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Introduction: Treatment-induced peripheral neuropathy (TIPN) is a complication of multiple myeloma (MM) treatment. Objective: This real-world, retrospective study used electronic medical record (EMR) data from 3 Swedish clinics to assess the occurrence and economic burden of TIPN in patients with MM. Methods: Eligible patients had an MM diagnosis in the Swedish Cancer Registry between 2006 and 201
BackgroundEvaluation of emergency department (ED) performance remains a difficult task due to the lack of consensus on performance measures that reflects high quality, efficiency, and sustainability.AimTo describe, map, and critically evaluate which performance measures that the published literature regard as being most relevant in assessing overall ED performance.MethodsFollowing the PRISMA guide
Background: The 2017 Alzheimer’s disease (AD) Strategic Biomarker Roadmap (SBR) structured the validation of AD diagnostic biomarkers into 5 phases, systematically assessing analytical validity (Phases 1–2), clinical validity (Phases 3–4), and clinical utility (Phase 5) through primary and secondary Aims. This framework allows to map knowledge gaps and research priorities, accelerating the route t
This article explores news satire engagement and civic motivation, an area of concern in satire scholarship. Focused on what audiences ‘do’ with media, the ways in which young adults who regularly engage in news satire construct political efficacy is studied. Using a qualitative contextualising audience study, including in-depth interviews and focus groups with 31 young adults, a thematic analysis
Unicellular photosynthetic golden algae called diatoms are one of the most abundant silicifying organisms. Diatoms take up silicon and build their frustules, in the form of biogenic silica (BSi), which have high preservation potential, and thus are found in sediments. Around 27 % of the annual dissolved silicon (DSi) delivery from the land to the ocean is retained in lakes and reservoirs in the fo
This article reviews the geology of the Sveconorwegian orogen in south Scandinavia and existing tectonic models for the Mesoproterozoic to Neoproterozoic Sveconorwegian orogeny. It proposes an updated geodynamic scenario of large, hot, long-duration continental collision starting at c. 1065 Ma between proto-Baltica and another plate, presumably Amazonia, in a Rodinia-forming context. An orogenic p
We report on a novel phenomenon of particle cosmology, which features specific cosmological phase transitions via quantum tunnelings through multiple vacua. The latter is inspired by the axiverse ideas, and enables to probe the associated new physics models through a potential observation of specific patterns in the stochastic gravitational waves background. Multiple vacua may induce the nucleatio
Androgen deprivation therapy (ADT) with gonadotropin-releasing hormone (GnRH) agonists and antagonists is the mainstay of advanced prostate cancer treatment. Both drug classes decrease levels of luteinizing hormone and follicle-stimulating hormones (FSH), thereby lowering testosterone to castrate levels. This is associated with adverse events (AEs), including cardiovascular (CV) disorders, bone fr
Objectives: To explore the preoperative, intraoperative, and postoperative dynamics of heparin-binding protein (HBP) in cardiothoracic surgery. Design: This was a prospective, observational study. Setting: The study was conducted at a single university hospital. Participants: Thirty patients undergoing cardiac surgery with cardiopulmonary bypass (CPB) were included, 15 of whom underwent coronary a
The relative role of natural selection and genetic drift in evolution is a major topic of debate in evolutionary biology. Most knowledge spring from a small group of organisms and originate from before it was possible to generate genome-wide data on genetic variation. Hence, it is necessary to extend to a larger number of taxonomic groups, descriptive and hypothesis-based research aiming at unders
Genome scans in recently separated species can inform on molecular mechanisms and evolutionary processes driving divergence. Large-scale polymorphism data from multiple species pairs are also key to investigate the repeatability of divergence-whether radiations tend to show parallel responses to similar selection pressures and/or underlying molecular forces. Here, we used whole-genome resequencing
The Christian monastic tradition has its origins in the Middle East. It has been and remains a constitutive institution in the Oriental Orthodox Churches, which are the Armenian, Coptic, Ethiopian, and Syrian Orthodox Churches. In Armenia, Egypt, Ethiopia, and the Syriac-speaking Christian traditions, the monasteries have been the most important educational institutions in which language and liter
On the basis of a critical survey of university strategies, it is argued that universities reify and objectify “world class” and turn it into absolute and precisely defined goals (location in ranking hierarchies, publication patterns, number of start-ups and licens-es, etc.) and that this in turn is based on a skewed reading of the ascendancy of some universities (notably leading US higher educati
En betongkonstruktion som skadas av alkalikiselreaktioner spricker, förlorar sin hållfasthet, och blir utsatt för andra typer av nedbrytningsprocesser som frostangrepp och urlakning. Syftet med denna sammanställning är att vägleda och sprida kunskap om olika materialmodeller som kan användas för analys av utveckling av skador som orsakas av alkalikiselreaktioner i betongkonstruktioner. Kunskapen k
Mönster i grönt undersöker sambanden mellan receptionen av Graham Greenes verk och 1900-talslitteraturens villkor, med särskilt hänseende till genremässiga och mediala hierarkier på den internationella bokmarknaden. Studien visar att komplexiteten i Greenes litteraturhistoriska position – där omfattningen och den internationella spridningen av hans verk lett till ett slags frikoppling från enskild
Aggregates cytotoxie for human cells in vitro were produced when adenovirus type 5 was mixed with homotypic rabbit antiserum against whole virus particles at a certain restricted virus-antibody ratio. The same degree of cytotoxicity was obtained with mixtures of the virus and an antiserum against purified fibres of adenovirus type 5 at a certain proportion. The cytotoxicity could be neutralized by
