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Europaian Studies

I compare and contrast four cross-disciplinary approaches to the social and natural sciences within the specific context of the tradition of speculation about Europe. As we will see later, I have termed the three conventional social science approaches ‘civilisational’, ‘categorical’, and ‘cultural’ Europe. My innovation is to suggest a fourth approach drawn from the natural sciences — that of ‘co-

The missing tradition of the ES : including Nietzschean relativism and world imagination in extranational studies

Starting from Barry Buzan and Richard Little’s recent assertion in Millennium that ‘international relations has failed as an intellectual project’, I argue that if the study of international political theory is to learn anything from this failure, it is the need for a conversation that encourages heterologue. If such a conversation is to be of any value at all then it needs to escape the binary du

Cross-Ancestry DNA Methylation Marks of Insulin Resistance in Pregnancy : An Integrative Epigenome Wide Association Study

Although there are some epigenome-wide association studies (EWAS) of insulin resistance, most of them did not replicate their findings and are focused in populations of European ancestry limiting the generalizability. In EPIPREG (294 Europeans and 162 South Asians), we conducted an EWAS of insulin resistance in maternal peripheral blood leukocytes, with replication in Born in Bradford (n=879; 430

Religion och politik i hybrida mediemiljöer : En analys av kommentarer till nyheter om Miljöpartiet, Kristdemokraterna och Sverigedemokraterna på Facebook

This dissertation analyses the relationship between religion and politics, situated in hybrid mediaspaces in Sweden. This phenomenon is actualized by contestations over the visibility of religionin public spheres, in combination with changes in the Swedish political debate where conflictsrelated to the left/right scale increasingly come to focus more on value-based issues. Moreover,the effect of d

Global politisk islam? : Muslimska brödraskapet & Islamiska förbundet i Sverige

This thesis puts the question if the Islamic Association of Sweden (Islamiska förbundet I Sverige) can be considered to be a branch of the global, Islamist movement The Muslim Brotherhood. This question is highly controversial in Swedish political and academic conversation. To answer it, an investigation is carried through of the organization, ideology, and practical politics of the two movements.

A simple high-throughput method for automated detection of Drosophila melanogaster light-dependent behaviours

Background: Like most living organisms, the fruit fly Drosophila melanogaster exhibits strong and diverse behavioural reactions to light. Drosophila is a diurnal animal that displays both short- and long-term responses to light, important for, instance, in avoidance and light wavelength preference, regulation of eclosion, courtship, and activity, and provides an important model organism for unders

Clinical and functional characteristics of individuals with alpha-1 antitrypsin deficiency : EARCO international registry

Background: Alpha-1 antitrypsin deficiency (AATD) is a rare disease that is associated with an increased risk of pulmonary emphysema. The European AATD Research Collaboration (EARCO) international registry was founded with the objective of characterising the individuals with AATD and investigating their natural history. Methods: The EARCO registry is an international, observational and prospective

Time-dependence of decontamination efficiency after a fallout of gamma-emitting radionuclides in suburban areas : a theoretical outlook on topsoil removal

Decontamination of urban areas may be necessary in the case of extensive fallout of radioactive material after a nuclear accident, as removal of contaminated soil and vegetation will significantly reduce doses for the residents in an area affected by fallout. Experience from Japan shows that cleanup operations of urban areas may take years despite investment in ample resources. The time delay betw

Copy number signatures for early diagnosis of high-grade serous ovarian carcinoma

BackgroundThe detection of ovarian carcinoma-derived somatic mutations in cervical samples and uterine lavages in several studies since 2013, has brought hope for the development of new biomarkers for early detection. High-grade serous ovarian carcinoma (HGSC) is strongly dominated by copy number alterations (CNAs). These CNAs are the consequence of underlying mutational processes in HGSC. We inte

Current advancements of modelling schizophrenia using patient-derived induced pluripotent stem cells

Schizophrenia (SZ) is a severe psychiatric disorder, with a prevalence of 1–2% world-wide and substantial health- and social care costs. The pathology is influenced by both genetic and environmental factors, however the underlying cause still remains elusive. SZ has symptoms including delusions, hallucinations, confused thoughts, diminished emotional responses, social withdrawal and anhedonia. The

Novel insights regarding the measurement properties of the SCOPA-AUT

Background: The Scale for Outcomes in Parkinson’s disease for Autonomic symptoms (SCOPA-AUT) is an instrument intended to assess overall and domain-specific autonomic symptom burden. In this study the SCOPA-AUT is translated into Swedish and its measurement properties are assessed. Methods: Following translation the SCOPA-AUT was field-tested regarding comprehensibility, relevance, and respondent

Uncovering the true periods of the young sub-Neptunes orbiting TOI-2076

Context. TOI-2076 is a transiting three-planet system of sub-Neptunes orbiting a bright (G = 8.9 mag), young (340 ±80 Myr) K-type star. Although a validated planetary system, the orbits of the two outer planets were unconstrained as only two non-consecutive transits were seen in TESS photometry. This left 11 and 7 possible period aliases for each. Aims. To reveal the true orbits of these two long-

Gendered Self-Views Across 62 Countries: A Test of Competing Models

Social role theory posits that binary gender gaps in agency and communion should be larger in less egalitarian countries, reflecting these countries’ more pronounced sex-based power divisions. Conversely, evolutionary and self-construal theorists suggest that gender gaps in agency and communion should be larger in more egalitarian countries, reflecting the greater autonomy support and flexible sel

Characterization of Patients in the International Severe Asthma Registry with High Steroid Exposure Who Did or Did Not Initiate Biologic Therapy

Background: Many severe asthma patients with high oral corticosteroid exposure (HOCS) often do not initiate biologics despite being eligible. This study aimed to compare the characteristics of severe asthma patients with HOCS who did and did not initiate biologics. Methods: Baseline characteristics of patients with HOCS (long-term maintenance OCS therapy for at least 1 year, or ≥4 courses of stero

Evaluation of evidence supporting NICE recommendations to change people's lifestyle in clinical practice: cross sectional survey

Objectives To assess whether recommendations of individually oriented lifestyle interventions (IOLIs) in guidelines from the National Institute for Health and Care Excellence (NICE) were underpinned by evidence of benefit, and whether harms and opportunity costs were considered.Design Cross sectional survey.Setting UK.Data sources NICE guidelines and supporting evidence.Eligibility criteria All NI

Genotypic and phenotypic spectrum of infantile liver failure due to pathogenic TRMU variants

Purpose: The study aimed to define the genotypic and phenotypic spectrum of reversible acute liver failure (ALF) of infancy resulting from biallelic pathogenic TRMU variants and to determine the role of cysteine supplementation in its treatment. Methods: Individuals with biallelic (likely) pathogenic variants in TRMU were studied through an international retrospective collection of de-identified p