Local infection control measures, antibiotic consumption and patient demographics from 1999-2000 together with bacteriological analyses were investigated in 29 ICUs participating in the ICU-STRAMA programme. The median antibiotic consumption per ICU was 1147 (range 605-2143) daily doses per 1000 occupied bed d (DDD1000). Antibiotics to which >90% of isolates of an organism were susceptible were de

In this thesis we study the backward shift operator on various spaces of analytic functions, and integral operators of Cesàro type also acting on various spaces of analytic functions.

Tobaksrökning är som tur är på nedåtgående i de flesta länder. Ändå är tobaksodlingen fortfarande en stor industri och många hoppas på att hitta nya användningsområden för denna giftiga växt. Lars Olof Björn och Ingvar Kärnefelt berättar tobakens historia ur ett både botaniskt och mänskligt perspektiv.

Background: Dose-dense (DD) adjuvant chemotherapy improves outcomes in early breast cancer (BC). However, there are no phase 3 randomized data to inform on its combination with trastuzumab for patients with human epidermal growth factor receptor 2 (HER2)–positive disease. Methods: This was a protocol-predefined secondary analysis of the randomized phase 3 Pan-European Tailored Chemotherapy (PANTHE

UNLABELLED: Tissue kallikrein is released in the body both physiologically and in many inflammatory disorders. Little is, however, known about the turnover of released tissue kallikrein in humans. Approximately 1 mg of tissue kallikrein (mol wt 43,000 Da) was purified from 85 L human urine by: (1) ultracentrifugation, (2) filtration through an aprotinin-coupled Sepharose 4B column, followed by (3)

The FLUKA code was applied to a simplified model of the tungsten target of the European Spallation Source (ESS) and shown to be suitable for modelling the radionuclide inventory of the ESS target. Two groups of radionuclides were selected based on dose factors and total predicted activities, one immediately after 5 years (designed lifetime of the target) of operation, and the other 10 years after

The differential invariant yield as a function of transverse momentum (pT) of electrons from semileptonic heavy-flavour hadron decays was measured at midrapidity in central (0–10%), semi-central (30–50%) and peripheral (60–80%) lead–lead (Pb–Pb) collisions at sNN=5.02 TeV in the pT intervals 0.5–26 GeV/c (0–10% and 30–50%) and 0.5–10 GeV/c (60–80%). The production cross section in proton–proton (p

Background: Comprehensive measures to evaluate the effectiveness of medical interventions in extremely preterm infants are lacking. Although length of stay is used as an indicator of overall health among preterm infants in clinical studies, it is confounded by nonmedical factors (e.g. parental readiness and availability of home nursing support). Objectives: To develop the PREMature Infant Index (P

Convolutional Neural Networks (CNNs) have been subject to extensive attention in the pattern recognition literature due to unprecedented performance in tasks of information extraction from unstructured data. Whereas available methods for supervised training of a CNN with a given network topology are well-defined with rigorous theoretical justification, procedures for the initial selection of topol

Aim: To describe the experience of distress in people with cancer of working age. Design: A cross-sectional study. Methods: In this cross-sectional study, patients (N = 168) with both ongoing (N = 56) and completed treatment (N = 105) completed the Distress Thermometer and the detailed problem list. Data were analysed by descriptive and analytical statistics. Results: A large proportion of patient

In the present paper, the heat transfer of gravity-driven dense particle flow around a hexagonal tube is numerically studied. The velocity vector, time-averaged particle contacting number, particle contacting time and heat transfer coefficient of particle flow are carfully analyzed. Furthermore, the heat transfer performances of particle flow around a hexagonal tube, circular tube and elliptical t

Background: A study was designed to assess a computer-based program for continuous registration of antibiotic resistance, statistics concerning severity of illness, and consumption of antibacterial drugs. Methods: The frequency of antibiotic resistance among bacteria in eight ICUs in southeastern Sweden was investigated yearly from 1995 through 1997. The antibiotic consumption in the ICUs was regi

Objective: We hypothesized that morphine has a depressing effect on early brain activity, assessed using quantitative aEEG/EEG parameter and depressed activity will be associated with brain volumes at term in extremely preterm infants. Study design: 174 preterm infants were enrolled in 3 European tertiary NICUs (mean GA:26 ± 1wks) and monitored during the first 72 h after birth with continuous 2 c

Background: Intensive care units (ICUs) are hot zones for emergence and spread of antibiotic resistance because of frequent invasive procedures, antibiotic usage and transmission of bacteria. We report prospective data on antibiotic use and bacterial resistance from 14 academic and non-academic ICUs, participating in the ICU-STRAMA programme 1999-2003. Methods: The quantity of antibiotics delivere