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Children, teaching and the evolution of humankind

Social learning is essential for human evolution. To achieve such learning, cultural processes which trigger the development of active teaching and intergenerational transmission and accumulation of knowledge are needed. The understanding of how such systems and processes were developed over a long time is essential for our understanding of human evolution. The identification of children’s learnin

Association between low-density lipoprotein cholesterol-lowering genetic variants and risk of type 2 diabetes : A meta-analysis

IMPORTANCE Low-density lipoprotein cholesterol (LDL-C)-lowering alleles in or near NPC1L1 or HMGCR, encoding the respective molecular targets of ezetimibe and statins, have previously been used as proxies to study the efficacy of these lipid-lowering drugs. Alleles near HMGCR are associated with a higher risk of type 2 diabetes, similar to the increased incidence of new-onset diabetes associated w

An Evaluation of Information Meetings as a Tool for Addressing Fear of Large Carnivores

Managing authorities in Scandinavia arrange public information meetings when members of the public express fear because wolves or brown bears approach human settlements. This study aimed to increase the understanding of the potential effect of information meetings on self-reported fear of wolves and brown bears. In total, 198 participants completed questionnaires before and after the information m

Methodology and Applications of Visual Stance Analysis : An Interactive Demo

Analysis of stance in textual data can reveal the attitudes of speakers, ranging from general agreement/disagreement with other speakers to fine-grained indications of wishes and emotions. The implementation of an automatic stance classifier and corresponding visualization techniques facilitates the analysis of human communication and social media texts. Furthermore, scholars in Digital Humanities

A COMPARISON of STELLAR ELEMENTAL ABUNDANCE TECHNIQUES and MEASUREMENTS

Stellar elemental abundances are important for understanding the fundamental properties of a star or stellar group, such as age and evolutionary history, as well as the composition of an orbiting planet. However, as abundance measurement techniques have progressed, there has been little standardization between individual methods and their comparisons. As a result, different stellar abundance proce

Observation of the Chiral and Achiral Hexatic Phases of Self-assembled Micellar polymers

We report the discovery of a thermodynamically stable line hexatic (N + 6) phase in a three-dimensional (3D) system made up of self-assembled polymer-like micelles of amphiphilic molecules. The experimentally observed phase transition sequence nematic (N)⇌N + 6⇌two-dimensional hexagonal (2D-H) is in good agreement with the theoretical predictions. Further, the present study also brings to light th

Co-gasification of coal and biomass wastes in an entrained flow gasifier: Modelling, simulation and integration opportunities

Gasification processes convert carbon-containing material into syngas through chemical reactions in the presence of gasifying agents such as air, oxygen, and steam. Syngas mixtures produced from such processes consist mainly of carbon monoxide (CO), hydrogen (H2), carbon dioxide (CO2), and methane (CH4); this gas can be directly utilised as a fuel to produce electricity or steam. Besides, it is re

Overexpression of functional SLC6A3 in clear cell renal cell carcinoma

PURPOSE: Renal cell carcinoma (RCC) is derived from a tissue with a remarkable capacity for vectorial transport. We therefore performed an unbiased exploration of transporter proteins in normal kidney and kidney cancer in order to discover novel clinical targets.EXPERIMENTAL DESIGN: Using the TCGA database we investigated differences in membrane transporter expression in ccRCC and normal kidney. W

Evidence for new catecholamines or related amino acids in some invertebrate neurons

In certain sensory neurons of many different invertebrate species, including the sea anemones. Metridium senile and Tealia felina and the crustacean Anemia salina, fluorophores are formed during the course of the fluorescent histochemical technique of Falck-Hillarp. The presumed catecholamine nature of the neuronal fluorogenic compound was investigated by microspectrofluorometry, and the spectral In certain sensory neurons of many different invertebrate species, including the sea anemones. Metridium senile and Tealia felina and the crustacean Anemia salina, fluorophores are formed during the course of the fluorescent histochemical technique of Falck-Hillarp. The presumed catecholamine nature of the neuronal fluorogenic compound was investigated by microspectrofluorometry, and the spectral

18F-AV-1451 tau PET imaging correlates strongly with tau neuropathology in MAPT mutation carriers

Tau positron emission tomography ligands provide the novel possibility to image tau pathology in vivo. However, little is known about how in vivo brain uptake of tau positron emission tomography ligands relates to tau aggregates observed post-mortem. We performed tau positron emission tomography imaging with 18F-AV-1451 in three patients harbouring a p.R406W mutation in the MAPT gene, encoding tau

Methods to improve patient recruitment and retention in stroke trials

Background: The success of randomized-controlled stroke trials is dependent on the recruitment and retention of a sufficient number of patients, but fewer than half of all trials meet their target number of patients. Methods: We performed a search and review of the literature, and conducted a survey and workshop among 56 European stroke trialists, to identify barriers, suggest methods to improve r

Heat transfer and friction factor in a dimple-pin fin wedge duct with various dimple depth and converging angle

Purpose - The dimple is adopted into a pin fin wedge duct which is widely used in modern gas turbine vane cooling structure trailing edge region. The purpose of this paper is to study the effects of dimple depth and duct converging angle on the endwall heat transfer and friction factor in this pin fin wedge duct. Design/methodology/approach - The study is carried out by using the numerical simulat

A Flexible Link Function for Discrete-Time Duration Models

This paper proposes a discrete-time hazard regression approach based on the relation between hazard rate models and excess over threshold models, which are frequently encountered in extreme value modelling. The proposed duration model employs a flexible link function and incorporates the grouped-duration analogue of the well-known Cox proportional hazards model and the proportional odds model as s

Kinetics and Mechanism for Reduction of the Anticancer Prodrug trans,trans,trans-[PtCl2(OH)2(c-C6H11NH2)(NH3)] (JM 335) by Thiols

Reduction of the anticancer trans platinum(IV) prodrug JM335 by thiols in a moderately alkaline aqueous perchlorate medium is quite rapid and yields trans-[Pt(OH)2(c-C6H11NH2)(NH3)] as the reaction product. The mechanism of reduction involves reductive attack by thiol or thiolate on one of the mutually trans chloride ligands, leading to the formation of a chloride-bridged activated complex.The red

Dilations of anastomotic strictures over time after repair of esophageal atresia

Aim of the study: Anastomotic strictures commonly occur in patients undergoing surgery for esophageal atresia (EA). The primary aim of this study was to determine the age distribution of dilation procedures for anastomotic strictures over the patient’s childhood after reconstruction of EA. The secondary aim was to evaluate the effect of postoperative proton pump inhibitors (PPIs) on the frequency

Iohexol plasma clearance for measuring glomerular filtration rate in clinical practice and research : A review. Part 2: Why to measure glomerular filtration rate with iohexol?

A reliable assessment of glomerular filtration rate (GFR) is of paramount importance in clinical practice as well as epidemiological and clinical research settings. It is recommended by Kidney Disease: Improving Global Outcomes guidelines in specific populations (anorectic, cirrhotic, obese, renal and non-renal transplant patients) where estimation equations are unreliable. Measured GFR is the onl