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Bivalirudin versus heparin monotherapy in non-ST-segment elevation myocardial infarction

BACKGROUND: The optimal anti-coagulation strategy for patients with non-ST-elevation myocardial infarction treated with percutaneous coronary intervention is unclear in contemporary clinical practice of radial access and potent P2Y12-inhibitors. The aim of this study was to investigate whether bivalirudin was superior to heparin monotherapy in patients with non-ST-elevation myocardial infarction w

Hypertension, hypotension and syncope

Hypertension and hypotension are strictly related phenomena, that frequently coexist within the spectrum of cardiovascular autonomic dysfunction, especially at advanced age. Indeed, antihypertensive treatment may predispose to orthostatic and post-prandial hypotension, while intensive blood pressure lowering may be responsible for systemic hypotension. Over recent years, systemic and orthostatic h

Digital Corporate Communication and Internal Communication

Internal communication is becoming increasingly digital. This chapter deals with how digital internal communication can be understood and discusses the implications of the digitalization of internal communication for organizations and organizing. It reviews previous definitions of internal communication and digitalization and proposes a definition of digital internal communication. It reviews prev

Assessing the economic benefits of active transport policy pathways: Opportunities from a local perspective

Combined with concerns about climate change, air pollution and human health, the COVID-19 pandemic has renewed the use of and policy interest in active transport (AT) modes, namely cycling and walking. However, we note a high degree of uncertainty and lack of assessments addressing the economic benefits of AT policies; particularly when they are used as a mix of policies at the local level. This s

Clinical impact of intraprocedural stent thrombosis during percutaneous coronary intervention in patients treated with potent p2y12 inhibitors -A validate-swedeheart substudy

BACKGROUND: The clinical importance of intraprocedural stent thrombosis (IPST) during percutaneous coronary intervention in the contemporary era of potent oral P2Y12 inhibitors is not established. The aim of this study was to assess IPST and its association with clinical outcome in patients with myocardial infarction undergoing percutaneous coronary intervention with contemporary antithromboticmed

Bivalirudin Versus Heparin Monotherapy in ST-Segment-Elevation Myocardial Infarction

BACKGROUND: Bivalirudin was not superior to unfractionated heparin in patients with myocardial infarction (MI) treated with percutaneous coronary intervention and no planned use of GPI (glycoprotein IIb/IIIa inhibitors) in contemporary clinical practice of radial access and potent P2Y12-inhibitors in the VALIDATE-SWEDEHEART randomized clinical trial (Bivalirudin Versus Heparin in STEMI and NSTEMI

Interferon regulatory factor-5-dependent CD11c+ macrophages contribute to the formation of rupture-prone atherosclerotic plaques

AIMS: Inflammation is a key factor in atherosclerosis. The transcription factor interferon regulatory factor-5 (IRF5) drives macrophages towards a pro-inflammatory state. We investigated the role of IRF5 in human atherosclerosis and plaque stability.METHODS AND RESULTS: Bulk RNA sequencing from the Carotid Plaque Imaging Project biobank were used to mine associations between major macrophage assoc

Tea consumption and risk of bladder cancer in the Bladder Cancer Epidemiology and Nutritional Determinants (BLEND) Study : Pooled analysis of 12 international cohort studies

Background & aims: Tea has been shown to be associated with reduced risk of several diseases including cardiovascular diseases, stroke, metabolic syndrome, and obesity. However, the results on the relationship between tea consumption and bladder cancer are conflicting. This research aimed to assess the association between tea consumption and risk of bladder cancer using a pooled analysis of pr

Odorant receptor orthologues in conifer-feeding beetles display conserved responses to ecologically relevant odours

Insects are able to detect a plethora of olfactory cues using a divergent family of odorant receptors (ORs). Despite the divergent nature of this family, related species frequently express several evolutionarily conserved OR orthologues. In the largest order of insects, Coleoptera, it remains unknown whether OR orthologues have conserved or divergent functions in different species. Using HEK293 ce

Comparison of machine learning and process-based SWAT model in simulating streamflow in the Upper Indus Basin

This study appraised and compared the performance of process-based hydrological SWAT (soil and water assessment tool) with a machine learning-based multi-layer perceptron (MLP) models for simulating streamflow in the Upper Indus Basin. The study period ranges from 1998 to 2013, where SWAT and MLP models were calibrated/trained and validated/tested for multiple sites during 1998–2005 and 2006–2013,

Embedded 3D Printing in Self-Healing Annealable Composites for Precise Patterning of Functionally Mature Human Neural Constructs

Human in vitro models of neural tissue with tunable microenvironment and defined spatial arrangement are needed to facilitate studies of brain development and disease. Towards this end, embedded printing inside granular gels holds great promise as it allows precise patterning of extremely soft tissue constructs. However, granular printing support formulations are restricted to only a handful of ma

Prediction of Sound Insulation Using Artificial Neural Networks—Part I : LightweightWooden Floor Structures

The artificial neural networks approach is applied to estimate the acoustic performance for airborne and impact sound insulation curves of different lightweight wooden floors. The prediction model is developed based on 252 standardized laboratory measurement curves in one-third octave bands (50-5000 Hz). Physical and geometric characteristics of each floor structure (materials, thickness, density,

Antenatal intravenous immunoglobulins in pregnancies at risk of fetal and neonatal alloimmune thrombocytopenia : comparison of neonatal outcome in treated and nontreated pregnancies

Background: Maternal alloantibodies to human platelet antigen-1a can cause severe intracranial hemorrhage in a fetus or newborn. Although never evaluated in placebo-controlled clinical trials, most Western countries use off-label weekly administration of high-dosage intravenous immunoglobulin in all pregnant women with an obstetrical history of fetal and neonatal alloimmune thrombocytopenia. In No

Exploring occupations and well-being before and during the COVID-19 pandemic in adults with and without inflammatory arthritis

To decrease the spread of the COVID-19 virus, public health officials in British Columbia, Canada ordered large-scale physical distancing requirements, leading to school and business closures, banning of large gatherings, and travel restrictions. These requirements shifted people’s occupational repertoires, with vulnerable populations (e.g., those with chronic health conditions) possibly being dif

SRKCD : A stabilized Runge–Kutta method for stochastic optimization

We introduce a family of stochastic optimization methods based on the Runge–Kutta–Chebyshev (RKC) schemes. The RKC methods are explicit methods originally designed for solving stiff ordinary differential equations by ensuring that their stability regions are of maximal size. In the optimization context, this allows for larger step sizes (learning rates) and better robustness compared to e.g. the p

Critical role of Lama4 for hematopoiesis regeneration and acute myeloid leukemia progression

Impairment of normal hematopoiesis and leukemia progression are 2 well-linked processes during leukemia development and are controlled by the bone marrow (BM) niche. Extracellular matrix proteins, including laminin, are important BM niche components. However, their role in hematopoiesis regeneration and leukemia is unknown. Laminin α4 (Lama4), a major receptor-binding chain of several laminins, is

Distinctive Effects of D1 and D2 Receptor Agonists on Cortico-Basal Ganglia Oscillations in a Rodent Model of L-DOPA-Induced Dyskinesia

L-DOPA-induced dyskinesia (LID) in Parkinson’s disease has been linked to oscillatory neuronal activities in the cortico-basal ganglia network. We set out to examine the pattern of cortico-basal ganglia oscillations induced by selective agonists of D1 and D2 receptors in a rat model of LID. Local field potentials were recorded in freely moving rats using large-scale electrodes targeting three moto

Verification of multi-structure targeting in chronic microelectrode brain recordings from CT scans

Background: Large-scale microelectrode recordings offer a unique opportunity to study neurophysiological processes at the network level with single cell resolution. However, in the small brains of many experimental animals, it is often technically challenging to verify the correct targeting of the intended structures, which inherently limits the reproducibility of acquired data. New method: To mit