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Prevalence of Atrial Fibrillation and Long-Term Survival of Older Adults; Findings from the SNAC Study

Objective: This study examined the prevalence and long-term survival of atrial fibrillation (AF) in the older population. Methods: Data was recruited from the longitudinal SNAC study from baseline (2001–2004) for up to 10 years. Results: The population comprised 6,904 persons (59% women) (mean age 73.9 years). The prevalence of AF was 4.9% and increased with age. The hazard ratio (HR) for death in

Worst Case Analysis : A Video Analysis Approach to Injury Potential in Traffic

This paper presents a method for evaluating the potential for injury in any traffic scenario involving road user interactions based on trajectory data from a few hours of data of typical traffic conditions. The basic idea was to evaluate to what extent interactions at a location are limited in speed, direction, and whether the interactions happen at a safe speed. Specifically, the method works by

Diagnosis of Alzheimer's disease using plasma biomarkers adjusted to clinical probability

Recently approved anti-amyloid immunotherapies for Alzheimer's disease (AD) require evidence of amyloid-β pathology from positron emission tomography (PET) or cerebrospinal fluid (CSF) before initiating treatment. Blood-based biomarkers promise to reduce the need for PET or CSF testing; however, their interpretation at the individual level and the circumstances requiring confirmatory testing are p

Guidelines for preparation and flow cytometry analysis of human nonlymphoid tissue DC

This article is part of the Dendritic Cell Guidelines article series, which provides a collection of state-of-the-art protocols for the preparation, phenotype analysis by flow cytometry, generation, fluorescence microscopy, and functional characterization of mouse and human dendritic cells (DC) from lymphoid organs, and various nonlymphoid tissues. Within this article, detailed protocols are prese

Hemophilia B Leyden : characteristics and natural history in the International Pediatric Network of Hemophilia Management Registry

Background: A unique form of hemophilia B (HB) is HB Leyden. We evaluated the international Pediatric Network on Hemophilia Management Registry (PedNet) database to explore the natural history of HB Leyden, investigate genotype-phenotype associations, and guide clinical decision-making. Objectives: To assess the association between genetic variants, endogenous factor (F)IX levels over time, treatm

Assessment of 137Cs contamination of combustion products and air pollution during the forest fires in zones of radioactive contamination

The results of the investigation of radiation hazard of forest fires in the radioactive contaminated areas in the article are presented. The activity concentration of long-lived radionuclides in forest fuel materials is shown. Airborne concentration of 137Cs produced by the combustion of forest fuel materials with different contamination density can exceed the permissible activity levels of 137Cs

Advancing personalised care in atrial fibrillation and stroke : The potential impact of AI from prevention to rehabilitation

Atrial fibrillation (AF) is a complex condition caused by various underlying pathophysiological disorders and is the most common heart arrhythmia worldwide, affecting 2 % of the European population. This prevalence increases with age, imposing significant financial, economic, and human burdens. In Europe, stroke is the second leading cause of death and the primary cause of disability, with numbers

Inter- and intrarater reliability of the Eating and Drinking Ability Classification System in Sweden

Purpose: To evaluate inter- and intrarater reliability, of the Eating and Drinking Ability Classification System (EDACS) for children and adults with cerebral palsy (CP) in Sweden. Methods: Four speech and language pathologists rated EDACS from videos of 30 individuals with CP, 3 to 62 years, (mean 21 y, 10 m, SD 18 y, 6 m), six at each level of the Gross Motor Function Classification System (GMFC

Type 2 Diabetes and Change in Total Hip Bone Area and Bone Mineral Density in Swedish Men and Women Older Than 55 Years

Context: In a cross-sectional study, we found an association between type 2 diabetes mellitus (T2DM) and smaller bone area together with greater bone mineral density (BMD) at the total hip.Objective: This work aims to investigate these associations longitudinally, by studying T2DM status (no T2DM n = 1521, incident T2DM n = 119, or prevalent T2DM n = 106) in relation to changes in total hip bone a

A core outcome set for best care for the dying person : Results of an international Delphi study and consensus meeting

Background: Outcome measurement is essential to progress clinical practice and improve patient care. Aim: To develop a Core Outcome Set for best care for the dying person. Design: We followed the Core Outcome Measures in Effectiveness Trials (COMET) Initiative guidelines, which involved identifying potential outcomes via a systematic literature review (n = 619 papers) and from participants in the

Cybersecurity and smart tourist destinations resilience

Empirical research on the resilience of smart tourist destinations (STDs) to cybersecurity threats is scarce. The current research aims to address this gap by exploring cybersecurity risks within STDs and their resilience to withstand cyber threats. Employing a qualitative approach, we conducted 15 semi-structured interviews with cybersecurity experts and stakeholders in Dubai’s tourism and hospit

Premisser för en höjd repressionsnivå och nyanserad straffmätning

Frågorna hur den allmänna repressionsnivån och enskilda straff ska se ut placeras ofta antingen hos lagstiftare eller domare. Men för att på allvar kunna diskutera frågorna och vad som är önskvärt behövs gediget underlag och en öppenhet för frågornas komplexitet och olika infallsvinklar.

Regression to the mean for physical function and quality of life in clinical trials for symptomatic knee osteoarthritis

Objective: To estimate the size of regression to the mean (RTM) for common patient-reported outcomes in trials for knee osteoarthritis (OA). Design: Longitudinal cohort study; we included participants of the Osteoarthritis Initiative who fulfilled typical inclusion criteria for enrolment in a trial. These included: age 40–79 years, symptomatic knee OA, Kellgren-Lawrence grade 2–3, use of pain medi

Using age-ratios to investigate the status of two Siberian Phylloscopus species in Europe

Distinguishing between vagrancy and regular migration has proved to be challenging as vagrants may, in theory, act as pioneers in the establishment of new migration routes. Because migratory songbirds tend to follow the same orientation and migration route throughout their lives, age assessment can help to distinguish individuals which have already used a route (i.e. adults) from those using it fo