, some more elaborate than others. In order to compare different techniques, a controlled experiment was conducted with the objective of understanding differences

Pharmacokinetics of the enantiomers of thalidomide

Popular Abstract in Swedish Det finns ett ökat intresse för behandling med talidomid. Därför var målsättningen med detta avhandlingsarbete att åstadkomma en mer ändamålsenlig användning. Några kemiska och farmakologiska aspekter med speciell inriktning på omsättningen av talidomid i människokroppen studerades. Historien om talidomid (Neurosedyn; varumärke i Sverige) är ett tragiskt kapitel i läkeThalidomide has a chiral center and the racemate of (+)-(R) and (-)-(S)-thalidomide was introduced as a hypnotic/sedative drug in 1957. In 1961 it was withdrawn due to teratogenicity and neuropathy. There is a growing interest in thalidomide treatment of immunomodulatory diseases. Given this renewed interest the aim of this thesis was to achieve a more rational use of thalidomide. Therefore some c