Men with a low prostate-specific antigen (PSA) level (60 yr) owing to their low risk of aggressive prostate cancer (PCa). However, there is a subset of men who develop lethal PCa despite low baseline PSA. We investigated how a PCa polygenic risk score (PRS) in addition to baseline PSA impacts the prediction of lethal PCa among 483 men aged 40–70 yr from the Physicians’ Health Study followed over a

In this paper a Maximum likelihood estimation algorithm for Finite Impulse Response Errors-in-Variables systems is developed. We consider that the noise-free input signal is Gaussian-mixture distributed. We propose an Expectation-Maximization-based algorithm to estimate the system model parameters, the input and output noise variances, and the Gaussian mixture noise-free input parameters. The bene

The problem of state estimation of a linear, dynamical state-space system where the output is subject to quantization is challenging and important in different areas of research, such as control systems, communications, and power systems. There are a number of methods and algorithms to deal with this state estimation problem. However, there is no consensus in the control and estimation community o

This study examines whether and to what extent the bandwagon effect and the spiral of silence impact opinion formation in a polarized context, where individuals tend to be persistent in their policy attitudes. Focusing on contentious policy issues at the heart of the culture war in American politics, our aim is to study the relative importance of attitude persistence and social conformity in the o

From the end of the nineteenth century and one hundred years onward, home sewing was an important part of many women’s duties, but it was also a pleasure, something that existed parallel with the emerging mass-produced ready-to-wear industry. The paper patterns used for home dressmaking were often sold and distributed through women’s magazines. These pattern sections were both a kind of reader serFrom the end of the nineteenth century and one hundred years onward, home sewing was an important part of many women’s duties, but it was also a pleasure, something that existed parallel with the emerging mass-produced ready-to-wear industry. The paper patterns used for home dressmaking were often sold and distributed through women’s magazines. These pattern sections were both a kind of reader ser

Although invasive species are recognized as a major threat to freshwaters, little is known about how future climate warming will affect the success of invaders. Ecosystems are also often simultaneously impacted by multiple, potentially interacting, invading species and the management of species invasions can be incredibly difficult. Sensitive methods such as environmental DNA (eDNA) metabarcoding,

Background: Freshwaters are exposed to multiple anthropogenic stressors, leading to habitat degradation and biodiversity decline. In particular, agricultural stressors are known to result in decreased abundances and community shifts towards more tolerant taxa. However, the combined effects of stressors are difficult to predict as they can interact in complex ways, leading to enhanced (synergistic)

Meristem Wall is a prototype for a 3D-printed building envelope, featuring a dynamically controllable network of integrated air channels that allow a fl uid and adaptive relationship between inside and outside. The wall integrates functional lighting and electricity, windows, and a custom CNC-knitted textile interior. It is fabricated through binder-jet sand 3D printing and points towards a climat

Regulatory B (Breg) cells can dampen inflammation, autoreactivity and transplant rejection. We investigated the frequencies, phenotypes and function of Breg cells in granulomatosis with polyangiitis (GPA) to gain further knowledge to whether there are numerical alterations or limitations of their ability to regulate T-cell function. Frequencies and phenotypes of CD24 hiCD27 + and CD24 hiCD38 hi B-

This paper presents the foundations of a transrelational theory of moral agency, which extends the relational view with the idea that moral relationships include as well as transcend the descriptive criteria – e.g., in virtue of 1st person properties or 3rd person observables – of whatever makes someone a moral agent. The resultis a holistic picture that captures the complex interrelationship betwThis paper presents the foundations of a transrelational theory of moral agency, which extends the relational view with the idea that moral relationships include as well as transcend the descriptive criteria – e.g., in virtue of 1st person properties or 3rd person observables – of whatever makes someone a moral agent. The result is a holistic picture that captures the complex interrelationship bet

Reconfigurable Intelligent Surfaces (RIS) are well established as a promising solution to the blockage problem in millimeter-wave (mm-wave) and terahertz (THz) communications, envisioned to serve demanding networking applications, such as 6G and vehicular. HyperSurfaces (HSF) is a revolutionary enabling technology for RIS, complementing Software Defined Metasurfaces (SDM) with an embedded network

Programmable metasurfaces constitute an emerging paradigm, envisaged to become a key enabling technology for Reconfigurable Intelligent Surfaces (RIS) due to their powerful control over electromagnetic waves. The HyperSurface (HSF) paradigm takes one step further by embedding a network of customized integrated circuit (IC) controllers within the device with the aim of adding intelligence, connecti

HyperSurfaces (HSFs) consist of structurally reconfigurable metasurfaces whose electromagnetic properties can be changed via a software interface, using an embedded miniaturized network of controllers. With the HSF controllers, interconnected in an irregular, near-Manhattan geometry, we propose a robust, deterministic Fault-Tolerant (FT), deadlockand livelock-free routing protocol where faults are

Probabilistic flooding is commonly considered in vehicular ad-hoc networks (VANETs) to alleviate the celebrated broadcast storm problem. Heuristics and simulations have so far proved to be an efficient way with which to design probabilistic information dissemination solutions with demonstrated effectiveness. Supplementing with mathematical analysis for both design and evaluation is expected to gen

In this paper we model the criminal standard of proof as a twofold standard requiring sufficient probability of the factum probandum and sufficient informativeness. The focus of the paper is on the latter requirement, and we use decision theory to develop a model for sufficient informativeness. We demonstrate that sufficient informativeness is fundamentally a question of information economics and

BACKGROUND: To have an impact on the population's health, preventive interventions have to reach a large proportion of the intended population. Digital solutions show potential for providing wider access to fall preventive exercise. However, there is a lack of knowledge about how to reach the target group. The aim of this study was to describe the recruitment process used in the Safe Step randomis

Objective: To identify subgroups of patients with magnetic resonance imaging (MRI)-confirmed degenerative meniscus tears who may benefit from arthroscopic partial meniscectomy (APM) in comparison with non-surgical or sham treatment. Methods: Individual participant data (IPD) from four RCTs were pooled (605 patients, mean age: 55 (SD: 7.5), 52.4% female) as to investigate the effectiveness of APM i