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Hematopoietic stem cells (HSCs) cultured outside the body are the fundamental component of a wide range of cellular and gene therapies. Recent efforts have achieved > 200-fold expansion of functional HSCs, but their molecular characterization has not been possible since the majority of cells are non-HSCs and single cell-initiated cultures have substantial clone-to-clone variability. Using the Fgd5
One of the most challenging aspects of stem cell research is the reliance on retrospective assays for ascribing function. This is especially problematic for hematopoietic stem cell (HSC) research in which the current functional assay that formally establishes its HSC identity involves long-term serial transplantation assays that necessitate the destruction of the initial cell state many months bef
Haematopoietic stem cell (HSC) self-renewal is a process that is essential for the development and homeostasis of the blood system. Self-renewal expansion divisions, which create two daughter HSCs from a single parent HSC, can be harnessed to create large numbers of HSCs for a wide range of cell and gene therapies, but the same process is also a driver of the abnormal expansion of HSCs in diseases
An increasingly large part of the population in the West identifies as religious Nones. Contrary to what might be assumed, most of them are not outright atheists. They reject traditional religion, but many pursue different forms of spirituality, and many entertain supernatural ideas. This element concerns the worldview of these “semi-secular” Nones. When asked about whether they believe in God, th
This study explores Buddhist monks’ views on the religion-science relationship in contemporary China. Drawing on survey data, interviews with monks, and participant observation within Shaolin Temple – famous for its antiquity and its export of Shaolin Kungfu – we discern and theoretically account for two forms of ‘non-conflict,’ between science and religion, that shape monks’ mental lives. One gro
Denna artikel analyserar Jessica Schiefauers spekulativa roman Bärarna (2020) och diskuterar konsekvenserna av att bygga ett samhälle utifrån smittoprevention. Romanen skildrar en framtid där en rabiesliknande sjukdom hotat att utplåna mänskligheten. I denna dystopi har män, som spridare av smittan, och kvinnor separerats för att förhindra återkomsten av sjukdomen. Artikeln undersöker hur romanen This article analyses Jessica Schiefauer’s speculative novel Bärarna (2020), and examines the consequences of building a society based on disease pre-vention. The novel depicts a future where a rabies-like disease has nearly wiped out humanity. In this dystopia, men, as carriers of the disease, are separated from women to prevent the resurgence of the illness. The article investigates how the nove
This article discusses how fiction and its collisions between different linguistic registers have both literary and pedagogical potential. Taking its point of departure in literary texts used in the medical humanities teaching at the medical school at Lund University, various types of collisions between literary language and medical language are analysed. To conceptualize the collisions between th
To be a caregiver while also being next of kin is emotionally charged. This article discusses narratives of care that goes beyond what Amelia DeFalco calls “caregiving at the limit”, i.e. care necessary for basic survival. In these narratives of what we call desperate care, not only is life at stake, but the care is anxious and urgent, partly done against the will of the care recipient, and the ca
BACKGROUND: Telehealth services are becoming increasingly popular at primary healthcare centres. Some examples include text-based digital triage and health guidance using chats, emails, images and pre-filled forms. Telephone-based communication has until recent years been the predominant means for triage and health guidance, but now includes written communication via computer or smartphone. Hence
Many conservative public figures have claimed that Google Search exhibits a liberal bias in the links presented. Surprisingly, perhaps, the few scientific studies conducted so far have tended to support this claim. In the study reported here, we compared Google search engine result pages (SERPs) for 8 terms related to immigration across 8 geographically distinct locations (municipalities). For eac
Hjem (Home) is an exhibition showcasing the works of Sverre Bjertnæs, featuring around 40 paintings and sculptures, both old and new. The exhibition was curated by Fredrik Værslev in the spring of 2024. Bjertnæs is one of Norway's foremost painters and sculptors.
Background: Fungal DNA is rarely reported in metagenomic studies of ancient samples. Although fungi are essential for their interactions with all kingdoms of life, limited information is available about ancient fungi. Here, we explore the possibility of the presence of ancient fungal species in the gut of Ötzi, the Iceman, a naturally mummified human found in the Tyrolean Alps (border between Ital
In Comfort Women of the Japanese Empire: Colonial Rule and the Battle over Memory, Park Yuha offers a provocative reassessment of the ‘comfort women’ issue – first proposed over a decade ago in the Korean version of this book. Situated at the heart of one of the most contentious debates in East Asian historiography, the book examines the enduring legacies of Japan’s colonial rule and its impact on
The EU regulation on Deforestation-Free Products (EUDR) enacted in 2023 aims to reduce deforestation connected to commodities imported to the EU, including cattle products. In Brazil, the EUDR pressures the local cattle supply chain towards more sustainable production. However, the potential effects of the EUDR on reducing deforestation in this sector are unclear and require scrutiny. Drawing on t
Ni-based superalloys, essential for high-temperature applications, derive strength from coherent second-order precipitates that impede dislocation motion through coherency misfit and elastic mismatch. This study employs multi-component phase-field crystal (PFC) simulations to explore the elastic deformation of such precipitates. Using a binary ordered square structure for the precipitate and a sin
Background: Peripartum asphyxia affects three to five per 1000 live births, with moderate or severe hypoxic ischemic encephalopathy (HIE) occurring in 0.5 to 1 per 1000 live births, and is associated with high mortality and morbidity. Therapeutic hypothermia is an effective treatment, but alternative therapies such as acupuncture are also used. Objectives: To determine the benefits and harms of ac
Conceived as a catalogue and an artist’s book, the publication was made on occasion of the eponymous 2022 exhibition at Indipendenza Roma. Deeply responsive to the space, the exhibition brought together works by Louise Lawler and Fredrik Værslev to explore the tension between an artwork and its surrounding architectural context, spurring questions of taste, value, function, and decoration.
In 2021, the International Monetary Fund (IMF) moved to integrate climate risks into its Article IV surveillance of member states. While the IMF has not traditionally been at the forefront of climate change efforts, this decision involved defining climate change as a risk to macro-economic stability. I argue that the integration of climate change into IMF surveillance can be understood as a case o
