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An institutional perspective on sustainability transitions

This chapter introduces an institutional perspective on sustainability transitions. Sustainability transitions entail the destabilization and de-institutionalization of existing socio-technical regimes in various industries and the creation and diffusion, hence institutionalization, of new, potentially more sustainable socio-technical configurations. Institutional theory thus provides excellent in

An Institutional Logics Perspective on the Gig Economy

We witness rising tensions between online gig-economy platforms, incumbent firms, regulators, and labor unions. In this chapter, we use the framework of institutional logics as an analytical lens and scheme to understand the fundamental institutional challenges prompted by the advent of the online gig economy. We view gig-economy platforms as corporations that organize and self-regulate markets. I

The Rise of Online Platforms and the Triumph of the Corporation

Rather than viewing online platforms as digital marketplaces, we analyze platforms as corporations and platform participants as a workforce. Online platforms perform very similar functions as any other corporation, but in different ways (applying terms and conditions as a legal framework and data, reviews, and algorithms for decentralized control) and mostly in different contexts (informal labor m

Spatial and socio-economic analysis of public transport systems in large cities : A case study for Belo Horizonte, Brazil

The main goal of this article is to evaluate the relationship between the spatial distribution of the population of the city of Belo Horizonte, one of the largest cities in South America, and its public transport network, seeking to ascertain whether the current bus network is able to meet the needs of the population. The methodology was based on data processing and vector information from differe

Centrality dependence of J/ψ and ψ(2S) production and nuclear modification in p-Pb collisions at √sNN = 8.16 TeV

The inclusive production of the J/ψ and ψ(2S) charmonium states is studied as a function of centrality in p-Pb collisions at a centre-of-mass energy per nucleon pair sNN = 8.16 TeV at the LHC. The measurement is performed in the dimuon decay channel with the ALICE apparatus in the centre-of-mass rapidity intervals −4.46 < ycms< −2.96 (Pb-going direction) and 2.03 < ycms< 3.53 (p-going direction),

Plasma exchange in ANCA-associated vasculitis : the pro position

Plasma exchange (PLEX) is capable of removing significant amounts of circulating antibodies. In anti-neutrophil cytoplasmic antibody-associated vasculitis, PLEX was reserved for patients with severe presentation forms such as rapidly progressive glomerulonephritis and pulmonary haemorrhage. The Plasma Exchange and Glucocorticoids in Severe ANCA-Associated Vasculitis (PEXIVAS) trial included all co

Vasoactive Biomarkers Associated With Long-Term Incidence of Symptomatic Peripheral Arterial Disease and Mortality

We evaluated if plasma biomarkers can predict incident peripheral arterial disease (PAD) and mortality in a longitudinal cohort study. Men (n = 3618) and women (n = 1542) were included in the Malmö Preventive Project and underwent analysis of: C-terminal endothelin-1 (CT-proET-1), N-Terminal prosomatostatin (NT-proSST), midregional proatrial natriuretic peptide (MR-proANP), procalcitonin (PCT), an

Association between circulating furin levels, obesity and pro-inflammatory markers in children

Aim: To, in children, investigate the associations between serum furin, obesity, overweight, body fat and circulating markers reflecting adipose tissue or systemic inflammation. Methods: We analysed furin, leptin, adipocyte fatty acid–binding protein, triglycerides, interleukin (IL)-6, IL-8 and C-reactive protein in serum from 166 children in the Pediatric Osteoporosis Prevention (POP) study colle

Circulating pro-neurotensin levels predict bodyweight gain and metabolic alterations in children

Background and aims: Neurotensin (NT) is an intestinal peptide released after fat ingestion, which regulates appetite and facilitates lipid absorption. Elevated plasma levels of its stable precursor pro-neurotensin (pro-NT) are associated with type 2 diabetes, obesity and cardiovascular mortality in adult populations; no data on pro-NT and metabolic disease are available in children. Aim of the st

Characterisation of the genetic discordance between body mass index and type 2 diabetes: a phenome-wide analysis : No 111

Background and aims: Obesity is on the rise globally, and is a leading risk factor for T2D. However, it is very heterogeneous, with varying degrees of T2D risk within the same levels of BMI. Better classification may lead to improve outcomes of current preventive and therapeutic strategies. Moreover, by elucidating the mechanisms uncoupling obesity from T2D risk, new possible therapeutic targets m

Light, flight and the night : effect of ambient light and moon phase on flight activity of pteropodid bats

Fruit-feeding pteropodid bats roost under varying light conditions. Some roost in trees with high exposure to daylight (> 1000 lx), while others roost in dark caves (< 0.1 lx). To understand the effect of ambient light intensity and moon phase on flight activity, we examined flight times across five lunar cycles in three pteropodid species whose roosts differ in daylight exposure. We found signifi

Haemophilia early arthropathy detection with ultrasound and haemophilia joint health score in the moderate haemophilia (MoHem) study

Introduction: Detection of early arthropathy is crucial for the management of haemophilia, but data on moderate haemophilia are limited. Therefore, we evaluated joint health and treatment modalities in Nordic patients with moderate haemophilia A (MHA) and B (MHB). Aim: To explore and compare the Haemophilia Early Arthropathy Detection with Ultrasound (HEAD-US) and Haemophilia Joint Health Score (H