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Microwave-induced hyperthermia and radiotherapy in human superficial tumours: clinical results with a comparative study of combined treatment versus radiotherapy alone
Eighty-five evaluable superficial recurrent malignant tumours, mainly adenocarcinomas (78 per cent), in 38 patients were treated with either combined local hyperthermia (41-45 degrees C for four sessions) and low dose radiotherapy (30.0 Gy) or the same low dose radiotherapy alone. The treatment was given for two weeks. Hyperthermia was induced externally with 2450 MHz or 915 MHz microwaves. Totall
Using the functional response to determine the nature of unequal interference among foragers
The food intake rate of foragers may be reduced as a result of interference, which may be asymmetric among individuals and occur as a result of intimidation, direct aggression or filtering. It is important to distinguish among these types of interference, because each can have different consequences for individuals, foraging groups and populations. We demonstrate the application of the functional
Design of recombinant antibody microarrays for complex proteome analysis: Choice of sample labeling-tag and solid support
Antibody-based microarray is a novel technology with great potential within high-throughput proteomics. The process of designing high-performing antibody (protein) microarrays has, however, turned out to be a challenging process. In this study, we have developed further our human recombinant single-chain variable-fragment (scFv) antibody microarray methodology by addressing two crucial technologic
Geriatric rheumatoid arthritis patients on delayed anti-TF-alpha agents have higher disease activity and experience more often serious adverse events compared to younger adults
Fe-57 Mossbauer effect study of bannisterite: a modulated 2 : 1-type phyllosilicate
Bannisterite is a modulated 2:1-type phyllosilicate having ten octahedral sites with hydroxyl groups in trans, cis and combined trans-cis configurations. Each octahedral site, depending on its proximity to the layer modulation, is exposed to a different degree of distortion. The electric field gradient at the Fe site and the site distortion are used to propose a model for the site assignment and o
Practice patterns in haemophilia A therapy - global progress towards optimal care
This paper reports the findings of a global survey of practice patterns for the management of patients with haemophilia A. A total of 147 haemophilia treatment centres worldwide responded to the questionnaire, supplying data for 16 115 patients with haemophilia A. From these responses, 38% (range: 25-48%) of patients were under 18 years old. Almost half (47%) of patients were reported to have mild
Roles of the plasminogen activator streptokinase and the plasminogen-associated M protein in an experimental model for streptococcal impetigo
Primary infection by group A streptococci (GAS) takes place at either the throat or skin of the human host, often leading to pharyngitis or impetigo, respectively. Many GAS strains differ in their preference for throat and skin tissue sites. Previous epidemiological findings show that many of the strains displaying strong tropism for the skin have a high-affinity binding site for plasminogen, loca
Effects of data uncertainties on estimated soil organic carbon in the Sudan
Estimating the rate of soil carbon sequestration in degraded semiarid agroecosystems is of great interest due to the beneficial effects on soil properties, soil fertility, and the potential atmospheric CO2 mitigation. One of several applied methodologies, biogeochemical modeling, offers possibilities to distribute estimates of soil organic carbon (SOC) over regions, estimate the effects of changes
The role of P fimbriae for Escherichia coli establishment and mucosal inflammation in the human urinary tract.
Lack of relationship between beta-hexosaminidase activity and retinopathy in insulin dependent diabetics
Beta-hexosaminidase activity in plasma and urine was measured and compared in insulin dependent diabetics (IDDM) with and without proliferative retinopathy. No difference in the activity of beta-hexosaminidase was found between the two groups indicating that this enzyme is not involved in the development of diabetic microangiopathy.
Two genome-wide linkage disequilibrium screens in Scandinavian multiple sclerosis patients
We report the first two genome-wide screens for linkage disequilibrium between putative multiple sclerosis (MS) susceptibility genes and genetic markers performed in the genetically homogenous Scandinavian population, using 6000 microsatellite markers and DNA pools of approximately 200 MS cases and 200 controls in each screen. Usable data were achieved from the same 3331 markers in both screens. N
Maturitas, the european menopause journal, becomes 'Official journal of the european menopause and andropause society'
Why do inhibitors develop? Principles of and factors influencing the risk for inhibitor development in haemophilia.
The formation of inhibitory alloantibodies is, in the postinfectious era, the most severe and costly complication of replacement therapy in patients with haemophilia. The complexity of the immune response to the infused factor becomes more and more obvious as knowledge in the area increases. Antibodies develop as a result of a complex multi-factorial interaction between antigen-presenting cells, T
Differences in metabolic regulation between glucose responsive INS-1 832/13 and its glucose non-responsive INS-1 832/2 sister clonal rat beta cell line decides their beta cell functionality
Simulating vegetation cover dynamics with regards to long-term climatic variations in sub-arctic landscapes
Iceland is facing severe land degradation in many parts of the country. This study aims to increase the understanding of the complex interactions and interconnectivity between the critical factors that help maintain the land degradation processes in sub-arctic environments. A holistic approach in the form of a causal loop diagram (CLD) is applied for diagnosing the influencing factors. To further
Synthesis and surface characteristics of CeTbO3+delta induced by femtosecond laser irradiation
This work describes the use of focused, high-intensity light from a Ti: sapphire laser that generates femtosecond pulses to irradiate mixture of CeO2 and Tb4O7 under ambient conditions. The prepared samples were investigated by means of X-ray diffraction (XRD), X-ray photoelectron spectroscopy (XPS) and scanning electron microscope (SEM). XRD and XPS measurement results demonstrated that solid sol
General practitioners' conceptions of depressive disorders in relation to regional sales levels of antidepressive drugs. A study based on a postal survey and ecological data.
Growth of juvenile Atlantic cod Gadus morhua in land-based recirculation systems. Effects of feeding regime, photoperiod and diet
The combined effect of feeding regime and photoperiod on the growth of juvenile Atlantic cod Gadus morhua in land-based recirculating aquaculture systems (RAS) was examined using three different commercial diets. Fish of 8-10 g were reared in 1 m³ tanks at an initial density of 10 kg m-³ for 78 d. Three RAS units were used to simultaneously test three feed/photoperiod regimes that might be encount
Probiotic strains of Lactobacillus and Bifidobacterium affect the translocation and intestinal load of Enterobacteriaceae differently after D-galactosamine-induced liver injury in rats
In an acute liver injury model we compared the effects of different Lactobacillus and Bifidobacterium strains on bacterial translocation, intestinal load of Enterobacteriaceae and the extent of liver injury. This was an experimental study carried out in an university hospital in Sweden. Sprague-Dawley rats were divided into six groups: liver injury control and five groups of liver injury with admi