Assemblies formed by a well-defined quality of DNA (4331 bp T7 DNA) and the small net-cationic protein lysozyme in dilute aqueous solutions have been characterized using cryo-transmission electron microscopy (cryo-TEM) and dynamic light scattering (DLS) as the main techniques. In a wide range of different DNA to lysozyme ratios in solutions of low ionic strength, dispersions of aggregates with the

Genetic differences among neoplastic cells within the same tumour have been proposed to drive cancer progression and treatment failure. Whether data on intratumoral diversity can be used to predict clinical outcome remains unclear. We here address this issue by quantifying genetic intratumoral diversity in a set of chemotherapy-treated childhood tumours. By analysis of multiple tumour samples from

Mammographic density reflects the composition of the breast tissue and can be measured by different methods. Mammography has a lower sensitivity in women with dense breasts, and women with dense breasts have a higher incidence of breast cancer than do women with non–dense breasts. Furthermore, there has been an increased interest in improving the measurement of mammographic density. The aim of thi

The mol-ecule of the title compound, C14H13N5O2, is approximately planar (r.m.s deviation for all non-H atoms = 0.093 Å), with the planes of the two pyridine rings inclined to one another by 5.51 (7)°. The oxime group is syn to the amide group, probably due to the formation of an intra-molecular N-H⋯N hydrogen bond that forms an S(6) ring motif. In the crystal, mol-ecules are linked by pairs of bi

Ideally, neuronal functions would be studied by performing experiments with unconstrained animals whilst they behave in their natural environment. Although this is not feasible currently for most animal models, one can mimic the natural environment in the laboratory by using a virtual reality (VR) environment. Here we present a novel VR system based upon a spherical projection of computer generate

Context.Innovation is promoted in companies to help them stay competitive. Four types of innovation are defined: product, process, business, and organizational. Objective. We want to understand the perception of the innovation concept in industry, and particularly how the innovation types relate to each other. Method. We launched a survey at a branch of a multi-national corporation. Results. From

Kan barndomens häpnad över ”märkvärdiga ting” påverka våra vuxna värderingar? För inte så länge sedan – ännu i mannaminne – visades exotiska folkslag på cirkus. Färgar detta första möte med det annorlunda vår människosyn?

In this study, a new supercritical fluid chromatography-mass spectrometry (SFC-MS) method has been developed for the separation of nine vitamin D metabolites within less than eight minutes. This is the first study of analysis of vitamin D and its metabolites carried out by SFC-MS. Six columns of orthogonal selectivity were examined, and the best separation was obtained by using a 1-aminoanthracene

Popular Abstract in Swedish Hur går det egentligen till när beslut fattas om nya, och för skattebetalarna kostsamma, väg- och järnvägsinvesteringar? Fattas besluten på basis av objektiva utredningar och noggranna kalkyler, eller är de ett resultat av politiska förhandlingar och spel mellan olika intressen? I denna avhandling undersöks investeringsplanering som politisk beslutsprocess dels genom enInvestment planning is a decision-making process with specific characteristics. It is often seen as a rational quest for solutions that are in the public interest, and the dominant discourse tends to be technical and economic. Public documents reproduce this picture of a decision-making process based on rationalist premises where analytical methods and objective facts form the basis for decisions.

ASHEIM B. The changing role of learning regions in the globalizing knowledge economy: a theoretical re-examination, Regional Studies. Highlighting four theoretical developments, this paper theoretically re-examines the learning region in view of the changing roles of regions in the globalizing knowledge economy: (1) from specific contexts to general regional development strategies; (2) introducing

Objective. To investigate the type of urinary diversion performed after cystectomy in patients with muscle-invasive bladder cancer in Sweden, using data from a population-based national register. Material and methods. Since 1997, the Swedish Bladder Cancer Register has included more than 90% of all patients with newly diagnosed bladder cancer. The different types of urinary diversion performed in

High-spin states in I-122 have been investigated using the Cd-116(B-11,5n)I-122 reaction at a beam energy of 65 MeV and gamma-ray coincidence events were recorded with the INGA spectrometer. The level scheme of I-122 has been extended up to spin I = 30. Experimental features, such as band-crossing frequencies, aligned angular momenta, signature splitting, and B(M1)/B(E2) ratios have been used for

Integration of first- and second-generation ethanol production can facilitate the introduction of second-generation lignocellulosic ethanol production. Consolidation of the second-generation with the first-generation process can potentially reduce the downstream processing cost for the second-generation process as well as providing the first-generation process with energy. This study presents nove

The background of this study is a project aiming at assessing the quality of teaching and learning in scientific computing in different cultural settings. This, we hope will lead us to constructing standards, which can provide outcomes of comparable quality in scientific computing in different countries and societies. Specifically we want to gain insight which quality benchmarks are suitable for t

ABSTRACT: The ever increasing social cost that society pays for illness and disease are currently steadily increasing in many countries in the world today. These changes in society becomes a major financial burden that activates politicians and health care organizations in order to find new solutions. Biobanks are becoming the new powerful modality within the field of modern Life Science, that is

The aim of this paper is to conduct an analysis of the changing geographies of production and industrial renewal in Sweden during the period 1978 to 2004. Conceptually, we build on the regional version of the technology shift cycle thesis. This is performed in two steps and by combinations of national and regional empirical evidence. First, we construct a taxonomic method that distinguishes betwee

Klimatet har varit relativt stabilt under den nuvarande interglaciala epoken (Holocen) som inleddes för ungefär 11 700 år sedan. Genom klimatrekonstruktioner från olika geologiska arkiv såsom iskärnor, sjösediment och torvmossar har det ändå påvisats att snabba förändringar i klimatet har inträffat under denna epok. En sådan tidsperiod inträffade för omkring 2800 år sedan och den är intressant ur Geological archives have shown periods of abrupt climate change in the relatively stable Holocene epoch (last ca. 11 700 years). One of these periods was around 2800 cal BP. Several records, mainly from Europe, reveal a shift towards wetter, cooler and windier conditions. There are, however, indications for a global extent of the climate change. The climate change coincides with a distinct increas

The neuronal endoplasmic reticulum (ER) contributes to many physiological and pathological processes in the brain. A subset of dendritic spines on hippocampal neurons contains ER that may contribute to synapse-specific intracellular signaling. Distribution of ER to spines is dynamic, but knowledge of the regulatory mechanisms is lacking. In live cell imaging experiments we now show that cultured h

Background: Socio-economic inequalities in mortality are observed at the country level in both North America and Europe. The purpose of this work is to investigate the contribution of specific risk factors to social inequalities in cause-specific mortality using a large multi-country cohort of Europeans. Methods: A total of 3,456,689 person/years follow-up of the European Prospective Investigation