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Performance of a Methanol-Fueled Direct-Injection Compression-Ignition Heavy-Duty Engine under Low-Temperature Combustion Conditions

Low-temperature combustion (LTC) concepts, such as homogeneous charge compression ignition (HCCI) and partially premixed combustion (PPC), aim to reduce in-cylinder temperatures in internal combustion engines, thereby lowering emissions of nitrogen oxides (NOx) and soot. These LTC concepts are particularly attractive for decarbonizing conventional diesel engines using renewable fuels such as metha

Okinawa-Based Nordic Diet Decreases Plasma Glial Fibrillary Acidic Protein Levels in Type 2 Diabetes Patients

Elevated levels of glial fibrillary acidic protein (GFAP) in plasma reflect neuroinflammation and are linked to cognitive decline. Preclinical studies show that dietary change can attenuate astrocyte reactivity and neuroinflammation. In the current study, we investigate if the Okinawa-based Nordic (O-BN) diet alters plasma GFAP levels in patients with Type 2 Diabetes (T2D), a metabolic disorder as

Work-restricting musculoskeletal pain after bariatric surgery or usual obesity care in the Swedish Obese Subjects study

Objective: The objective of this study was to study the recovery from, and incidence of, work-restricting musculoskeletal pain after bariatric surgery compared with usual obesity care. Methods: Pain in different body regions was monitored using questionnaires in the nonrandomized, prospective, controlled Swedish Obese Subjects (SOS) study, which included 2007 participants treated with bariatric su

Aquaporin-3a Dysfunction Impairs Osmoadaptation in Post-Activated Marine Fish Spermatozoa

Spermatozoon volume regulation is an essential determinant of male fertility competence in mammals and oviparous fishes. In mammals, aquaporin water channels (AQP3, -7 and -8) have been suggested to play a role in spermatozoon cell volume regulatory responses in the hypotonic female oviduct. In contrast, the ejaculated spermatozoa of marine teleosts, such as the gilthead seabream (Sparus aurata),

Type 1 diabetes, celiac disease, and autoimmune thyroiditis autoantibodies in population-based type 2 diabetes patients

Aims: The study aims were to determine autoantibodies associated with type 1 diabetes (T1D), celiac disease (CD) and autoimmune thyroid disease (AITD) in individuals living with type 2 diabetes (T2D) compared to T1D and matched controls. Methods: Individuals with T1D and T2D were randomly identified in health-care registers. Blood was collected through home-capillary sampling and autoantibodies as

Sugar signaling modulates SHOOT MERISTEMLESS expression and meristem function in Arabidopsis

In plants, development of all above-ground tissues relies on the shoot apical meristem (SAM) which balances cell proliferation and differentiation to allow life-long growth. To maximize fitness and survival, meristem activity is adjusted to the prevailing conditions through a poorly understood integration of developmental signals with environmental and nutritional information. Here, we show that s

Overview : Global change effects on terrestrial biogeochemistry at the plant-soil interface

"Global change"significantly alters organic matter and element cycling, but many of the underlying processes and consequences remain poorly understood. The interface of plants and soil plays a central role, coupling the atmosphere, hydrosphere, biosphere and lithosphere and integrating biological and geochemical processes. The contributions to this special issue address questions on both biotic an

Development of a three-dimensional scoring model for the assessment of continuous glucose monitoring data in type 1 diabetes

Introduction Despite the improvements in diabetes management by continuous glucose monitoring (CGM) it is difficult to capture the complexity of CGM data in one metric. We aimed to develop a clinically relevant multidimensional scoring model with the capacity to identify the most alarming CGM episodes and/or patients from a large cohort. Research design and methods Retrospective CGM data from 2017

The Gut Microbiota and Diabetes : Research, Translation, and Clinical Applications—2023 Diabetes, Diabetes Care, and Diabetologia Expert Forum

This article summarizes the state of the science on the role of the gut microbiota (GM) in diabetes from a recent international expert forum organized by Diabetes, Diabetes Care, and Diabetologia, which was held at the European Association for the Study of Diabetes 2023 Annual Meeting in Hamburg, Germany. Forum participants included clinicians and basic scientists who are leading investigators in

Clinical cell-surface targets in metastatic and primary solid cancers

Therapies against cell-surface targets (CSTs) represent an emerging treatment class in solid malignancies. However, high-throughput investigations of CST expression across cancer types have been reliant on data sets of mostly primary tumors, despite therapeutic use most commonly in metastatic disease. We identified a total of 818 clinical trials of CST therapies with 78 CSTs. We assembled a data s

Observations of Igneous Subsurface Stratigraphy during the Jezero Crater Floor Rapid Traverse from the RIMFAX Ground-penetrating Radar

Perseverance traversed the eastern, northern, and western margins of the Séítah formation inlier on the rover’s western fan front approach. Mapping the stratigraphy and extent of the Máaz and Séítah formations is key to understanding the depositional history and timing of crater floor resurfacing events. Perseverance's rapid progress across the Jezero crater floor between the Octavia E. Butler lan

Self-assessed performance-based function test versus patient-reported outcome measures for knee and hip osteoarthritis

BACKGROUND: Physical function constitutes a key component of outcome assessment for almost all osteoarthritis interventions. The aim was to compare physical function measured using a self-assessed performance-based test versus self-reported function using questionnaires among individuals with knee or hip osteoarthritis (OA) participating in a digital exercise and education therapy.METHODS: We anal

Monolingual comparative normativity in bilingualism research is out of “control”: Arguments and alternatives

Herein, we contextualize, problematize, and offer some insights for moving beyond the problem of monolingual comparative normativity in (psycho) linguistic research on bilingualism. We argue that, in the vast majority of cases, juxtaposing (functional) monolinguals to bilinguals fails to offer what the comparison is supposedly intended to do: meet the standards of empirical control in line with th

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We investigate the situation of heritage speakers in Italian language classes in a federal state in Germany, taking three perspectives: (i) the micro-perspective of heritage speakers, mostly fluent in Italian but often bidialectal, (ii) the meso-perspective of the teachers who must interact adequately with them, (iii) the macro-perspective of the education policies that determine the curriculum. T

Testing Potential Transfer Effects in Heritage and Adult L2 Bilinguals Acquiring a Mini Grammar as an Additional Language: An ERP Approach

Models on L3/Ln acquisition differ with respect to how they envisage degree (holisticvs. selective transfer of the L1, L2 or both) and/or timing (initial stages vs. development) of howthe influence of source languages unfolds. This study uses EEG/ERPs to examine these models,bringing together two types of bilinguals: heritage speakers (HSs) (Italian-German, n = 15) comparedto adult L2 learners (L1

Structural and phonological cues for gender assignment in monolingual and bilingual children acquiring German. : Experiments with real and nonce words

We investigate the acquisition of grammatical gender marking in German by monolingual children as well as German-Russian bilingual children who grow up in Germany as heritage speakers of Russian. We ask to what extent monolingual and bilingual children use phonological and/or structural cues to assign nominal gender, and to what extent they rely on lexical knowledge. To this end, we designed three

Foreign Accent in Pre- and Primary School Heritage Bilinguals

Previous research has shown that the two languages of early bilingual children can influence each other, depending on the linguistic property, while adult bilinguals predominantly show influence from the majority language to the minority (heritage) language. While this observed shift in influence patterns is probably related to a shift in dominance between early childhood and adulthood, there is l