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Introduction : Digital Methods and Experiential Approaches to the Past

In this chapter, the authors introduce the theme of computational/digital methods in the realm of sensory archaeologies. To this purpose, the concept of sensoriality and its relevance for the archaeological discourse is rediscussed. Key concepts such as perception of material culture help us in better defining possible modalities through which archaeologists can benefit from the use of formal meth

Serious Conflicts with Benign Outcomes? The Electoral Consequences of Conflictual Cabinet Terminations

Conflictual cabinet terminations are seismic events in democracies, but their consequences are understudied. I argue that the electoral impacts of conflictual cabinet terminations depend on voters’ perceptions of them. Terminations following non-policy conflicts are electorally costly. They signal parties’ deteriorating governing competence, which reduces parties’ vote shares. In contrast, termina

Don't air your dirty laundry: Party leadership contests and parliamentary election outcomes

Staging an open contest is a democratic method to choose a party leader, though its electoral consequences remain unclear. I argue that leadership contests are electorally detrimental to governing parties. Competitive contests signal intraparty policy and/or personality conflict to voters, which damages governing parties’ perceived unity as well as competence in the policy-making process. Thus, le

More spotlight, more problems? Westminster parliamentary systems and leadership replacement in large opposition parties

In this article, I argue that Westminster parliamentary systems encourage large opposition parties to replace their leaders between elections. Parliamentary system structures how parties compete over legislative outcomes. In Westminster systems, the government’s dominance in the legislative process promotes an adversarial government–opposition relationship. Subsequently, large opposition parties’

New insight into myocardin regulation and function in smooth muscle cells

Smooth muscle cells (SMCs) are constituents of hollow inner organs. Their contractile function governs essential physiological functions, such as breathing, eating, blood pressure control, urination, and childbirth. Skeletal and cardiac muscle cells are terminally differentiated cell types, but SMCs are highly plastic and change their phenotype in disease. Cues presented by the microenvironment an

Attract voters or appease activists? Opposition parties’ dilemma and party policy change

Why do mainstream opposition parties sometimes fail to adopt policy positions that are attractive to the wider electorate? In this paper, I construct a game-theoretic model between the party leader, the party’s MPs, and the party organization to illustrate how opposition parties’ platform adjustments depend on the party leader’s risk assessment of being deposed and MPs’ re-election incentives. The

One size doesn't fit all: Voter decision criteria heterogeneity and vote choice

Although classic voting studies noted that voters may reach their voting decision on the basis of different criteria most contemporary voting studies assume that one voting model fits all. Building on the limited, but developing literature on the topic, this paper develops and tests models incorporating voter decision criteria heterogeneity. Paying particular attention to the role of voter sophist

The agenda-setting power of the prime minister party in coalition governments

Despite coalition governments being the most widespread form of government, many aspects of coalition politics are still poorly understood. This is especially true for questions relating to the role of the prime minister party within the coalition. Being the prime minister party seems to imply considerable influence, but little evidence actually exists as to the factors shaping the influence of th

Extended genetic analysis and tumor characteristics in over 4600 women with suspected hereditary breast and ovarian cancer

BACKGROUND: Genetic screening for pathogenic variants (PVs) in cancer predisposition genes can affect treatment strategies, risk prediction and preventive measures for patients and families. For decades, hereditary breast and ovarian cancer (HBOC) has been attributed to PVs in the genes BRCA1 and BRCA2, and more recently other rare alleles have been firmly established as associated with a high or

A search for modifying genetic factors in CHEK2:c.1100delC breast cancer patients

The risk of breast cancer associated with CHEK2:c.1100delC is 2-threefold but higher in carriers with a family history of breast cancer than without, suggesting that other genetic loci in combination with CHEK2:c.1100delC confer an increased risk in a polygenic model. Part of the excess familial risk has been associated with common low-penetrance variants. This study aimed to identify genetic loci

The Ethics of Outsourcing Information Conflict: Outlining the Responsibilities of Government Funders to their Civil Society Partners

This report investigates the roles and responsibilities governments assume when they collaborate in areas of information conflict. In particular, it assesses the risks to civil society and the private sector when they engage in countering hostile foreign influence operations with funding from governments. What are governments’ options and limitations when supporting civilian populations to counter

Sailing Along the Coast of North Etruria : Ancient Perceptions Versus Multidisciplinary Coastal Landscape Studies

Aim of this contribution is to demonstrate how digital methods, in combination with traditional sources, can effectively contribute to reconstruct a narrative of the past based on a sensory account of a few coastal landscapes in Northwestern Etruria as they were perceived and described by ancient authors. A few passages by Strabo (Geogr. 5.2.5, 222C, Augustan period) and Rutilius Namatianus (de re

Management of paraesophageal hiatus hernia : recommendations following a European expert Delphi consensus

AIMS: There is considerable controversy regarding optimal management of patients with paraesophageal hiatus hernia (pHH). This survey aims at identifying recommended strategies for work-up, surgical therapy, and postoperative follow-up using Delphi methodology.METHODS: We conducted a 2-round, 33-question, web-based Delphi survey on perioperative management (preoperative work-up, surgical procedure

Methotrexate use among men-association with fertility and the perinatal health of their children: a Swedish nationwide register study

OBJECTIVE: To study the effect of methotrexate on male fertility and subsequent effects on their children, for which data are scarce and contradictory.DESIGN: Nationwide multiregister cohort study.SETTING: Not applicable.SUBJECT(S): All children born alive in Sweden between 2006 and 2014 and their fathers. Three cohorts were defined: children to fathers with periconceptional methotrexate exposure

Mechanisms for the Influence from Ice Nucleus Aerosols on Clouds and their Indirect Effects: Cloud Modelling

The role of multiple groups of primary biological aerosol particles (PBAPs) as ice nucleating particles (INPs), and of ice formation processes such as time-dependent freezing of various INPs, and various secondary ice production(SIP) mechanisms in overall ice concentration has been evaluated in a range of cloud systems by simulating them numerically with the state-of-the-art ‘Aerosol-Cloud’ (AC) m