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Transcriptional deregulation of myc in IgH/myc 6;7 translocation carrying rat immunocytomas

We have previously shown that the reciprocal translocation t(6;7) associated with the spontaneous immunocytoma of the Louvain rat (RIC) leads to the juxtaposition of myc to the IgH cluster. In 10 of 14 tumors investigated the breakpoints on the myc carrying chromosome were clustered in a 1.5 kb region 5' of the intact gene, proximal to the myc promoters. In this paper we describe the effect of the

Exploring Outward FDI and the Choice of Destination: Evidence from Swedish Firm-Level Data

Using Swedish firm-level data on all firms and their affiliates abroad, we investigate what observable firm and country characteristics affect the size of affiliate firms in a particular destination. We employ the richness of the data to investigate the importance of destination country factors in explaining firm outward FDI activities and distinguish between the factors that affect such activitie

Reflexive Leadership : Organising in an imperfect world

Making a case for a reflexive approach to leadership, the authors draw upon decades of carrying out indepth studies of professionals trying to “do” leadership. Through interviews with managers and their subordinates, getting a good understanding of organizational context, and critically interpreting their observations considering both leadership theories and a wealth of other perspectives, their c

Performance Evaluation of Lighting and Daylighting Retrofits: Results from IEA SHC Task 50

This article presents some results from a large monitoring campaign performed in 22 buildings around the world as part of International Energy Agency (IEA) Task 50 “Advanced lighting solutions for retrofitting buildings”. This article mainly addresses the work of Subtask D, which aims to demonstrate sound lighting retrofit solutions in a selection of representative, typical Case Studies. In order

Urban environment shortens telomere length in nestling great tits, Parus major

Urban environments are expanding rapidly, and with urbanization come both challenges and opportunities for wildlife. Challenges include combating the anthropogenic disturbances such as light, noise and air pollution and lower availability of natural food sources. The benefits are many, including the availability of anthropogenic food sources, breeding boxes and warmer temperatures. Thus, depending

Percy Shelley's 'Unfinished Drama' and the Problem of the Jane Williams Poems

This essay returns to the extensive scholarly debate surrounding the lyrics and fragments which Percy Bysshe Shelley composed for Jane Williams, or with her in mind, during the last six months of his life. It takes its point of departure in what it defines as “the problem of the Jane Williams poems” – the difficulty, faced by biographers, editors, and critics alike, of mapping the relationship bet

Increased deep pain sensitivity in persistent musculoskeletal pain but not in other musculoskeletal pain states

BackgroundPressure pain thresholds (PPTs) in a non-painful body area are known to be affected in some chronic pain states. The aim of this study is to investigate PPTs in a pain-free body part in relation to pain persistence and intensity in patients with musculoskeletal pain. MethodsPatients with musculoskeletal pain were divided into three different pain groups: acute pain (pain duration 3 mont

Long-term risk of renal and urinary tract diseases in childhood cancer survivors : A population-based cohort study

Background Childhood cancer has been associated with long-term risk of urinary tract diseases, but risk patterns remain to be comprehensively investigated. We analysed the lifetime risk of urinary tract diseases in survivors of childhood cancer in the Nordic countries. Methods We identified 32,519 one-year survivors of childhood cancer diagnosed since the 1940s and 1950s in the five Nordic cancer

The Potential of Bootstrapping Research for Advancing the Understanding of the Role of Resources in Corporate Entrepreneurship

Over the years we have seen an increased interest in businesses and in research for how to create conditions for entrepreneurship in established businesses (referring to corporate entrepreneurship). From research we know that access to and use of resources is critical for realizing corporate entrepreneurship activities. Even though the role of resources has been examined this conceptual paper iden

Improving the current risk analysis techniques by study of their process and using the human body's immune system

Risks include the factors that might adversely affect project outcomes. Risk analysis includes the processes concerned with identifying, analyzing and developing security strategy and plans for the factors. Although currently there are known methodologies such as (CCTA Risk Analysis and Management Method (CRAMM) or Consultative, Objective and Bi-functional Risk Analysis(COBRA) and so on) for Risk