Objective To investigate the association between vaccinations in adults and the risk of developing rheumatoid arthritis (RA). Methods Data from the Swedish population-based Epidemiological Investigation of RA case-control study encompassing 1998 incident cases of RA aged 18-70 years and 2252 randomly selected controls matched for age, sex and residency were analysed. Those vaccinated within 5 year

Primary Sjogren's syndrome (SS) is a systemic autoimmune inflammatory disease characterized by focal lymphocytic infiltrates in the lachrymal and salivary glands and autoantibodies against the SSA/Ro and SSB/La antigens. Experimental studies have shown an activation of NF-B in primary SS. NF-B activation results in inflammation and autoimmunity and is regulated by inhibitory and activating protein

Recension av Olle Östlind, Essäer om Henry B. Goodwin.

Popular Abstract in Swedish Om blodkärlen i ögat läcker eller om blodflödet stoppas får inte näthinnan den mängd syre och näring som den behöver. Detta tillstånd kallas ischemi och kan leda till att näthinnans celler skadas. Näthinnan ligger längst bak i ögat och fungerar som filmen i en kamera. Stavar och tappar registrerar ljus och signalen går via nerver till syncentra i hjärnan. Blodkärl (artäIdentification of the intracellular signal transduction pathways activated in retinal ischaemia may be important in revealing novel pharmacological targets. The retinal blood vessels are key organs in circulatory failure, and in this work the retinal vasculature was therefore examined separately from the neuroretina. The porcine eye has a typical primate-like architecture and is similar to the hum

The thesis covers different topics related to model predictive control (MPC) and particularly distributed model predictive control (DMPC). One topic of the thesis is gradient-based optimization algorithms for solving the optimization problem arising in DMPC in a distributed manner. The underlying idea is to solve the optimization problem in distributed fashion using dual decomposition, which is a

In North Sámi, certain verbal derivations can be expressed as a change of theme vowel. An investigation of these derivations leads to the conclusion that spanning, i.e. one vocabulary item spelling out two or more terminal nodes, should be included in the toolbox of Distributed Morphology. It follows that com¬petition between vocabulary items is resolved according to the Principle of Maximal Expre

Abstract: In the interface, between implant and bone or between the cement and bone, there will develop some amount of fibrous tissue. The synovial fluid, the synovium, the cartilage and the subchondral bone from the non-replaced knee compartment that had been exposed to wear particles were studied by histological analyses. These analyses showed polyethylene wear particles in all tissues except t

Common variants at only two loci, FTO and MC4R, have been reproducibly associated with body mass index (BMI) in humans. To identify additional loci, we conducted meta-analysis of 15 genome-wide association studies for BMI (n > 32,000) and followed up top signals in 14 additional cohorts (n > 59,000). We strongly confirm FTO and MC4R and identify six additional loci (P < 5 x 10(-8)): TMEM18, KCTD15

HAMLET (Human Alpha-lactalbumin Made LEthal to Tumor cells) is a complex of partially unfolded human alpha-lactalbumin and oleic acid that kills many different types of tumor cells and shows therapeutic efficacy in animal models and clinical studies. This thesis aims to (1) elucidate the structure of HAMLET and the exposure of biologically active domains, (2) define the contribution of lipids to t

I det moderna samhället är en välplanerad infrastruktur med fungerande transporter och pendling en självklarhet. Transportsystemet har inverkan på fysisk och social miljö och det finns ett stort behov av att minska de negativa effekterna. Förutom tillgänglighet och minskad miljöpåverkan betonas ofta vikten av kostnadseffektivitet. Denna rapport beskriver ett verktyg framtaget inom ramen för HASTA

Protein S deficiency is a dominantly inherited disorder that results from mutations in the PROS] gene. Previous sequencing of the gene failed to detect mutations in eight out of 18 investigated Swedish families, whereas segregation analyses detected large deletions in three out of the eight families. The present study investigates more thoroughly for the presence of deletions but also for other ty

We herein report the reversible formation of a planar lamellar phase as an intermediate structure in a vesicle-micelle transition induced by temperature, for a salt-free catanionic surfactant-water system. Turbidity, small-angle neutron scattering, dynamic light scattering and microscopy data altogether demonstrate that the vesicles formed by hexadecyltrimethylammonium octylsulfonate (TA(16)So(8))

High-density lipoprotein (HDL) has anti-atherogenic properties and the plasma level of HDL cholesterol correlates inversely with the risk of coronary artery disease. The atheroprotective functions of HDL can be explained by its function in the reverse cholesterol transport. Blood coagulation is activated in response to tissue damage and involves a series of enzymatic protein complexes that assembl

Sustainable development represents a commitment to advancing human well-being, with the added constraint that this development needs to take place within the ecological limits of the biosphere. Progress in both these dimensions of sustainable development can be assessed: we use the UN Human Development Index (HDI) as an indicator of development and the Ecological Footprint as an indicator of human

This dissertation examines how young people with Kurdish backgrounds form their identity in Sweden with regards to processes of inclusion and exclusion. It also sheds light on the ways these young people deal with ethnic discrimination and racism. Further, the study outlines the importance of these social processes for the discipline of social work and the ways social workers can work with disadva