The ability to determine the myelin water fraction (MWF) in vivo is essential to assessments of neurodevelopmental myelination and myelin damage in neurodegenerative diseases. The analysis of multi-exponential T2 decay data relies on the non-negative-least-squares (NNLS) fitting, which may be sensitive to the chosen fitting parameters. We performed simulations to explore the outcomes of NNLS under

BackgroundMortality among children under five remains a significant health challenge across sub-Saharan Africa. HIV/AIDS is one of the leading contributors to the relatively slow decline in under-five mortality in this region. In Tanzania, HIV prevalence among under-five children is high and 90% of all infections are due to mother-to-child transmission.ObjectivesThe study aimed to examine the asso

We discuss the properties of Hα emission stars across the sample of 22035 spectra from the Gaia-ESO Survey internal data release, observed with the GIRAFFE instrument and largely belonging to stars in young open clusters. Automated fits using two independent Gaussian profiles and a third component that accounts for the nebular emission allow us to discern distinct morphological types of Hα line pr

BACKGROUND: Post mortem brain tissue data and animal modeling work indicate cholinergic disruptions in autism. Moreover, the cholinergic system plays a key role in the early neurodevelopmental processes believed to be derailed early in life in individuals with the disorder. Yet, there is no data from human infants supporting a developmentally important role of this neurotransmitter system. Because

Wind is a complex phenomenon and a critical fac-tor in assessing climatic conditions and pedestrian comfortwithin cities. To obtain spatial information on near-groundwind speed, 3D computational fluid dynamics (CFD) model-ling is often used. This is a computationally intensive methodwhich requires extensive computer resources and is time con-suming. By using a simpler 2D method, larger areas can b

During bacterial infections at mucosal sites, neutrophils migrate to the mucosa and cross the epithelial barrier. We have examined neutrophil migration across Escherichia coli-stimulated uroepithelial cell layers in an attempt to more fully understand this process. Stimulation of uroepithelial cells with E. coli or interleukin-1α (IL-1α) induced transepithelial neutrophil migration in a time- and

Concentrated solutions of monoclonal antibodies have attracted considerable attention due to their importance in pharmaceutical formulations; yet, their tendency to aggregate and the resulting high viscosity pose considerable problems. Here we tackle this problem by a soft condensed matter physics approach, which combines a variety of experimental measurements with a patchy colloid model, amenable

Visual field testing which the Computer fully automatic computerized perimeter (Heijl & Krakau 1975) employing a supra-liminal screening test procedure was used in a material of 1013 eyes with ocular hypertension in which earlier routine perimetry (kinetic and static) on the Goldmann perimeter had yielded a normal result. The automatic screening was repeated if positive, and manual control per

Naturvårdsverket har i regleringsbrevet för år 2009 fått i uppdrag av regeringen att redovisa vilka uppgifter som verket bedömer behövs i miljöriskbedömning-en av genmodifierade (GM) grödor för att kunna ta naturvårdshänsyn till lång-siktiga effekter och effekter på icke-målorganismer. Denna rapport utgör redo-visningen av uppdraget.Utveckling och användning av genetiskt modifierade organismer (GM

Naturvårdsverket har i regleringsbrevet för år 2009 fått i uppdrag av regeringen att redovisa vilka element som verket bedömer bör ingå i övervakningen av GMO som introduceras i miljön för försök eller i kommersiell odling. I samråd med Miljödepartementet har uppdraget avgränsats till att inte inkludera försök, utan enbart beröra kommersiell odling. Denna rapport utgör redovisningen av uppdraget.I