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Monoglyceride Lipase Deficiency Is Associated with Altered Thrombogenesis in Mice

Monoglyceride lipase (MGL) hydrolyzes monoacylglycerols (MG) to glycerol and one fatty acid. Among the various MG species, MGL also degrades 2-arachidonoylglycerol, the most abundant endocannabinoid and potent activator of the cannabinoid receptors 1 and 2. We investigated the consequences of MGL deficiency on platelet function using systemic (Mgl-/-) and platelet-specific Mgl-deficient (platMgl-/

Ignorance and the regulation of artificial intelligence

Much has been written about the risks posed by artificial intelligence (AI). This article is interested not only in what is known about these risks, but what remains unknown and how that unknowing is and should be approached. By reviewing and expanding on the scientific literature, it explores how social knowledge contributes to the understanding of AI and its regulatory challenges. The analysis i

Pluralism, paralysis, practice: making environmental knowledge usable

In recent years, the global environmental science-policy interface has come to include a greater variety of knowledge. Social scientists have joined natural scientists at the policy table, and Indigenous and local knowledge is being taken ever more seriously. But this pluralisation raises political, normative, and epistemic challenges for environmental expert organisations, including with respect

Treatment of Mouse Infants with Amoxicillin, but Not the Human Milk-Derived Antimicrobial HAMLET, Impairs Lung Th17 Responses

Emerging evidence suggests differential effects of therapeutic antibiotics on infant T cell responses to pathogens. In this study, we explored the impact of the treatment of mouse infants with amoxicillin and the human milk-derived antimicrobial HAMLET (human alpha-lactalbumin made lethal to tumor cells) on T cell responses to Streptococcus pneumoniae. Lung cells and splenocytes were isolated fro

Contraction of human brain vascular pericytes in response to islet amyloid polypeptide is reversed by pramlintide

The islet amyloid polypeptide (IAPP), a pancreas-produced peptide, has beneficial functions in its monomeric form. However, IAPP aggregates, related to type 2 diabetes mellitus (T2DM), are toxic not only for the pancreas, but also for the brain. In the latter, IAPP is often found in vessels, where it is highly toxic for pericytes, mural cells that have contractile properties and regulate capillary

Goda råd för att minska klimat- och luftpåverkan - hur fungerar informationsinsatser riktade till jordbruket?

Jordbruket är en av de sektorer i samhället som har störst klimatpåverkan genom utsläppet av växthusgaser och användningen av mark. Samtidigt är jordbruket den huvudsakliga källan till utsläppet av ammoniak i Sverige. Ammoniak kan i sin tur bilda hälsovådliga partiklar. Att minska klimatpåverkan och luftutsläpp kan därför vara av stor betydelse för att nå uppsatta miljömål. Till skillnad från andr

An examination of distress tolerance, anxiety sensitivity, and intolerance of uncertainty in adults in routine psychiatric care

AimA person's ability to tolerate negative emotional states (Distress Tolerance - DT), uncertainty in their everyday lives (Intolerance of Uncertainty - IU), and a tendency to appraise their own feelings of anxiety as harmful (Anxiety Sensitivity - AS) have all been identified as vulnerability factors for anxiety and depressive disorders. However, the relationship between these variables and broad

Implementing Electronic Management of Assessment and Feedback in Higher Education

All assessments are events within a process that has the goal of making decisions about instruction, learning, curriculum, students, institutions, and consequences. Three underlying disciplines (i.e., psychometrics, psychology, and sociology) inform the evaluation of assessments. Error is ubiquitous in the selection of tasks that constitute an assessment, the administration, marking, reporting, an

Working towards the inclusive campus : A partnership project with students of colour in a university reform initiative

Much has been written about valuing the student voice in UK higher education. The discussion runs alongside an increasing focus from university leadership on improving students’ experiences, and development of the ways in which the student voice is captured, considered, and acted upon. These techniques are central to understanding and developing student engagement (Brooman et al. 2014; Cook-Sather

The role of internal and external moderation for assuring academic standards

Drawing on the review of quality assurance policies in higher education already set out of the introduction, this chapter explores the impact of national quality assurance processes adopted to aid consistency in the judgement of academic standards in UK higher education. Specifically, it will examine the ways in which the processes adopted to support marking and to moderate marks, known collective

The greater/public good and research impact

“Those who can make you believe absurdities can make you commit atrocities” is a famous aphorism commonly attributed to Voltaire. The choice to publish under an alias for François-Marie Arouet, reveals that there was some sort of awareness of the relationship between power, knowledge, truth and people’s tyrannical tendencies on his part. What our dear enlightened friend could most likely not fores