MOTIVATION: Massively parallel reporter assays (MPRA) enable systematic screening of DNA sequence variants for effects on transcriptional activity. However, convenient analysis tools are still needed. RESULTS: We introduce MPRAscore, a novel tool to infer allele-specific effects on transcription from MPRA data. MPRAscore uses a weighted, variance-regularized method to calculate variant effect size

BACKGROUND AND OBJECTIVES: Changes in teachers' work situation in Sweden since the 1990s may have contributed to an increase in common mental disorders (CMDs) and burnout. However, there is a lack of research in this field. The aim was to describe how Swedish elementary school teachers experience their health, organizational and social work environment, and the psychosocial safety climate at the w

Genome-wide association studies have identified breast cancer risk variants in over 150 genomic regions, but the mechanisms underlying risk remain largely unknown. These regions were explored by combining association analysis with in silico genomic feature annotations. We defined 205 independent risk-associated signals with the set of credible causal variants in each one. In parallel, we used a Ba

In the 1990s the world economy was hit by a series of unusually deep crises with far-reaching consequences, the first of which occurred in Finland and Sweden. This paper compares the cost of the crisis of the 1990s with the costs caused by all major crises and depressions since the 1870s in the two Nordic countries. First, it constructs a crisis chronology for Finland and Sweden. Second, it estima

This report estimates possible macroeconomic effects of a pandemic taking place in the EU in 2006, using a quarterly macroeconomic model. The macroeconomic costs of a pandemic, that is the cost in terms of production lost due to illness and death measured as reductions in GDP growth and/or declines in the level of GDP, are quantified in various pandemic scenarios. We focus on two sectors of the Eu

Analys av sparbanken Finn och förslag att omvandla banken till en stiftelse och sälja banken för att skapa en mycket stor lokal investeringsfond.

Objective: Develop a generic trans-disciplinary, skills-based capability framework for health professionals providing care for people with OA. Design: e-Delphi survey. An international inter-professional Delphi Panel (researchers; clinicians; consumer representatives) considered a draft framework (adapted from elsewhere) of 131 specific capabilities mapped to 14 broader capability areas across fou

During corrosive dissolution of metal ions from a body surface, an oxide compound isproduced. This compound forms a protective film that reduces the dissolution rate. When afraction of a millimetre depth is dissolved the dissolution rate become insignificant. However,repeated loading will damage the film with continued dissolution as a result. In connectionwith this a threshold strain is assumed tDuring corrosive dissolution of metal ions from a body surface, an oxide compound isproduced. This compound forms a protective film that reduces the dissolution rate. When afraction of a millimetre depth is dissolved the dissolution rate become insignificant. However,repeated loading will damage the film with continued dissolution as a result. In connectionwith this a threshold strain is assumed t

BACKGROUND: Given today's high prevalence of common mental disorders and related sick leave among teachers, an urgent need exists for a more systematic approach to the management of social and organizational risk factors within schools. In 2015, we launched the first Swedish occupational health guideline to support a structured prevention of these risks at the workplace. The existence of guideline

Multiple myeloma (MM) is the second most common blood malignancy. Epidemiological family studies going back to the 1920s have provided evidence for familial aggregation, suggesting a subset of cases have an inherited genetic background. Recently, studies aimed at explaining this phenomenon have begun to provide direct evidence for genetic predisposition to MM. Genome-wide association studies have

Catheter ablation may reduce ventricular tachycardia (VT) burden in arrhythmogenic right ventricular cardiomyopathy (ARVC) patients. However, little is known about factors predicting need for ablation. Therefore, we sought to investigate predictors and use of VT ablation and to evaluate the postprocedural outcome in ARVC patients. We studied 435 patients from the Nordic ARVC registry including 220

Route search requires a useful and accurate algorithm to calculate the distance between two objects, especially on a round surface such as the earth. This algorithm provides a considerable circle distance between two locations on a non-flat surface. The distance of the two objects is determined based on longitude and latitude. Haversine is an algorithm that can determine the distance between two o

An investigation into the implementation state of open standards in software is currently ongoing through the ISPRS/EuroSDR 'GeoBIM benchmark 2019' initiative, which kicked off earlier this year. The benchmark activity provides a way of assessing and comparing the functionality of different software packages in GIS and BIM in terms of their ability to handle standardised data (IFC and CityGML) and

In both the Geo and BIM domains, it is widely acknowledged that the integration of geo-data and BIM-data is beneficial and a crucial step in facing the multi-disciplinary challenges of our built environment. The result of this integration - broadly termed as GeoBIM - has a range of potential uses from district study to road safety. However, from the data perspective, this integration raises the qu

There is no tradition in Annals of Regional Science that the editors write editorials. However, as of 2020, the editors will each year write an editorial in which we report as well as refect on recent developments of the journal. We hope that this will be of interest for our readers. This editorial is the frst one and marks the start of the strategy to write a yearly editorial. We, i.e., Martin An

Background: Providing continuous follow-up care to patients with congenital heart disease (CHD) remains a challenge in many settings. Previous studies highlight that patients with CHD experience discontinuation of follow-up care, but mainly describe a single-centre perspective, neglecting inter-institutional variations. Hospital-related factors above and beyond patient-related factors are believed

A numerical simulation is performed to identify the material parameters of an elastic/visco-plastic material under tensile impact loading. The identification is based on an inverse analysis using the Kalman filter technique and the finite element method. The input data to the inverse analysis are the time histories of the strains on specimens. The measurement errors can be treated reasonably by thA numerical simulation is performed to identify the material parameters of an elastic/visco-plastic material under tensile impact loading. The identification is based on an inverse analysis using the Kaiman filter technique and the finite element method. The input data to the inverse analysis are the time histories of the strains on specimens. The measurement errors can be treated reasonably by th

Low-temperature operation of solid oxide fuel cells (SOFCs) results in deterioration in electrochemical performance due to sluggish oxygen reduction reaction (ORR) at the cathode. To enhance the reaction pathway for ORR, La0.8Sr0.2MnO3 (LSM) nanofibers were fabricated by electrospinning and used for low-temperature solid oxide fuel cells operated at 600–700 °C. The morphological and structural cha