The ultimate goal in the treatment of high-responding inhibitors in congenital haemophilia is to induce immune tolerance (IT). Since the advent of highly purified factor VIII products, especially recombinant ones, the issue has been raised of whether the type of product has an impact on treatment success. It is clear that IT induction is possible to achieve with both recombinant products and human

We demonstrate that the a. chain of human C4b binding protein (C4BP) binds directly to CD40 on human B cells at a site that differs from that used by CD40 ligand. C4BP induces proliferation, upregulation of CD54 and CD86 expression, and IL4-dependent IgE isotype switching in normal B cells but not in B cells from patients with CD40 or IKKgamma/NEMO deficiencies. Furthermore, C4BP colocalized with

Precipitation and runoff data from several controlled experiments (with dry and wet initial conditions) on a Sedum album green-roof have been analysed by means of linear programming in order to estimate a unit hydrograph (UH). The obtained UH was able to accurately predict peak flows and runoff volumes for any rain input. Results from the experiments indicated that roof slope had no effect on the

This article reflects on theory in social work. With a starting point in the contemporary discussion of evidence-based social work, we raise questions about the role of theory. To understand empirical data, we need theory. The arena of social work is an open field for many academic disciplines, and theories used for understanding social work are mostly imported from general social science. Theory

STUDY OBJECTIVE: To assess whether the increased incidence of myocardial infarction and death associated with smoking, hypertension, hyperlipidaemia and diabetes varies significantly between groups defined in terms of occupation, education and marital status. SETTING: Malmo, Sweden. PARTICIPANTS: 9351 women, aged 28-55, with a mean follow up of 10.7 years. MAIN RESULTS: Smoking, hypertension (> or

The anisotropy parameter (v(2)), the second harmonic of the azimuthal particle distribution, has been measured with the PHENIX detector in Au+Au collisions at roots(NN)=200 GeV for identified and inclusive charged particle production at central rapidities (eta2 GeV/c, in marked contrast to the predictions of a hydrodynamical model. A quark-coalescence model is also investigated.

Background: It is possible that efforts in ECG review by both young experienced clinicians are currently discouraged-and risk to be completely dismissed-by the conventional (ie, disorderly) display of the frontal plane leads, with lead aVR at -150degrees. Methods: We reviewed studies on the usefulness of leads aVR and -aVR as well as on the history of the frontal leads in electrocardiography. Resu

This article investigates how managers position themselves and their work in terms of leadership in a large knowledge-intensive company. The significance of contemporary discourse on leadership, practical aspects of managerial work, and ambiguity as a central dimension of organization and leadership (particularly in knowledge-intensive settings) are highlighted. We examine the presumed leadership

Background: The relationship between experience of fatigue and emotional and symptom distress in chronic heart failure (CHF) needs to be thoroughly explored, because fatigue has major impact on daily activities in life. Aims: The purpose was to examine the association between fatigue, as a multidimensional experience and anxiety, depression and symptom distress, and to explore the relationships be

We compare Forward Error Correction (FEC) and frame AC-Cumulation (ACC) to see which of the two schemes most effectively reduce frame loss rate for an aggregate of VoIP flows, sharing a network bottleneck. We model this bottleneck by a M/M/1/K queue and we analytically show that given certain assumptions, FEC is the best choice for low initial load at the bottleneck. Then, as the initial load incr

This paper describes the use of supervised methods for the classification of vegetation. The difference between supervised classification and clustering is outlined, with reference to their current use in vegetation science. In the paper we describe the classification of Danish grasslands according to the Habitats Directive of the European Union, and demonstrate how a supervised classification can

The cell-cell adhesion protein junctional adhesion molecule-A (JAM-A) influences; epithelial cell morphology and migration. As migration is required for tumor cell invasion and metastasis, we sought to elucidate the role of JAM-A in invasive breast cancer. A breast cancer tissue microarray was analyzed for JAM-A protein expression, in parallel with analysis of JAM-A gene expression data from a bre

The potential of a nucleic acid-based optical bioprobe for environmental measurements and drug monitoring is described. The sensor employs the long-wavelength intercalating fluorophore TO-PRO-3 (TP3). Compounds that interact with the TP3-DNA complex are indirectly detected by a decrease in the fluorescence intensity. We found that the configuration and length of the DNA dramatically affected the i

Organ-specific or endocrine autoimmune diseases are complex, polygenic afflictions the penetrance of which is heavily dependent on various environmental influences. Important target tissues are the thyroid, the islets of Langerhans, gastric parietal cells and steroid-producing cells in the adrenal and ovary. The etiology of these diseases remains to be clarified. The pathogenesis is strongly assoc

Highly efficient washing and extraction of microbeads to decomplex analytes ranging from small peptides to large viruses was realised in a microscaled continuous flow format. The bead washing principle reported herein is based on acoustophoresis, i.e. the primary acoustic radiation force in an ultrasonic standing wave and laminar flow properties are utilised to translate bioanalytes trapped on fun

A simple turbidimetric method was developed to measure the bulk concentration of drug in nanosuspensions. The bulk concentrations measured were in the range from 1 mu M to 1 mM. The accuracy of the method was checked by determination of the bulk concentration of crystalline nanosuspensions, i.e., the crystalline solubility, which compared favorably to solubilities measured by a conventional method

Some problems in mechanics, e.g. in bearing simulation, contain subsystems that are conservative as well as weakly dissipative subsystems. Our experience is that geometric integration methods are often superior for such systems, as long as the dissipation is weak. Here we develop adaptive methods for dissipative perturbations of Hamiltonian systems. The methods are "geometric" in the sense that th