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The scaffold protein p140Cap limits ERBB2-mediated breast cancer progression interfering with Rac GTPase-controlled circuitries

The docking protein p140Cap negatively regulates tumour cell features. Its relevance on breast cancer patient survival, as well as its ability to counteract relevant cancer signalling pathways, are not fully understood. Here we report that in patients with ERBB2-amplified breast cancer, a p140Cap-positive status associates with a significantly lower probability of developing a distant event, and a

HRDetect is a predictor of BRCA1 and BRCA2 deficiency based on mutational signatures

Approximately 1-5% of breast cancers are attributed to inherited mutations in BRCA1 or BRCA2 and are selectively sensitive to poly(ADP-ribose) polymerase (PARP) inhibitors. In other cancer types, germline and/or somatic mutations in BRCA1 and/or BRCA2 (BRCA1/BRCA2) also confer selective sensitivity to PARP inhibitors. Thus, assays to detect BRCA1/BRCA2-deficient tumors have been sought. Recently,

NF1-mutated melanoma tumors harbor distinct clinical and biological characteristics

In general, melanoma can be considered as a UV-driven disease with an aggressive metastatic course and high mutational load, with only few tumors (acral, mucosal, and uveal melanomas) not induced by sunlight and possessing a lower mutational load. The most commonly activated pathway in melanoma is the mitogen-activated protein kinase (MAPK) pathway. However, the prognostic significance of mutation

Implementation of the Kyoto Targets in Lithuania from a Perspective of Multi-level Governance

The first year with a Down syndrome infant - A Thematic analysis of parents´ representations.

Focus on the parents´ representations of a disabled infant.

Reaching the level of parents´ representatins - A prerequisite for early intervention?

Breast reconstruction: (Re)making the normal as a practical measure, magic ritual or risky procedure?”

Hur blir det normala normalt? Exempel från plastikkirurgin

Contemporary Scandinavian Cinema between Art and Commerce

With regard to Scandinavian cinema and television, the last decades have been marked by the unexpected international appeal and unforeseen longevity of Scandinavian crime or Nordic noir as it is sometimes labeled. This development has paved the way for ever increasing financial and artistic collaboration within the audiovisual industries, especially among the Scandinavian countries. But it has als

Designing for the future : making instruments for European Spallation Source

What do the SSRI pills do? users experiences of antidepressants at the crossroads of bodies, minds and medicine

“Theoretical tensions in (re)making “the normal”. Studying plastic surgery and talking with STS and feminist theory

The emergence of “fear of childbirth” as an obstetric problem, an answer to women's demand for caesarean section?”

Bodies out of place – reflections from a failed ethnographic fieldwork

Distal Radius Fractures. Outcome and New Methods of Surgical Treatment

Handledsbrott är den vanligaste frakturen på en akutmottagning. De yngre vuxna patienterna är jämnt fördelade mellan könen men de äldre har en övervikt av kvinnor. Hos de äldre men även i medelåldern uppstår frakturen företrädesvis i ett skelett med olika grad av benskörhet. Frakturen behandlas oftast med gips utan operation men drygt en femtedel opereras. Om felställningen är stor eller om fraktu

What do the antidepressants do? Users experiences at the crossroads of bodies, minds and medicine

Effects of collaboration with a non witness on the metacognitive realism and confidence of an eye-witness

A longitudinal study on the implications of collaboration with a non-witness on eyewitnesses’ accuracy and metacognitive realism

Workplace Incivility and Job Satisfaction in the Context of the School Environment