Appropriate Wnt morphogen secretion is required to control animal development and homeostasis. Although correct Wnt globular structure is essential for secretion, proteins that directly mediate Wnt folding and maturation remain uncharacterized. Here, we report that protein disulfide isomerase-1 (PDI-1), a protein-folding catalyst and chaperone, controls secretion of the Caenorhabditis elegans Wnt

The Caenorhabditis elegans (C. elegans) germline is used to study several biologically important processes including stem cell development, apoptosis, and chromosome dynamics. While the germline is an excellent model, the analysis is often two dimensional due to the time and labor required for three-dimensional analysis. Major readouts in such studies are the number/position of nuclei and protein

The Caenorhabditis elegans germline is widely used as a model to study stem cell development, chromosome dynamics and apoptosis. Major readouts of germline phenotypes such as cell counting and protein expression profiling are routinely analyzed manually and in a two-dimensional manner. The major disadvantages of the existing approaches are 1) they are time-consuming and laborious and 2) there is a

Burr formation is a problematic aspect in the machining of ductile metals. Understanding the formation mechanism and being able to model the plastic workpiece behavior during tool exits is key to burr minimization. A 3D finite element model is used to simulate burr formation during the exit phase of intermittent turning of AISI 4140, using a nose radiused insert. The model is validated by experime

Functional interplay between tumour cells and their neoplastic extracellular matrix plays a decisive role in malignant progression of carcinomas. Here we provide a comprehensive data set of the human HNSCC-associated fibroblast matrisome. Although much attention has been paid to the deposit of collagen, we identify oncofetal fibronectin (FN) as a major and obligate component of the matrix assemble

To locate objects in the world, speakers typically use two linked indicating strategies: spoken expressions like 'here' or 'there,' and simultaneous head and hand movements to point to the object. A growing body of research asks how these strategies draw attention to physical space, and what motivates speakers to use the strategies in isolation or in combination.The REaCHeS project examines indica

Communication practitioners still struggle to increase their status and legitimacy, and the value of their work is often questioned. The general perception of the occupation is often related to the idea that communication practitioners manipulate with misleading information and primarily are involved in superficial activities such as image and reputation building. In attempting to defend themselve

Emerging data indicates SGRT could improve safety and quality by preventing errors in its capacity as an independent system in the treatment room. The aim of this work is to investigate the utility of SGRT in the context of safety and quality. Three incident learning systems (ILS) were reviewed to categorize and quantify errors that could have been prevented with SGRT: SAFRON (International Atomic

Communicative coworkership is an area with great potential for both organizations and communicators. Communicative coworkership is also an area where there is a clear link between the core operation and the communication of the organization. It is fairly easy to demonstrate the value of communicative coworkership for an organisation, for example in terms of crisis aversion, innovation, listening,

The increase in both the use of open-source software (OSS) and the number of new vulnerabilities reported in this software constitutes an increased threat to businesses, people, and our society. To mitigate this threat, vulnerability information must be efficiently handled in organizations. In addition, where e.g., IoT devices are integrated into systems, such information must be disseminated from

Recension av Henrik Brissman, Framtidens historia.