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PM2.5 and Dementia in a Low Exposure Setting : The Influence of Odor Identification Ability and APOE

BACKGROUND: Growing evidence show that long term exposure to air pollution increases the risk of dementia. OBJECTIVE: The aim of this study was to investigate associations between PM2.5 exposure and dementia in a low exposure area, and to investigate the role of olfaction and the APOE ɛ4 allele in these associations. METHODS: Data were drawn from the Betula project, a longitudinal study on aging,

A hybrid approach to assess the structural impact of long noncoding RNA mutations uncovers key NEAT1 interactions in colorectal cancer

Long noncoding RNAs (lncRNAs) are emerging players in cancer and they entail potential as prognostic biomarkers or therapeutic targets. Earlier studies have identified somatic mutations in lncRNAs that are associated with tumor relapse after therapy, but the underlying mechanisms behind these associations remain unknown. Given the relevance of secondary structure for the function of some lncRNAs,

Coordination of courses in university programmes and students’ experiences of their studies : student perspectives on the importance of course coordination

This article examines how university students assess the coordination of the courses their programmes contain and how course coordination affects how content they are with their studies. The study is based on survey data from more than 5700 students, collected through Lund University’s Student Barometer. The survey examines the students’ views on course coordination based on content, workload, adm

Hur kan det svenska skattesystemet bli mer konkurrenskraftigt?

Det svenska skattesystemet står inför en rad utmaningar, både inhemska ochinternationella, och behöver reformeras för att möta dessa. Mycket har häntsedan århundradets skattereform i början av 1990-talet när det gäller såvälden värld vi lever i som förändringar i skattesystemet och kunskapen kringskatters effekter på beteende. För att Sverige ska vara konkurrenskraftigt ochkunna vidmakthålla en hö

Associations between dietary patterns and dementia-related neuroimaging markers

BACKGROUND: The exploration of associations between dietary patterns and dementia-related neuroimaging markers can provide insights on food combinations that may impact brain integrity. METHODS: Data were derived from the Swedish Gothenburg H70 Birth Cohort Study (n = 610). Three dietary patterns were obtained using principal component analysis. Magnetic resonance imaging markers included cortical

Outpatient vs inpatient induction of labor with oral misoprostol : A retrospective study

Introduction: Induction of labor is one of the most common obstetrical procedures today, with a successively rising rate. With a limited number of hospital beds, the option of starting induction at home has gained increasing attention. The primary aim of this study was to compare the proportion of women achieving vaginal delivery and the duration of hospital stay before delivery in induction of la

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This document details the main economic benefits of the blue economy of Ibiza and Formentera (Henceforth the “Pitiusas”). The main ecosystem services that the marine environment provides on both islands are identified, and the economic benefits estimated. The final objective of this study is to support the design of a sustainable blue economy strategy in the islands, in line with the Agenda 2030 a

Interpretation threshold values for patient-reported outcomes in patients participating in a digitally delivered first-line treatment program for hip or knee osteoarthritis

ObjectiveEstablish proportions of patients reporting important improvement, acceptable symptoms and treatment failure and define interpretation threshold values for pain, patient-reported function and quality-of-life after participating in digital first-line treatment including education and exercise for hip and knee osteoarthritis (OA).MethodsObservational study. Responses to the pain Numeric Rat

Towards a Deflationary Truthmakers Account of Social Groups

I outline a deflationary truthmakers account of social groups. Potentially, the approach allows us to say, with traditional ontological individualists, that there are only pluralities of individuals out there, ontologically speaking, but that there are nevertheless colloquial and social-scientific truths about social groups. If tenable, this kind of theory has the virtue of being both ontologicall

Expression of Cartilage Oligomeric Matrix Protein in colorectal cancer is an adverse prognostic factor and correlates negatively with infiltrating immune cells and PD-L1 expression

INTRODUCTION: Cartilage Oligomeric Matrix Protein (COMP) is an oncogenic protein that has been associated with a decrease in infiltrating T-cells in periampullary adenocarcinoma. This study aimed to investigate whether this is also the case for colorectal cancer (CRC) and to evaluate the relationship between COMP expression and clinopathological features.METHODS: Immunohistochemistry was used to d

Elements of cognition for general intelligence

What can artificial intelligence learn from the cognitive sciences? We review some fundamental aspects of how human cognition works and relate it to different brain structures and their function. A central theme is that cognition is very different from how it is envisioned in classical artificial intelligence which offers a novel path toward intelligent systems that in many ways is both simpler an

Self-management from the perspective of people with stroke – An interview study

ObjectiveSelf-management support can improve quality of life, mood, self-efficacy, and physical function following a stroke. Knowledge of how people with stroke understand and experience self-management in different contexts is crucial to developing effective self-management support. This study explored how people with stroke understand and practice self-management during the post-acute phase.Meth

Etikprövningslagen och funktionsrättskonventionen: normkonflikter och reformbehov

Huvudsyftet med etisk reglering av forskning på människor har alltid varit att skydda dessa. Vissa grupper, såsom personer med nedsatt beslutsförmåga, har setts som sårbara och därför i behov av särskilda skyddsregler. Nyligen har dessa regler kritiserats för att vara överbeskyddande, försvåra viktig forskning, och bryta mot mänskliga rättigheter, såsom FN:s Konvention om rättigheter för personer