The diffusion of macromolecules, nanoparticles, viruses, and bacteria is essential for targeting hosts or cellular destinations. While these entities can bind to receptors and ligands on host surfaces, the impact of multiple binding sites—referred to as multivalency—on diffusion along strands or surfaces is poorly understood. Through numerical simulations, we have discovered a significant accelera

High-order interactions associated with non-small cell lung cancer (NSCLC) survival may elucidate underlying molecular mechanisms and identify potential therapeutic targets. Our previous work has identified a three-way interaction among pack-year of smoking (the number of packs of cigarettes smoked per day multiplied by the number of years the person has smoked) and two DNA methylation probes (cg0

Background: Local and systemic side effects of glucose remain major limitations of peritoneal dialysis (PD). Glucose transport during PD is thought to occur via inter-endothelial pathways, but recent results show that phloretin, a general blocker of facilitative glucose channels (glucose transporters [GLUTs]), markedly reduced glucose diffusion capacity indicating that some glucose may be transfer

Alchemical free-energy perturbation (FEP) is an accurate and thermodynamically stringent way to estimate relative energies for the binding of small ligands to biological macromolecules. It has repeatedly been pointed out that a single simulation normally stays near the starting point in phase space and therefore underestimates the uncertainty of the results. Therefore, it is better to run an ensem

Nedslag i historien kring Lunds universitets konsistorium/styrelse och dess protokoll.

BACKGROUND: The objective of this study was to evaluate anaesthesia care professionals' perceptions and attitudes regarding the implementation and advancement of digital solutions in perioperative care.METHODS: Anaesthesia personnel working in public Swedish institutions where anaesthesia is administered were invited to respond to an online survey regarding their attitudes towards digitalization i

AimTimeline of atherosclerosis in children with type 1 diabetes is unknown. We aimed to investigate if familial risk of type 1 diabetes is associated with pro-atherosclerotic changes.MethodsYoung first-degree relatives to patients with paediatric type 1 diabetes and sex and age matching controls were enrolled at Skåne University Hospital, Sweden between 2006 and 2015. Conventional lipids, human le

Theoretically there are good reasons to expect social mobility to have an effect on fertility. The problem is how to assess such an effect empirically, as social mobility is a function of both social origin and destination. This paper presents the Diagonal Reference Model (DRM) as a valuable historical method to study social mobility consequences. We use Swedish individual-level longitudinal data