Abstract: Background/Objectives: Vitamin K-dependent proteins (VKDPs) all commonlypossess specially modified γ-carboxyglutamic acid residues created in a vitaminK-dependent manner. Several liver-derived coagulation factors are well characterisedVKDPs. However, much less is known about extrahepatic VKDPs, which are more diversein their molecular structures and functions, and some of which have beenBackground/Objectives: Vitamin K-dependent proteins (VKDPs) all commonly possess specially modified γ-carboxyglutamic acid residues created in a vitamin K-dependent manner. Several liver-derived coagulation factors are well characterised VKDPs. However, much less is known about extrahepatic VKDPs, which are more diverse in their molecular structures and functions, and some of which have been impli

Working from anywhere, often associated with digital nomadism, is a growing trend that blurs the boundaries between work and leisure, with individuals choosing to work from tourist destinations. The phenomenon has caught the attention of academics, who mainly focus on the lifestyle aspects of digital nomadism. However, destination management organizations, as well as the tourism and hospitality in

The main section of this chapter describes vowel harmony (VH) in Khalkha Mongolian, which has both tongue-root harmony and rounding harmony. The vowels are divided into two classes, retracted tongue root (RTR), a, ?, ?, and advanced tongue root (ATR), e, o, u, while i is neutral. There is rich inflectional and derivational morphology based on suffixes, whose vowels alternate with the harmony class

Whether developed or less developed, all countries need skilled mental labor (SML) to use technologies effectively and to attain economic growth and development. Without appropriate SML, no country can make the best use of its firms and institutions. Time and investment are required for an individual to become a skilled mental laborer, but these are not sufficient. The training must be at a level

Body dysmorphic disorder (BDD) is an obsessive–compulsive disorder-related psychiatric condition characterized by an intense preoccupation with perceived physical flaws that are not observable by others. BDD affects ~2% of the adult population but is underdiagnosed, partly owing to limited clinician awareness, and undertreated, partly due to limited access to treatment. Research on the aetiology o

Background: Supplier involvement in product development has proven beneficial for companies and is a phenomenon researched in various domains. The definitions of supplier involvement represent points of origin and dimensions addressed in research. Still, there is no overview of these definitions and dimensions. This study reviews current definitions of the phenomenon of supplier involvement in pro

Background: The Abdominal Compartment Society (WSACS) established consensus definitions and recommendations for the management of intra-abdominal hypertension (IAH) and abdominal compartment syndrome (ACS) in 2006, and they were last updated in 2013. The WSACS conducted an international survey between 2022 and 2023 to seek the agreement of healthcare practitioners (HCPs) worldwide on current and n

Aims: The purpose of this study was to address the need to improve opportunities for patient participation in their health and health services. This paper reports if and how patients' preferences matched their experiences of participation in treatment for hypertension in primary healthcare and what factors were linked with having had opportunities for participation that matched one's preferences.

Aims: Among patients with myocardial infarction (MI) with preserved left ventricular ejection fraction (LVEF), the REDUCE-AMI trial did not demonstrate a benefit of beta-blocker vs. no beta-blocker treatment on all-cause mortality and recurrent myocardial infarction. The aim of this pre-specified sub-study was to investigate effects of beta-blockers on self-reported symptoms of anxiety and depress

Modern hydrological modeling frequently incorporates global remote sensing or reanalysis products for multivariate calibration. Although these datasets significantly contribute to model accuracy, the inherent uncertainties in the datasets and multivariate calibration present challenges in the modeling process. To address this issue, this study introduces an adaptive, process-wise fitting framework

The hemodynamic definitions of pulmonary hypertension consider resistive loading (pulmonary vascular resistance [PVR]), but there are increasing evidence that pulsatile loading (pulmonary artery compliance [PAC]) has functional and prognostic importance. The aims of the present study on patients with left heart disease, were to evaluate a novel echocardiographic right ventricular (RV) afterload sc

In their most extreme form, sex chromosomes exhibit a complete lack of genetic recombination along much of their length in the heterogametic sex. Some recent models explain the evolution of such suppressed recombination by the "sheltering"of deleterious mutations by chromosomal inversions that prevent recombination around a polymorphic locus controlling sex. This sheltering hypothesis is based on

Background: In breast cancer, several gene expression assays have been developed to provide a more personalised treatment. This study focuses on the prediction of two molecular proliferation signatures: an 11-gene proliferation score and the MKI67 proliferation marker gene. The aim was to assess whether these could be predicted from digital whole slide images (WSIs) using deep learning models. Met

The Schmidt number represents the genuine entanglement dimension of a bipartite quantum state. We derive simple criteria for the Schmidt number of a density matrix in arbitrary local dimensions, given that certain symmetric measurements exist. They are based on the trace norm of correlations obtained from seminal families of quantum measurements, specifically symmetric informationally complete mea

Denna avhandling är en sammanläggningsavhandling som utforskar möjligheterna att producera humanistisk samhällsvetenskap om "terrorism" och jihadism genom att använda queerteori, cripteori och affektteori. Den analyserar både jihadistiska gruppmedlemmar och sättet att producera kunskap om dessa ämnen. Genom att utmana reduktionistiska narrativ som framställer dessa individer som avvikande eller moThis dissertation is an article compilation thesis that explores the possibility of producing humanistic social science in general, using the case of conducting research on jihadist group members within the ‘War on Terror’ context. Empirically, the study employs first-hand interviews of jihadist group members in France. It finds that employing queer theory, crip theory, and affect theory to analyz

Objective Systemic sclerosis Impact of Disease (ScleroID) is the first comprehensive patient-reported outcome measure (PROM) specifically developed for systemic sclerosis (SSc). We investigated the performance of ScleroID in patients with diffuse cutaneous SSc (dcSSc), as a prerequisite for its use in randomised controlled trials (RCTs) testing potentially disease-modifying drugs. Methods All pati

Infants at elevated likelihood for or later diagnosed with autism typically have smaller vocabularies than their peers, as shown by the Mullen Scales of Early Learning (MSEL) and the MacArthur-Bates Communicative Developmental Inventory (CDI). However, the extent to which MSEL and CDI scores align remains unclear, especially across clinical and non-clinical populations. This study examined whether

Bioresorbable photonic implants are emerging as potential material choice for interstitial theranostic and monitoring applications. They gradually dissolve within the physiological environment in a clinically relevant period, eliminating the need for extraction surgeries. In the present study, we tested the suitability of in-house fabricated bioresorbable optical fibres based on calcium phosphate

With the current state of knowledge regarding disorders of facial bone development, including anodontia, the development of a suitable animal model for preclinical studies is essential. The agenesis of dental buds occurs in about 25% of the human population. Prospects for treatment include the use of growth factors, stem cells, and bioengineering. This study aimed to investigate the influence of a