Dimers of A beta (amyloid beta-protein) are believed to play an important role in Alzheimer's disease. In the absence of sufficient brain-derived dimers, we studied one of the only possible dimers that could be produced in vivo, [A beta](DiY) (dityrosine cross-linked A beta). For comparison, we used the A beta monomer and a design dimer cross-linked by replacement of Ser(26) with cystine [A beta S

Introduction An estimated 2.4 [1.8–3.2] million people in the WHO European Region now live with HIV, and none of the Region’s 53 countries have been spared. The epidemic is spreading most rapidly in western Europe among migrants and men who have sex with men, and in eastern Europe among male injecting drug users – and increasingly their sexual partners. This doctoral research investigates several

The main purpose of this project has been to examine the accessibility of refereed conference articles and the OAand publishing policies of conferences in order to in this way elucidate different aspects concerning self-archiving in Swedish institutional repositories. For this purpose, the project participants have examined a number of conferences and references to conference articles via their in

The effects of dryer fabric cooling were studied. Using a dryer fabric cooled to a temperature below the dew point of the air-vapour mixture resulted in condensation of water vapour in the fabric structure. This condensation process was studied by means of a small-scale dynamic pilot dryer. The novel model on mass and heat transport in dryer fabrics, described in part 1, was validated against expe

Excited-state dynamics of carotenoids has attracted considerable recent interest, but it has also engendered a number of controversial hypotheses. This review summarizes the knowledge gathered from various ultrafast time-resolved techniques addressing the two most discussed dark excited states (1B(u)(-) and S*). These two states have been subjects of numerous earlier studies, because while the 1B(

Syftet med avhandlingen är att beskriva och analysera hur Försäkringskassans organisationskultur har förändrats. Mer specifikt är syftet att fånga förändringarna i Försäkringskassans organisationskultur genom att studera tjänstemännens relationer, reaktioner och handlingsstrategier över tid. De centrala frågeställningarna är följande: ”Hur har försäkringskassans organisationskultur förändrats?”, ”In 2005, The Swedish Social Insurance Agency (Försäkringskassan), was reformed from being local county authorities to a nationalized and integrated organization. The aim of this thesis is to describe how Försäkringskassan’s organizational culture has changed. The key questions are: ”How has Försäkringskassan’s culture changed?”, ”How are the organizational culture perceived and handled by the empl

Background: In Uganda, adolescent pregnancy often results in adverse maternal and neonatal health outcomes. In this context, low use of contraception and high rates of maternal mortality rate make preventing unwanted pregnancies critical. Objective: The objective was to determine the relationship between non-use of contraception and sociodemographic factors, alcohol consumption, and types of partn

NILE ("New Improvements for Lignocellulosic Ethanol") was an integrated European project (2005-2010) devoted to the conversion of lignocellulosic raw materials to ethanol. The main objectives were to design novel enzymes suitable for the hydrolysis of cellulose to glucose and new yeast strains able to efficiently converting all the sugars present in lignocellulose into ethanol. The project also in

Background and purpose - Treatment of Dupuytren's contracture (DC) with collagenase Clostridium histolyticum (CCH) consists of injection followed by finger manipulation. We used a modified method, injecting a higher dose than recommended on the label into several parts of the cord, which allows treatment of multiple joint contractures in 1 session and may increase efficacy. We studied the occurren

The spin and configurational structure of excited states of Cd-127, the two-proton and three-neutron hole neighbor of Sn-132, has been studied. An isomeric state with a half-life of 17.5(3) mu s was populated in the fragmentation of a Xe-136 beam on a Be-9 target at a beam energy of 750 MeV/u. Time distributions of the delayed gamma transitions and gamma gamma coincidence relations were exploited

Objective Psychosocial adversity is a risk factor for cardiovascular disease (CVD) in adults. The authors assessed associations of reactive hyperaemia peripheral arterial tonometry (RH-PAT), a measure of endothelial function predictive of CVD, with self-assessed psychological health among school children. Methods A total of 248 healthy school children (mean (SD) age 14.0 (1.0); 136 girls and 112 b

The dimeric metabolic enzyme phosphoglucose isomerase (PGI, EC 5.3.1.9) plays an essential role in energy production. In the grass Festuca ovina, field surveys of enzyme variation suggest that genetic variation at cytosolic PGI (PGIC) may be adaptively important. In the present study, we investigated the molecular basis of the potential adaptive significance of PGIC in F. ovina by analyzing cDNA s

Percutaneous closure of secundum atrial septal defect associated with situs solitus and dextrocardia has not been reported previously. We describe the technical difficulties encountered during transcatheter closure of a secundum atrial septal defect in a 19-month-old girl with situs solitus and dextrocardia.

This thesis deals with various aspects of growth, convergence and technological change, all analysed from an empirical perspective. A common theme throughout the six chapters is the analysis of economic historical questions of productivity growth with the use of quantitative statistical techniques. An introductory chapter is followed by two chapters on the Western European regional growth and conv

The need to consider n-ary algebraic structures, generalizing Lie and Poisson algebras, has become increasingly important in physics, and it should therefore be of interest to study the mathematical concepts related to n-ary algebras. The purpose of this paper is to investigate ternary multiplications (as deformations of n-Lie structures) constructed from the binary multiplication of a Hom-Lie alg