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Intracellular K+ Determination With a Potentiometric Microelectrode Based on ZnO Nanowires

The fabrication and application of an intracellular K+-selective microelectrode is demonstrated. ZnO nanowires with a diameter of 100-180 nm and a length of approximately 1.5. m are grown on a borosilicate glass microcapillary. The ZnO nanowires were coated by a K+-ionophore-containing membrane. The K+-selective microelectrode exhibited a K+-dependent potentiometric response versus an Ag/AgCl refe

A Dynamic Modelling Framework for Control-based Computing System Design

This manuscript proposes a novel viewpoint on computing systems' modelling. The classical approach is to consider fully functional systems and model them, aiming at closing some external loops to optimise their behaviour. On the contrary, we only model strictly physical phenomena, and realise the rest of the system as a set of controllers. Such an approach permits rigorous assessment of the obtain

Low 8-oxo-7,8-dihydro-2'-deoxyguanosine levels and influence of genetic background in an Andean population exposed to high levels of arsenic.

BACKGROUND: Arsenic (As) causes oxidative stress through generation of reactive oxygen species. 8-Oxo-7,8-dihydro-2'-deoxyguanosine (8-oxodG), a sensitive marker of oxidative DNA damage, has been associated with As exposure in some studies, but not in others, possibly due to population-specific genetic factors. OBJECTIVES: To evaluate the association between As and 8-oxodG in urine in a population

Breast feeding, but not use of oral contraceptives, is associated with a reduced risk of rheumatoid arthritis

Objective: To determine whether breast feeding or the use of oral contraceptives (OCs) affects the future risk of rheumatoid arthritis ( RA) in a community-based prospective cohort. Methods: A community-based health survey (18 326 women) was linked to regional and national registers, and incident cases of RA were identified. All women with a diagnosis of RA after inclusion in the health survey (n

Cerebrospinal Fluid (CSF) 25-Hydroxyvitamin D Concentration and CSF Acetylcholinesterase Activity Are Reduced in Patients with Alzheimer's Disease

Background: Little is known of vitamin D concentration in cerebrospinal fluid (CSF) in Alzheimer's disease (AD) and its relation with CSF acetylcholinesterase (AChE) activity, a marker of cholinergic function. Methods: A cross-sectional study of 52 consecutive patients under primary evaluation of cognitive impairment and 17 healthy controls. The patients had AD dementia or mild cognitive impairmen

CRIM1 is localized to the podocyte filtration slit diaphragm of the adult human kidney

Background. CRIM1 is a plasma membrane bound protein containing six cysteine-rich repeats (CRR). Through these, CRIM1 has been shown to interact with a subgroup of the TGF-β superfamily, the bone morphogenic proteins (BMP) isoforms 2, 4 and 7. The probable action is to modulate the signalling properties of these factors. CRIM1 has also been shown to regulate the release of VEGFA by podocytes durin

The Production of Bergen

The production of space contains an antagonism between a use-value relation and an exchange-value relation. In this paper these categories are used to analyse two empirical cases from Bergen, Norway. The first case concerns a public debate in 2005, about whether Clear Channel should be allowed to install advertising boards in the city. The second case concerns a debate in 2007, about whether Berge

Spatial soil loss risk and reservoir siltation in semi-arid Tunisia

Soil erosion vulnerability and extreme rainfall characteristics over the Mediterranean semi-arid region of Tunisia are crucial input for estimation of siltation rate in artificial reservoirs. A comprehensive high-resolution database on erosive rainfall, together with siltation records for 28 small reservoirs, were analysed for this region, the Tunisian Dorsal (the easternmost part of the Atlas Mou

Soil bacterial growth and nutrient limitation along a chronosequence from a glacier forefield

Resource availability and limiting factors for bacterial growth during early stages of soil development (8-138 years) were studied along a chronosequence from the glacial forefield of the Damma glacier in the Swiss Alps. We determined bacterial growth (leucine incorporation) and we investigated which resource (C, N or P) limited bacterial growth in soils formed by the retreating glacier. The latte

Multidimensional Cramér-Rao Lower Bound for Non-uniformly Sampled NMR Signals

In this work, we extend recent results on the Cramé r-Rao lower bound for multidimensional non-uniformly sampled Nuclear Magnetic Resonance (NMR) signals. The used signal model is more general than earlier models, allowing for the typically present variance differences between the direct and the dif- ferent indirect sampling dimensions. The presented bound is verified with earlier presented 1-and

Traffic updating mechanisms for stochastic lattice-free dynamics

We introduce a novel lattice-free stochastic process which models vehicular traffic at the microscopic level. Vehicles are allowed to advance freely within their lane or change lanes without the limitation of lattice cells. Vehicles move under the influence of modified yet classical stochastic spin-flip and spin-exchange Arrhenius dynamic potentials. A modification of the well-known kinetic Monte

Comparison of ultrasonography with Doppler and MRI for assessment of disease activity in juvenile idiopathic arthritis: a pilot study

Background: In juvenile idiopathic arthritis (JIA), the trend towards early therapeutic intervention and the development of new highly effective treatments have increased the need for sensitive and specific imaging. Numerous studies have demonstrated the important role of MRI and US in adult rheumatology. However, investigations of imaging in JIA are rare, and no previous study has been comparing

Prosodic boundaries and discourse structure in Kammu

The main function of sentence intonation in Kammu is to mark prosodic boundaries. There is no additional tonal marking of focus. It is of particular in- terest that the underlying intonation system is the same for both tonal (Northern Kammu) and non-tonal (Eastern Kammu) dialects. Prosodic boundaries in Kammu have three func- tions: they mark prosodic phrases, focus and speaker engagement. In this