I am not convinced that the challenge for self-adaptive software is how to handle unexpected changes. I believe that the real challenge is how to characterise the uncertainty that the self-adaptive software has to handle. Once a proper characterisation of the uncertainty is in place, I think handling unanticipated changes and situations becomes a lot simpler. What is difficult is to know what rang

The European Spallation Source, currently under construction in Lund, Sweden, will be the world's most powerful neutron source. It is driven by a proton linac with a current of 62.5 mA, 2.86 ms long pulses at 14 Hz. The final section of its normal-conducting front-end consists of a 39 m long drift tube linac (DTL) divided into five tanks, designed to accelerate the proton beam from 3.6 MeV to 90 M

The Environmental Determinants of Diabetes in the Young (TEDDY) study enrolled 8676 children, 3-4 months of age, born with HLA-susceptibility genotypes for islet autoimmunity (IA) and type 1 diabetes (T1D). Whole-genome sequencing (WGS) was performed in 1119 children in a nested case-control study design. Telomere length was estimated from WGS data using five tools: Computel, Telseq, Telomerecat,

Metrics are instrumental in design assessments. Solar performance metrics help designers to evaluate solar access in cities. Metrics should be used early in the urban planning stages in order to enable sustainable urban development with greater access to solar energy. Currently, solar assessments at this design stage are limited in practice; established methods or routines are lacking, and so are

OBJECTIVE: Copy number variation of the C4 complement components, C4A and C4B, has been associated with systemic inflammatory autoimmune diseases. We asked if C4 copy number variation is connected to the autoimmune repertoire in systemic lupus erythematosus (SLE), primary Sjögren's syndrome (pSS) or myositis.METHODS: Using targeted DNA sequencing, we determined the copy number and genetic variants

The lack of methods to evaluate mechanical function of donated hearts in the context of transplantation imposes large precautionary margins, translating into a low utilization rate of donor organs. This has spawned research into cyber-physical models constituting artificial afterloads (arterial trees), that can serve to evaluate the contractile capacity of the donor heart.The Windkessel model is a

Putins invasion av Ukraina var – till skillnad från vad vissa menat – högst väntat och Putins agerande är i linje med den ryska säkerhetspolitiska strategin. Putin är varken galen eller oförutsägbar. Det är också för tidigt att säga att den ryska invasionen är misslyckad eftersom att mycket tyder på att den ryska strategin går ut på att utmatta motståndaren. Det skriver statsvetaren Ardavan KhoshnPutin's invasion of Ukraine was - contrary to popular belief - highly anticipated and Putin's actions are in line with Russia's security policy strategy. Putin is neither crazy nor unpredictable. It is also too early to say that the Russian invasion has failed because there are many indications that the Russian strategy is to exhaust the opponent. This is what political scientist Ardavan Khoshnood

Land subsidence is an increasing human-induced disaster that not only damages building and transportation structures but also diminishes the water storage capacity of the aquifers. Land subsidence is a very complex phenomenon impacted by various geo-environmental and hydrological factors. Application of the interferometric synthetic aperture radar (InSAR) is becoming a common approach to detect la

This article introduces the concept of the exit spiral to conceptualize processes in which poorly functioning hospital clinics or wards enter a phase of decline due to widespread dissatisfaction among staff, prompting turnover contagion. In describing and analyzing cases amassed during observations and interviews, the article provides tools to identify, analyze and halt exit spirals. Once a hospit

Age-related macular degeneration (ARMD) is one of the most debilitating eye-related illnesses worldwide. Eye-movement training is evolving to be a non-invasive, rapid, and effective method that is positively impacting vision and QoL (quality of life) in patients suffering from ARMD. This review aims to highlight why a greater adoption of eye-movement training in the clinical and research setting i

Around 90% of the energy requirement for urban water systems management is for heating domestic tap water. In addition, the energy content of wastewater is mainly in the form of heat (85%). Hence, there is an obvious interest in recovering a large portion of this heat. However, city-wide scenario analyses that evaluate heat recovery at various locations while considering impacts on wastewater trea

Within a broader definition of design, as the conception and planning of everything that is artificial, the place of tools is central. With the help of cognitive semiotics in general and Donald’s theory of the evolution of the human mind in particular, we propose a stage model for the evolution of design, consisting of four stages: Proto-design, Simple design, Complex design, and Advanced design,

An increasing proportion of penicillin-susceptible Staphylococcus aureus (PSSA) has been reported over the last years. The aim of this retrospective study was to compare penicillin G with cloxacillin in the treatment of PSSA bloodstream infections. The primary outcome was the mortality rate after 90 days and the secondary outcome was the development of treatment complications of varying severity.

BACKGROUND: The rate of cognitive decline in the early stages of Alzheimer's disease (AD) is variable, which may be partly due to genetic factors. We therefore investigated genetic predictors of longitudinal cognitive decline in AD. METHOD: In the Swedish BioFINDER study, we used polygenic scores (PGS) (of AD, intelligence and educational attainment), and genetic variants (in a genome-wide associa