Filetype
Background: Psoriasis is one of the most frequent skin diseases world-wide. The disease impacts enormously on affected patients and poses a huge financial burden on health care providers. Several lines of evidence suggest that the nuclear hormone receptor peroxisome proliferator activator (PPAR) beta/delta, known to regulate epithelial differentiation and wound healing, contributes to psoriasis pa
Popular Abstract in Swedish Proteiner är nödvändiga beståndsdelar i en levande cell. Dels bygger de upp viktiga strukturer och dels katalyserar de kemiska reaktioner. Proteiner kodas av gener. Varje protein motsvaras av en gen. Vägen från gen till protein är densamma i alla organismer på jorden. Först transkriberas en gen till en molekyl kallad mRNA (budbärar-RNA, eng. messenger RNA). Detta mRNA aDegradation of mRNA is a controlled process which is as important for gene regulation as the synthesis of mRNA. This thesis focuses on mechanisms of mRNA stability and degradation in Bacillus subtilis, the model of Gram-positive bacteria. The aprE mRNA, encoding an exported protease named subtilisin, is extremely stable with a half-life of more than 25 minutes. Average mRNA half-lives in B. subtil
Popular Abstract in Swedish Deponeringsavgifterna för slam utgör en betydande och stadigt stigande andel av driftkostnaderna för de kommunala reningsverken runtom i landet, inom EU och i resten av världen. Kostnaderna uppstår i samband med att slammet komposteras, körs till deponi eller till förbränning. Dessutom har det under de gångna årtiondena skett en drastisk omvärdering av reningsverksslam The reduction of sludge volumes for disposal is a topic of high interest for wastewater treatment plants (WWTP) all over the world. Steadily increasing volumes for disposal create an economic, environmental, legislative and technological challenge. Researchers and process developers try to minimise the sludge during its genesis or in the downstream treatment. Due to rising costs and scarcity of fo
One of the goals pursued in the present research was to understand the nuclear phenomena (such as rotational bands, their backbending and termination, deformation, pairing correlations, etc.) using different views provided by different nuclear models. The employed models complement each other: spherical shell model provided the laboratory frame description, the intrinsic frame description was prov
Popular Abstract in Swedish Populärvetenskaplig sammanfattning Vår arvsmassa består av tre olika typer av DNA; kodande, reglerande och ofunktionellt DNA. Det kodande DNA:t används som ritning för hur våra proteiner ska sättas ihop. Proteinerna är de stenar som bygger upp våra celler och ger dem dess specifika funktion, en hudcell är t ex uppbyggd av andra proteiner än en muskelcell. Det är viktigtThe neutrophil store its effector proteins in several distinct types of cytoplasmic granules, developed sequentially during cell maturation. The different subtypes of granules have unique protein content and functional characteristics. The formation of each granule subtype coincides with the biosynthesis of its content. Granule proteins synthesised during the formation of a granule subtype are thu
Against the deeply ingrained belief that technology is instrumental and neutral, this thesis argues that our relation to technology is inextricably bound up with fantasies. But what is the nature of these fantasies and where do we find them? Are they strictly reserved to the domain of Science Fiction, or can we also find them in more mundane contexts, like the business organization? These are som
Current-mode control can be used to control switched DC-DC power converters. This paper compares two continuous-time models for current-mode control that are made to be accurate up to half the switching frequency. The two models are the ones presented by Ridley and Tan. The closed loop frequency responses predicted by these two models are compared with results obtained from simulations of a buck c
Riter och ritual är mångsidiga fenomen vilket gör att studiet av formaliserade handlingar återfinns inom flera ämnesdiscipliner. I Den rituella människan – flervetenskapliga perspektiv visar forskare inom arkeologi, etnologi, psykologi, teatervetenskap, religionshistoria och teologi hur de har funderat över den rituella praktiken. Varför använder människan sig av riter, hur kan rit och ritual stud
Web sites are exposed to high rates of incoming requests. The servers may become overloaded during temporary traffic peaks when more requests arrive than the server is designed for. An admission control mechanism rejects some requests whenever the arriving traffic is too high and thereby maintains an acceptable load in the system. This paper presents how admission control mechanisms can be designe
Governmental organisations are becoming more critically dependant on IT systems such as communication systems or patient data systems, both for their everyday tasks and their role in crisis relief activities. Therefore it is important for the organisation to analyse the reliability of these systems as part of the organisation’s risk and vulnerability analysis process. This paper presents a practic
