Deficiencies of the early complement components of the classical pathway (CP) are well-documented in association with systemic lupus erythematosus (SLE) or SLE-like syndromes and severe pyogenic infections. Among these, complete C1s deficiency has been reported in nine cases so far. Here, we describe a 34-year-old male patient who presented with severe, recurrent infections since childhood, includ

Snapshot spectral imaging enables the acquisition of hyperspectral images (HSI) employing specialized optical systems, such as the coded aperture snapshot spectral imager (CASSI). Specifically, the CASSI system performs spatiospectral codification of light obtaining two-dimensional projected measurements, and these measurements are then processed by computational algorithms to obtain the desired s

Smallholder farmer-based rural social movements have been heralded as a promising source of political power with the potential to effectively promote sustainable trajectories of agricultural development in Sub-Saharan Africa and beyond. However, the very early stages of rural social movement building remain understudied, including under what conditions such nascent efforts are likely to lead to ef

Most children grow up in urbanised settings with a low possibility to experience biodiversity and nature. However, experiencing nature and other species increases children’s wellbeing, health, learning abilities and their understanding of nature values. Play biotopes is one solution for supporting a co-existence between children and different species in nature-based play settings. Play biotopes ar

Intensivvårdsavdelningen (IVA) tar hand om de mest kritiskt sjuka patienterna, ofta med multiorgansvikt. Denna patientgrupp kräver kontinuerlig övervakning av vitala funktioner som blodtryck, EKG och syremättnad. Varje patient på IVA kräver dessutom upprepad provtagning, ibland så ofta som var 15:e min. Denna ständiga övervakning leder till insamling av mycket patientdata som varje läkare/sjukvård

Increasing imperviousness in urban areas, and changes in rainfall intensity and return periods because of climate change increase urban flood risk. This study utilizes the hydraulic model Mike+ to assess the multifunctional use of existing roads and parking lots, which could serve to either retain or detain stormwater and accommodate trees, plants, and vegetation as part of a low-impact developmen

Introduction: Differentiating Parkinson's disease (PD) from progressive supranuclear palsy (PSP) and multiple system atrophy (MSA) is a common clinical problem. We aimed to apply the T1-/T2-weighted ratio imaging technique, based on standard clinical MRI, to reveal differences in neurodegeneration in three large cohorts. Methods: Three cohorts, with a total of 405 participants (269 PD, 44 PSP, 38

OBJECTIVES: Head and neck cancer (HNC) is the sixth most common cancer worldwide. The condition and its treatment often lead to marked morbidities and, for some patients, premature death. Inferentially, HNC imposes a significant economic burden on society. This study aims to provide a comprehensive and detailed estimation of the cost of illness of HNC for Sweden in 2019.METHODS: This is a prevalen

Studie av den norska krigsfilmen Kampen om Narvik.

Purpose: To assess the impact of fine-needle aspiration cytology (FNAC) in the extent of surgery in patients with thyroid cancer (TC) and the associated surgical morbidity in primary and completion setting. Methods: A Swedish nationwide cohort of patients having surgery for TC (n = 2519) from the Scandinavian Quality Register for Thyroid, Parathyroid and Adrenal surgery between 2004 and 2013 was o

The Swedish electricity system is undergoing a transition unprecedented in both speed and scale, thereby exposing a number of policy-related controversies. In this study, six central themes in the on-going debates around the security of electricity supply in Sweden are identified based on a material of over 1000 news articles, published between the years 2010–2022. By applying the themes to the po

This paper presents a simple and effective control solution to regulate temperature and humidity inside a greenhouse, which are the main climatic variables affecting crop growth and health. A multivariable control strategy with inverted decoupling is proposed in two schemes. The nighttime control scheme uses heating and dehumidification, and the daytime control scheme uses natural ventilation, deh

We consider a two-dimensional point process whose points are separated into two disjoint components by a hard wall, and study the multivariate moment generating function of the corresponding disk counting statistics. We investigate the “hard edge regime” where all disk boundaries are a distance of order [Formula presented] away from the hard wall, where n is the number of points. We prove that as

The European Alps are rapidly losing glacier mass due to climatic warming and are anticipated to be largely ice-free by the year 2100. Long-term glacier monitoring in the Alps provides a record of anthropogenically-driven climate change since the Little Ice Age maximum in ~1850. Understanding these long-term glacier changes provides a basis for mitigating hazards (e.g., mass movements) associated

Optic neuritis (ON) is associated with numerous immune-mediated inflammatory diseases, but 50% patients are ultimately diagnosed with multiple sclerosis (MS). Differentiating MS-ON from non-MS-ON acutely is challenging but important; non-MS ON often requires urgent immunosuppression to preserve vision. Using data from the United Kingdom Biobank we showed that combining an MS-genetic risk score (GR

Background: Following exposure to traumatic stress, women are twice as likely as men to develop mood disorders. Yet, individual responses to such stress vary, with some people developing stress-induced psychopathologies while others exhibit resilience. The factors influencing sex-related disparities in affective disorders as well as variations in resilience remain unclear; however, emerging eviden

DNA mismatch repair (MMR) is thought to contribute to the onset and progression of Huntington disease (HD) by promoting somatic expansion of the pathogenic CAG nucleotide repeat in the huntingtin gene (HTT). Here we have studied constitutional HTT CAG repeat size in two cohorts of individuals with Lynch syndrome (LS) carrying heterozygous loss-of-function variants in the MMR genes MLH1 (n = 12/60;