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Flight activity and effort of breeding pied flycatchers in the wild, revealed with accelerometers and machine learning

Flight behaviours of birds have been extensively studied from different angles such as their kinematics, aerodynamics and, more generally, their migration patterns. Nevertheless, much is still unknown about the daily foraging flight activity and behaviour of breeding birds, and potential differences among males and females. The recent development of miniaturized accelerometers allows us a glimpse

Review article : Drought as a continuum – memory effects in interlinked hydrological, ecological, and social systems

Droughts are often long-lasting phenomena, without a distinct start or end and with impacts cascading across sectors and systems, creating long-term legacies. Nevertheless, our current perceptions and management of droughts and their impacts are often event-based, which can limit the effective assessment of drought risks and reduction of drought impacts. Here, we advocate for changing this perspec

Gene Therapy with Fidanacogene Elaparvovec in Adults with Hemophilia B.

Background Fidanacogene elaparvovec, an adeno-associated virus (AAV) gene-therapy vector for hemophilia B containing a high-activity human factor IX variant (FIX-R338L/FIX-Padua), was associated with sustained factor IX activity in a phase 1-2a study. Methods We conducted a phase 3 open-label study of fidanacogene elaparvovec at a dose of 5×1011 vector genome copies per kilogram of body weight. Me

Transfer learning reconstructs submarine topography for global mid-ocean ridges

Mid-ocean ridges are unique, tectonically active geographical units on Earth that profoundly control the ocean environment and dynamics at the global scale. However, high-resolution topographic data from mid-ocean ridges are rarely available due to the difficulty in detecting ocean floors, which further limits ocean research at the global scale. Here, we divide the global mid-ocean ridge system in

Challenges in the practical implementation of blood biomarkers for Alzheimer's disease

Blood biomarkers have emerged as accessible, cost-effective, and highly promising tools for advancing the diagnostics of Alzheimer's disease. However, transitioning from cerebrospinal fluid biomarkers to blood biomarkers—eg, to verify amyloid β pathology—requires careful consideration. This Series paper highlights the main challenges in the implementation of blood biomarkers for Alzheimer's diseas

Fluid biomarkers in the context of amyloid-targeting disease-modifying treatments in Alzheimer's disease

Clinical management and therapeutics development for Alzheimer's disease (AD) have entered a new era, with recent approvals of monoclonal antibody therapies targeting the underlying pathophysiology of the disease and modifying its trajectory. Imaging and fluid biomarkers are becoming increasingly important in the clinical development of AD therapeutics. This review focuses on the evidence of fluid

Evaluation of data quality in the Swedish National Penile Cancer Register

Objective: The National Penile Cancer Register (NPECR) in Sweden was initiated in year 2000 and currently contains more than 3,900 men diagnosed with penile cancer. The aim of this study was to evaluate data quality in the NPECR in terms of completeness, timeliness, comparability, and validity. Material and methods: Completeness was assessed by cross-linkage to the Swedish Cancer Register. Timelin

South and/or North: An Indigenous Seed Movement in South Korea and the Multiple Meanings of Food Sovereignty

South Korean cultivators share features with counterparts in both the global south and north. This combination of traits has produced a diversity of sources that underpin a food sovereignty movement. A case study of t’ojong, or native, seed activism illustrates how local systems of meaning and particular constellations of interests make food sovereignty appealing to a broad coalition of farmers, c

Diversity in IPCC author’s composition does not equate to inclusion

The IPCC holds the gold standard for climate change scientific knowledge and authority at the science–policy interface. Here we reflect on our experience of the IPCC Sixth Assessment Report and discuss how diversity in authorship and inclusion of different disciplinary backgrounds can be improved.

Transforming Personal Daily GPS Data Through Performances: Movement, Memory and Time

This thesis examines three plan b performance pieces, which are all based on a long-term practice of recording GPS data daily (15 years for me at time of writing). The works comprise different performative processes to materialise the data through public drawing, narrating and collective knotting. Each of the pieces is related to the respective central themes of movement, memory and time. Through

The Infinite Body

The Drawing of Our Lives in Berlin 2007-2022 (2022) and Narrating our Lines (2010) for the group exhibition 'The infinite body' at Ramat Gan Museum of Israeli Art, plan b are showing an installation combining two existing works - a large scale drawing and a video work.

Enhancing Autonomous Vehicles System Security : Advanced Attack Detection for Robust Safeguarding

The advances in highly automated and autonomous transportation systems over the last decade have generated great interest in topics in the safe navigation of land vehicles. With distributed control strategies employed in the majority of applications of autonomous vehicles, such as traffic and formation control, the much-required resilience takes the form of fault-tolerance with respect to informat

Hybrid Precoder Design for Angle-of-Departure Estimation with Limited-Resolution Phase Shifters

Hybrid analog-digital beamforming stands out as a key enabler for future communication systems with a massive number of antennas. In this paper, we investigate the hybrid precoder design problem for angle-of-departure (AoD) estimation, where we take into account the practical constraint on the limited resolution of phase shifters. Our goal is to design a radio-frequency (RF) precoder and a base-ba

Identifying constraints on Gen Z’s path toward ethical tourism consumption and practices

Gen Z’s interest in ethical consumption, including tourism, is growing in response to pressing global challenges. However, there is limited research on the constraints tied to the ethical travel decisions of this young cohort of travelers. This qualitative study, grounded in the theory of constraints and ethical consumerism literature, addresses this gap. The findings reveal multi-layered and inte

Prediction of adverse maternal and perinatal outcomes associated with pre-eclampsia and hypertensive disorders of pregnancy : a systematic review and meta-analysis

Background: Hypertensive disorders of pregnancy are a leading cause of maternal and perinatal morbidity and mortality. If women at high risk for developing complications could be identified early, level of care could be triaged, limited resources could be correctly allocated and targeted interventions to prevent complications could be implemented. Methods: We updated a systematic review and meta-a

MRI-Derived AD Signature of Cortical Thinning and Plasma P-Tau217 for Predicting Alzheimer Dementia Among Community-Dwelling Older Adults

Background and Objectives Structural brain MRI and blood-based phosphorylated tau (p-tau) measures are among the least invasive and least expensive Alzheimer's disease (AD) biomarkers to date. The extent to which these biomarkersmay outperformone another in predicting future Alzheimer dementia diagnosis is poorly understood, however. This study investigated 2 specific AD biomarkers, i.e., a cortic

A prebiotic oligofructose-enriched inulin preparation stimulates intestinal growth and function in suckling rats

Postnatal development of the gastrointestinal (GI) tract in mammals is influenced, to an unknown extent, by the diet and the microflora. The aim of the current study was to clarify the role of a dietary fibre on postnatal Gl development, by studying the effects of aprebiotic oligofructose-enriched inulin preparation (Synergy 1) on GI growth and function in a suckling rat modcl Between 10 and 16 da