Mutations in the BRAF oncogene occur in the majority of melanomas, leading to the activation of the mitogen-activated protein kinase pathway and the transcription of downstream effectors. As BRAF and its effectors could be good melanoma therapy targets, defining the repertoire of genes that are differentially regulated because of BRAF mutational activation is an important objective. Towards this g

Visually striking nanoflowers composed of ZnS:Mn2+ nanoparticles are prepared and characterized. The configurations of these fractal structures are very sensitive to both the pH values of the particle solutions from which they are precipitated and the substrates on which they are deposited. At pH 2.2, the fractal structures resemble trees without leaves; at pH 7.7, they are tree-like with four arm

Pheromone-based mating disruption of the almond moth (Ephestia cautella) (Walk.) (Lepidoptera: Pyralidae) was carried out in a chocolate factory in Sweden. Population monitoring was conducted with pheromone-baited traps and water traps. Pheromone traps showed a 94% catch reduction, and monitoring with water traps showed a significant decrease in total catch (5.0 and 1.6 individuals per trap per we

In the decade since their discovery, the two major breast cancer susceptibility genes BRCA1 and BRCA2, have been shown conclusively to be involved in a significant fraction of families segregating breast and ovarian cancer. However, it has become equally clear that a large proportion of families segregating breast cancer alone are not caused by mutations in BRCA1 or BRCA2. Unfortunately, despite i

We have used magnetic relaxation dispersion to study bovine pancreatic trypsin inhibitor (BPTI) self-association as a function of pH, salt type and concentration, and temperature. The magnetic relaxation dispersion method sensitively detects stable oligomers without being affected by other interactions. We find that BPTI decamers form cooperatively under a wide range of solution conditions with no

The EUROGIN 2008 Roadmap represents a continuing effort to provide updated information on primary and secondary prevention of cervical cancer. The report addresses several areas including the progress made toward global implementation of currently licensed human papillomavirus (HPV) vaccines, the possibilities and value of future-generation HPV vaccines. endpoints under consideration for evaluatio

Allozyme variation in the forest grass Milium effusum L. was studied in 21-23 populations within each of two equally sized densely sampled areas in northern and southern Sweden. In addition, 25 populations from other parts of Eurasia were studied for comparison. The structure of variation was analysed with both diversity statistics and measures based on allelic richness at a standardised sample si

A prospective study of normoalbutninuric diabetic patients was performed between 1997 and 2002 on 4097 type 1 and 6513 type 2 diabetic patients from the Swedish National Diabetes Register (NDR); mean study period, 4.6 years. The strongest independent baseline risk factors for the development of microalbuminuria (20-200 mug/min) were elevated HbA(1c) and diabetes duration in both types 1 and 2 diab

The linewidth in intersubband transitions can be significantly reduced below the sum of the lifetime broadening for the involved states, if the scattering environment is similar for both states. This is studied within a nonequilibrium Green function approach here. We find that the effect is of particular relevance for a recent, relatively low doped, Terahertz quantum-cascade laser.

The magnetic map hypothesis proposes that animals can use spatial gradients in the Earth's magnetic field to help determine geographic location. This ability would permit true navigation--reaching a goal from an entirely unfamiliar site with no goal-emanating cues to assist. It is a highly contentious hypothesis since the geomagnetic field fluctuates in time and spatial gradients may be disturbed

Although an autonomous mobile ad hoc network (MANET) is useful in many scenarios, a MANET connected to the Internet is more desirable. This interconnection is achieved by using gateways, which act as bridges between a MANET and the Internet. Before a mobile node can communicate with an Internet host it needs to find a route to a gateway. Thus, a gateway discovery mechanism is required. In this pap

Terrestrial ecosystems sequester 2.1 Pg of atmospheric carbon annually. A large amount of the terrestrial sink is realized by forests. However, considerable uncertainties remain regarding the fate of this carbon over both short and long timescales. Relevant data to address these uncertainties are being collected at many sites around the world, but syntheses of these data are still sparse. To facil

The application of scattering methods in the study of biological and biomedical problems is a field of research that is currently experiencing fast growth. In particular, neutron reflectometry (NR) is a technique that is becoming progressively more widespread, as indicated by the current commissioning of several new reflectometers worldwide. NR is valuable for the characterization of biomolecules

Group B Neisseria meningitidis is a human pathogen, for which a universally effective vaccine is still not available. Immune responses to bacteria are initiated by dendritic cells (DC), which internalize and process bacterial antigens for presentation to T cells. We show here that optimal IL-12 and TNF-alpha production by human monocyte derived DC in response to killed serogroup B N. meningitidis