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Synthesis of 3-amido-3-deoxy-beta-D-talopyranosides: all-cis-substituted pyranosides as lectin inhibitors

3-Deoxy-3-amino-beta-D-talopyranosides have been synthesized for the first time. The amines were obtained from galactopyranosides through 2,3-anhydrogulosides that were opened to idosides followed by an oxidation/reductive amination sequence. From the amines, 11 corresponding 3-deoxy-3-arylamido-beta-talopyranosides have been synthesized and evaluated as inhibitors against galectin-1, -2, -3, -4C,

Associations of Supermarket Characteristics with Weight Status and Body Fat: A Multilevel Analysis of Individuals within Supermarkets (RECORD Study)

Purpose: Previous research on the influence of the food environment on weight status has often used impersonal measures food environment defined for residential neighborhoods, which ignore whether people actually use the food outlets near their residence. To assess whether supermarkets are relevant contexts for interventions, the present study explored between-residential neighborhood and between-

A PLL based 12 GHz LO generator with digital phase control in 90 nm CMOS

A 12 GHz PLL with digital output phase control has been implemented in a 90 nm CMOS process. It is intended for LO signal generation in integrated phased array transceivers. Locally placed PLLs eliminate the need of long high frequency LO routing to each transceiver in a phased array circuit. Routing losses are thereby reduced and the design of integrated phased array transceivers becomes more mod

Counting and Detecting Small Subgraphs via Equations

We present a general technique for detecting and counting small subgraphs. It consists of forming special linear combinations of the numbers of occurrences of different induced subgraphs of fixed size in a graph. These combinations can be efficiently computed by rectangular matrix multiplication. Our two main results utilizing the technique are as follows. Let H be a fixed graph with k vertices an

Walking in old age: A year-round perspective on accessibility in the outdoor environment and effects of measures taken

Accessibility throughout society has been gaining interest on both international and national levels in order to meet the transportation needs of, for example, older people as pedestrians. The overall aim of this thesis is to examine the implementation process in municipal planning, and effects of measures taken, to achieve barrier-free outdoor environments the year round. Older peoples’ perceptio

Alignment of the ALICE Inner Tracking System with cosmic-ray tracks

ALICE (A Large Ion Collider Experiment) is the LHC (Large Hadron Collider) experiment devoted to investigating the strongly interacting matter created in nucleus-nucleus collisions at the LHC energies. The ALICE ITS, Inner Tracking System, consists of six cylindrical layers of silicon detectors with three different technologies; in the outward direction: two layers of pixel detectors, two layers e

Core and valence exciton formation in x-ray absorption, x-ray emission and x-ray excited optical luminescence from passivated Si nanocrystals at the Si L-2,L-3 edge

Resonant inelastic x-ray scattering (RIXS), x-ray absorption spectroscopy and x-ray excited optical luminescence (XEOL) have been used to measure element specific filled and empty electronic states over the Si L-2,L-3 edge of passivated Si nanocrystals of narrow size distribution ( diameter 2.2 +/- 0.4 nm). These techniques have been employed to directly measure absorption and luminescence specifi

The adult human brain harbors multipotent perivascular mesenchymal stem cells.

Blood vessels and adjacent cells form perivascular stem cell niches in adult tissues. In this perivascular niche, a stem cell with mesenchymal characteristics was recently identified in some adult somatic tissues. These cells are pericytes that line the microvasculature, express mesenchymal markers and differentiate into mesodermal lineages but might even have the capacity to generate tissue-speci

Integrating Open Access Geospatial Data to Map the Habitat Suitability of the Declining Corn Bunting (Miliaria calandra)

The efficacy of integrating open access geospatial data to produce habitat suitability maps for the corn bunting (Miliaria calandra) was investigated. Landsat Enhanced Thematic Mapper Plus (ETM+), Shuttle Radar Topography Mission (SRTM) and Corine (Coordination of Information on the Environment) land cover data for the year 2000 (CLC2000) were processed to extract explanatory variables and divided

High-resolution crystal structures of the flavoprotein NrdI in oxidized and reduced states - an unusual flavodoxin: Structural biology.

The small flavoprotein NrdI is an essential component of the class Ib ribonucleotide reductase system in many bacteria. NrdI interacts with the class Ib radical generating protein NrdF. It is suggested to be involved in the rescue of inactivated diferric centres or generation of active dimanganese centres in NrdF. Although NrdI bears a superficial resemblance to flavodoxin, its redox properties ha

Diet, Health and Agriculture : The Late Neolithic-Early Bronze Age Example of Abbekås, Southern Sweden

Diet and health during the Late Neolithic and Early Bronze Age Scandinavia have never been under systematic study. Still, high statures have been reported from osteologists, statures that indicate good health. This article is based on a pilot study examining health changes in relation to dietary changes due to intensified agriculture and the possible Secondary Products Revolution as discussed by S

Gender differences in lumbar disc herniation surgery

BACKGROUND AND PURPOSE: Although there have been numerous publications on lumbar disc herniation (LDH) treated surgically, there has been little interest in sex differences. It has been shown in many studies that sex differences may be important in certain diseases. We therefore reviewed consecutive register material from one institution for possible gender differences in pre- and postoperative pa

Pooling control in variable preparative chromatography processes.

Preparative chromatographic columns that run at high loads are highly sensitive to batch-to-batch disturbances of the process parameters, placing high demands on the strategy used for pooling of the product fractions. A new approach to pooling control is presented in a proof-of-concept study. A model-based sensitivity analysis was performed identifying the critical process parameters to product pu

Mellan makten och himmelriket : perspektiv på Hallands medeltida kyrkor.

The aim of the thesis is to discuss church building, the architectural design of Romanesque and Gothic churches and the use and symbolic interpretation of church buildings in the medieval period. It is suggested that churches were built for a variety of reasons, that the construction process may have been complicated and that the final result was not always the expected one. Many social groups wer

Improvement in survival of diffuse large B-cell lymphoma in relation to age, gender, International Prognostic Index and extranodal presentation: a population based Swedish Lymphoma Registry study

Our aim was to describe a large population-based cohort of diffuse large B-cell lymphoma (DLBCL) during the last decade, evaluating possible improvement in survival and to identify subgroups in need of novel treatment strategies. The study population encompassed all patients diagnosed with DLBCL in Sweden from 2000 through 2010. Altogether 5349 patients were identified. There was no increase in in

Karl Pearson and the Scandinavian school of statistics

The relationship between Karl Pearson and the Scandinavian statisticians was more of a competitive than a collaborative nature. We describe the leading statisticians and stochasticists of the Scandinavian school, and relate some of their work to the work of Pearson.