PURPOSE. To test the effects of rearing light intensity on retinal function and morphology in the retinoschisis knockout (Rs1-KO) mouse model of X-linked retinoschisis, and whether it affects functional outcome of RS1 gene replacement. METHODS. Seventy-six Rs1-KO mice were reared in either cyclic low light (LL, 20 lux) or moderate light (ML, 300 lux) and analyzed at 1 and 4 months. Retinal functio

MicroRNAs (miRNAs) are cellular, short, non-coding ribonucleotides acting as endogenous posttranscriptional repressors following incorporation in the RNA-induced silencing complex. Despite being chemically and mechanistically very similar, miRNAs exert a multitude of different cellular effects by acting on mRNA species, whose gene-products partake in a wide array of processes.Here, the aim was to

Climate change has the potential to affect the ecology and evolution of every species on Earth. Although the ecological consequences of climate change are increasingly well documented, the effects of climate on the key evolutionary process driving adaptation - natural selection - are largely unknown. We report that aspects of precipitation and potential evapotranspiration, along with the North Atl

Although reports of pharmaceutical bioconcentration in aquatic organisms are increasing, less is known about trophic transfer in aquatic food webs. The bioaccumulation and trophodynamics of sertraline and fluoxetine, 2 selective serotonin reuptake inhibitors (SSRIs) frequently detected in aquatic environments, were tested by exposing constructed aquatic food chains to SSRIs under controlled labora

Purpose We validate the usefulness of laser-induced autofluorescence for the detection of bladder carcinoma. Materials and Methods We obtained and analyzed fluorescence spectra from 75 patients in whom bladder cancer was suspected. Tissue fluorescence was excited by a nitrogen laser using a quartz optical fiber placed in gentle contact with the area of interest. The laser-induced autofluorescence

In this paper we use panel survey data on African smallholders and combine these with remotely sensed data to explore the possibilities of integrated explanations of maize (corn) yields and their development over time. We explore if such data can be used attain a transboundary explanation of smallholder yields, thus combining geo- and biophysical data with socio-economic ones. We show that, at thi

The adrenal-derived hormones dehydroepiandrosterone (DHEA) and its sulfate (DHEAS) are the most abundant circulating hormones and their levels decline substantially with age. DHEAS is considered an inactive precursor, which is converted into androgens and estrogens via local metabolism in peripheral target tissues. The predictive value of serum DHEAS for fracture risk is unknown. The aim of this s

Intressanta fynd från Blekinge av kärlväxter, mossor och lavar från framför allt 2015 rapporteras. Flertalet fynd finns inlagda i Artportalen.

Hur kan juridiken användas för att motverka strukturell diskriminering. Det är en av de många frågor som ställs i "Att förstå lagstiftning om diskrimineirng och mänskliga rättigheter". Syftet med boken är att ge kunskap och verktyg för rörelse ock aktivitet. I sju kapitel tas frågor upp genom exempel som handlar om bland annat anställning, rätten till bostad, löner och åldersdiskrimineirng. Gränse

We consider channel shortening (CS) algorithms for communication systems where multiple single antenna nodes are transmitting single carrier signals to a single antenna receiver over known intersymbol interference channels. We discuss seven methods to shorten the intersymbol interference (ISI) channels, and the parameters are optimized from a generalized mutual information (GMI) perspective. The m

A comparison of tenancy law in Denmark, Finland and Sweden