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Direct electron transfer between copper-containing proteins and electrodes

The electrochemistry of some copper-containing proteins and enzymes, viz. azurin, galactose oxidase, tyrosinase (catechol oxidase), and the "blue" multicopper oxidases (ascorbate oxidase, bilirubin oxidase, ceruloplasmin, laccase) is reviewed and discussed in conjunction with their basic biochemical and structural characteristics. It is shown that long-range electron transfer between these enzymes

Aqueous polymer two-phase systems formed by new thermoseparating polymers

A set of new polymers that can be used as phase forming components in aqueous two-phase systems is presented. All polymers studied have thermoseparating properties i.e. form one separate polymer enriched phase and one aqueous solution when heated above the critical temperature. This property makes the polymers attractive alternatives to the polymers used in traditional aqueous two-phase systems su

Skalmurskonstruktionens fukt- och temperaturbetingelser

I rapporten beskrivs byggnadsfysikaliska mätningar i ett provhus med olika skalmurskonstruktioner. Mätningar har pågått under en 3-årsperiod och främst varit inriktade på fukt- och temperaturbetingelser i murverket, luftspalten, isoleringen och träreglarna.

The role of lipid rafts in LPS-induced signaling in a macrophage cell line.

The significance of lipid rafts in lipopolysaccharide (LPS) signaling in macrophages was studied through isolation of them by gradient centrifugation and subsequent visualization of signal molecules using antibodies. LPS signaling is initiated by binding to Toll-like receptor-4 (TLR4) and the co-receptor CD-14, leading to activation of downstream targets, such as MAP kinases. In this study, we sho

Analysis of the surface electrocardiogram for monitoring and predicting antiarrhythmic drug effects in atrial fibrillation

Specific antiarrhythmic therapy with class I and III drugs for atrial fibrillation (AF) conversion and prevention of its recurrence is frequently utilized in clinical practice. Besides being only moderate effective, the utilization of antiarrhythmic drugs may be associated with serious side effects. In the clinical setting it is difficult to directly evaluate the effects of antiarrhythmic drugs on

Molecular characterization of 3 MHC class II B haplotypes in the ring-necked pheasant

We investigated the class II B genes in a free-ranging population of the ring-necked pheasant Phasianus colchicus by a combination of restriction fragment length polymorphism (RFLP), polymerase chain reaction (PCR), and DNA sequencing. Special attention was paid to the variation in the second exon, which encodes the peptide-binding beta(i)-domain. The population was introduced, but it still exhibi

Recommendations for an update of the current (2001) regulatory requirements for registration of drugs to be used in the treatment of osteoporosis in postmenopausal women and in men

Recent advances in the understanding of the epidemiology of osteoporosis suggest that certain parts of the current European guidelines for the registration of drugs in osteoporosis might be no longer substantiated. The object of this review is to provide the European regulatory authorities with an evidence-based working document providing suggestions for the revision of the "Note for guidance for

Information and communication in society

In late modernity, the media is one of the most important social institutions in influencing people's knowledge, perceptions and actions. The media supply citizens with health-related messages and contribute thereby to their health development. The abundant flow of health-related messages, however, makes it difficult for the individual to separate good and reliable information from information of

In Defence of the Open Question Argument

The purpose of this paper is to defend G. E. Moore's open question argument, understood as an argument directed against analytic reductionism, the view that moral properties are analytically reducible to non-moral properties. In the first section I revise Moore's argument in order to make it as plausible and resistant against objections as possible. In the following two sections I develop the argu

Regeneration and plasticity in the brain and spinal cord.

The concept of brain plasticity covers all the mechanisms involved in the capacity of the brain to adjust and remodel itself in response to environmental requirements, experience, skill acquisition, and new challenges including brain lesions. Advances in neuroimaging and neurophysiologic techniques have increased our knowledge of task-related changes in cortical representation areas in the intact

The allyl radical revisited: A theoretical study of the electronic spectrum.

In this Letter, we report the electronic spectrum of the allyl radical, obtained with multiconfigurational perturbation theory (MS-CASPT2). The assignment of the spectrum is in accordance with experiment to within 0.2 eV. We have computed the complete first Rydberg series and the beginning of the second Rydberg series. A new valence-excited 2B1 state has been found which has hitherto been hidden b

Functional analysis of the classical, alternative, and MBL pathways of the complement system: standardization and validation of a simple ELISA

Primary defence against invading microorganisms depends on a functional innate immune system and the complement system plays a major role in such immunity. Deficiencies in one of the components of the complement system can cause severe and recurrent infections, systemic diseases, such as systemic lupus erythematosus (SLE) and renal disease. Screening for complement deficiencies in the classical or

Multiple Windows for Estimation of Locally Stationary Transients in the Electroencephalogram

In this paper, multiple windows, optimal for locally stationary processes (MW-LSP) are used to estimate the spectrogram of the electroencephalogram (EEG) where we focus on the ability to estimate transient frequency changes. A peak of known frequency was evoked in the EEG spectrum in a predetermined time interval, by using a 9 Hz flickering light. We investigate the multiple windows corresponding

Bose-Einstein correlations in W+W- events at LEP2

Bose-Einstein correlations (BEC) between final state particles in the reaction e(+)e(-) -> W+ W- -> q(1)(q(2)) over barq(3)(q(4)over bar>) over bar) have been studied. Data corresponding to a total integrated luminosity of 550 pb(-1), recorded by the DELPHI detector at centre-of-mass energies ranging from 189 to 209 GeV, were analysed. An indication for inter-W BEC between like-sign particles has

Surface oxides on close-packed surfaces of late transition metals

In recent years, the formation of thin, well-ordered but complex surface oxides on late transition metals has been discovered. The driving force for this line of research has been the strong incentive to increase the partial pressure of oxygen from ultra-high vacuum to conditions more relevant for heterogeneous catalysis. Here we review the present status of the research field. Compared to oxygen