Streams of stars from captured dwarf galaxies and dissolved globular clusters are identifiable through the similarity of their orbital parameters, a fact that remains true long after the streams have dispersed spatially. We calculate the integrals of motion for 31 234 stars, to a distance of 4 kpc from the Sun, which have full and accurate 6D phase space positions in the Gaia DR2 catalogue. We the

RATIONALE: The alarmin S100A9 has been identified as a potential therapeutic target in myocardial infarction. Short-term S100A9 blockade during the inflammatory phase post-myocardial infarction inhibits systemic and cardiac inflammation and improves cardiac function long term. OBJECTIVE: To evaluate the impact of S100A9 blockade on postischemic cardiac repair. METHODS AND RESULTS: We assessed card

As the hardest tissue formed by vertebrates, enamel represents nature's engineering masterpiece with complex organizations of fibrous apatite crystals at the nanometer scale. Supramolecular assemblies of enamel matrix proteins (EMPs) play a key role as the structural scaffolds for regulating mineral morphology during enamel development. However, to achieve maximum tissue hardness, most organic con

Oxidative stress is associated with many renal disorders, both acute and chronic, and has also been described to contribute to the disease progression. Therefore, oxidative stress is a potential therapeutic target. The human antioxidant α1-microglobulin (A1M) is a plasma and tissue protein with heme-binding, radical-scavenging and reductase activities. A1M can be internalized by cells, localized t

A method for the electrochemical synthesis of palladium nanowires, using porous alumina templates with diameters of 25 nm and 40 nm, is presented. Through an electrochemical barrier layer thinning step, pulsed electrodeposition can take place directly into the anodized aluminum; without need for extra removal, pore opening, and metal contact coating steps. A digital oscilloscope is used to record

This article argues that the entanglements of a growing global demand for construction material and neoliberal resource governance result in an incremental and piecemeal form of dispossession. While mining in Colombia has been broadly researched, little has been said about sand extraction and the challenges small-scale artisanal miners face when trying to formalise their activities. This article s

In order to improve the active regenerative cooling performance of a scramjet using supercritical n-decane, a new type of cooling channel, the double-layer channel, is proposed. Based on reliable numerical simulations, temperature profiles, fluid flow track, vortex structure and buoyancy force distribution of three cases are presented, respectively. It is found that the heat transfer performance o

Objective: The present study addresses the problem of estimating the respiratory rate from the mor- phological ECG variations in the presence of atrial fibrilla- tory waves (f-waves). The significance of performing f-wave suppression before respiratory rate estimation is investi- gated. Methods: The performance of a novel approach to ECG-derived respiration, named “slope range” (SR) and de- signed

How did industrialisation affect land use and residential patterns in cities of the nineteenth century? We use census data and GIS mapping techniques to analyse class segregation and changes to the spatial structure using the case of Uppsala, Sweden between 1880 and 1900. We find that there was a clear concentration of business activity in the central district and in proximity to the transportatio

Background: Chronic nodular prurigo (CNPG) is a condition characterized by chronic itch, a prolonged scratching behaviour and the presence of pruriginous nodules. A comprehensive understanding of this condition, especially regarding its clinical characteristics and impact on quality of life is still lacking. Objectives: Aim of this pan-European multicentre cross-sectional study was to establish th

Background: The emergence of highly active novel agents has led some to question the role of autologous haematopoietic stem-cell transplantation (HSCT) and subsequent consolidation therapy in newly diagnosed multiple myeloma. We therefore compared autologous HSCT with bortezomib–melphalan–prednisone (VMP) as intensification therapy, and bortezomib–lenalidomide–dexamethasone (VRD) consolidation the

The superfluid tunneling model is applied to the calculation of ground-state–to–ground-state α decay in the even-even neutron-deficient Te-Ba nuclei. We show that there is a larger α-particle formation probability in nuclei of this region above 100Sn when compared to analogous nuclei above 208Pb. This is consistent with the expected systematic variation of the pair gap Δ as a function of mass numb

Background: The negative impact of maternal smoking during pregnancy on offspring semen quality is well established. Less is known about the impact of paternal smoking. Methods: We estimated differences in semen parameters and testicle size according to paternal smoking in 772 adult sons of women enrolled in the Danish National Birth Cohort when pregnant. Parents’ smoking was reported around gesta

April 2013Scandinavian Journal of Disability Research 16(sup1):Active social citizenship: the case of disabled peoples' rights to personal assistance LicenseCC BY Karen ChristensenKaren ChristensenIngrid GuldvikIngrid GuldvikMonica LarssonMonica Larsson

Nanoerythrosomes (NERs), vesicle-like nanoparticles derived from red blood cells, represent a new and interesting vector for therapeutic molecules and imaging probes, mainly thanks to their high stability and excellent biocompatibility. Aiming to present a proof-of-concept of the use of NERs as diagnostic tools for in vitro/in vivo imaging purposes, we report here several functionalization routes

The mechanisms underlying M. fortuitum-induced pathogenesis remains elusive. Using headkidney macrophages (HKM) from Clarias gariepinus, we report that TLR-2-mediated internalization of M. fortuitum is imperative to the induction of pathogenic effects. Inhibiting TLR-2 signalling alleviated HKM apoptosis, thereby favouring bacterial survival. Additionally, TLR-2-mediated cytosolic calcium (Ca2+)c