Public Procurement for Innovation (PPI) requires multiple roles from the public administration according to the problem-solution space, delineated by the level of consensus around the definition of the needs of the contracting authority and the potential solutions to address them. Each role involves a distinct mix of capabilities, which we categorize as ordinary (i.e. doing things right), dynamic

Sepsis is one of the leading causes of mortality in the world. Currently, the heterogeneity of sepsis makes it challenging to determine the molecular mechanisms that define the syndrome. Here, we leverage population scale proteomics to analyze a well-defined cohort of 1364 blood samples taken at time-of-admission to the emergency department from patients suspected of sepsis. We identified panels o

Creating typologies of forest owners is a common approach for analyzing and understanding heterogeneity in responses to forest policies and management practice uptake. While many forest owner typologies have been developed, only a few quantitative methods dominate the field with little information on how methodological choice affects outcomes. In this study we compare five methods for quantitative

As ectotherms, insects need heat-sensitive receptors to monitor environmental temperatures and facilitate thermoregulation. We show that TRPA5, a class of ankyrin transient receptor potential (TRP) channels absent in dipteran genomes, may function as insect heat receptors. In the triatomine bug Rhodnius prolixus (order: Hemiptera), a vector of Chagas disease, the channel RpTRPA5B displays a u

This thesis delves into the complex architecture of dynamic sensory information processing in the neocortex. Specifically, it asks how primary sensory cortical regions are influenced by local and widespread cortical state changes. Central to this question is the exploration of two historically opposing information processing frameworks emphasizing a local and global information processing principl

This report introduces the background and framing of the concept of mission portfolios, focusing on portfolios of actions. It describes portfolio management approaches, explaining the uses and benefits, as well as the challenges of applying a portfolio approach in mission implementation. Further, it presents several existing examples of portfolio approaches in practice at different levels of goverThis report introduces the background and framing of the concept of mission portfolios, focusing on portfolios of actions. It describes portfolio management approaches, explaining the uses and benefits, as well as the challenges of applying a portfolio approach in mission implementation. Further, it presents several existing examples of portfolio approaches in practice at different levels of gover

Relatively little is known about the relationship between socio-demographic factors and the chemical exposome in adolescent populations. This knowledge gap hampers global efforts to meet certain UN sustainability goals. The present work addresses this problem in Swedish adolescents by discerning patterns within the chemical exposome and identify demographic groups susceptible to heightened exposur

Peripheral nerves consist of delicate structures, including a rich microvascular system, that protect and nourish axons and associated Schwann cells. Nerves are sensitive to internal and external trauma, such as compression and stretching. Ulnar nerve entrapment, the second most prevalent nerve entrapment disorder after carpal tunnel syndrome, appears frequently at the elbow. Although often idiopa

This article shows how the Arctic landscapes in the Danish political drama series Borgen: Power & Glory demonstrate Greenland as a contested land in distinct ways: culturally due to the postcolonial tension between Denmark and Greenland; politically due to the conflicted interests from Denmark and other nations for the country’s natural resources; environmentally due to the looming transformat

Introduction: Fish β-parvalbumins are common targets of allergy-causing immunity. The nature of antibody responses to such allergens determines the biological outcome following exposure to fish. Specific epitopes on these allergens recognised by antibodies are incompletely characterised. Methods: High-content peptide microarrays offer a solution to the identification of linear epitopes recognised

Objectives The aim was to study the development of radiographic knee osteoarthritis (RKOA) in individuals with knee pain over 2 years, and the associations between radiographic changes and baseline variables. Design Longitudinal cohort study. Participants and setting This study is part of the Halland Osteoarthritis cohort. The included 178 individuals, aged 30-67, had knee pain, without cruciate l

En intellektuell funktionsnedsättning är en sårbarhetsfaktor förknippadmed diskriminering, stigmatisering och andra former avutsatthet. Att säkerställa att personer med intellektuell funktionsnedsättningfår sina intressen och rättigheter tillgodosedda i alla delar avrättssystemet är angeläget. Straffsystemet omfattar flera av samhälletsmest ingripande verktyg och gör anspråk på att fastställa skul

Background and aims: Obesity and type 2 diabetes are significant risk factors for atherosclerotic cardiovascular disease (CVD) worldwide, but the underlying pathophysiological links are poorly understood. Neurotensin (NT), a 13-amino-acid hormone peptide, facilitates intestinal fat absorption and contributes to obesity in mice fed a high-fat diet. Elevated levels of pro-NT (a stable NT precursor p

The Pythia8/Angantyr model for heavy ion collisions was recently updated with a mechanism for global colour reconnection. The colour reconnection model used is QCD colour algebra inspired and enhances baryon production due to the formation of string junctions. In this paper, we present updates to the junction formation and string fragmentation mechanisms, connected to heavy quark fragmentation. Th

Purpose: Traumatic brain injury is the main reason for the emergency department visit of up to 3% of the patients and a major worldwide cause for morbidity and mortality. Current emergency management guidelines recommend close attention to patients taking oral anticoagulation but not patients on antiplatelet therapy. Recent studies have begun to challenge this. The aim of this study was to determi

Here we present a new eastern Baltic Chironomidae training set (TS) containing 35 sites that was collected and merged with neighbouring published Finnish (82 lakes) and northern part of the Polish (nine lakes) TSs. Chironomidae, non-biting midges, are known to be strongly responsive to the July air temperature and are widely used to infer palaeotemperature. Several modern analogue-based TSs necess

The Sveconorwegian orogen in Scandinavia and the Grenville orogen in Canada are both remnants oflarge and hot orogens that formed part of the supercontinent Rodinia around 1 billion years ago. Formerly deeply buried portions of crust in these orogens are exposed and offer insights into the tectonic dynamics of the basement within large orogens. The Eastern Segment of the Sveconorwegian Province ho

Aims: Cognitive and perfusion changes have been previously observed in older men with Mini Mental State Examination scores>24 points. We aimed to investigate time change in cognitive domains in a cohort of non-demented men between age 68 and 82, and how they are expressed in regional defects estimated by Cerebral Blood Flow (rCBF). Methods: 103 men at age 81 with MMSE scores >24 (mean 28.4 ± 1.7),