We describe RosettaRemodel, a generalized framework for flexible protein design that provides a versatile and convenient interface to the Rosetta modeling suite. RosettaRemodel employs a unified interface, called a blueprint, which allows detailed control over many aspects of flexible backbone protein design calculations. RosettaRemodel allows the construction and elaboration of customized protoco

A phylogenetic analysis of xanthorioid lichens of the lichen family Teloschistaceae, based on ITS rDNA and mtSSU sequences, is presented. The data set includes 201 specimens representing 50 species, covering the xanthorioid lichen group, which resulted in 183 new sequences. Five well-supported groups were recognized in the MP analysis: 1) Seirophora, 2) the Xanthoria s. str.-Xanthodactylon group,

Popular Abstract in Swedish Syfte: Att undersöka den prediktiva precisionen hos ålder för missbruksdebut, MAO-B aktiviteten i blod, samt olika kombinationer av kriminologiska och kliniska riskfaktorer med avseende på återfall i våldsbrott hos tidigare våldsbrottsdömda i en prospektiv svensk uppföljningsstudie. Studiepopulation: Hundra våldsbrottslingar, konsekutivt intagna för rättspsykiatrisk undObjective: To test the predictive accuracy for violent recidivism of the age at onset of substance abuse, the platelet MAO-B activity, and various combinations of criminological and clinical risk factors among violent offenders in a prospective Swedish follow-up study. Subjects: One hundred violent offenders, consecutively admitted for forensic psychiatric investigations between 1998 and 2001 (bas

Context: Several text books and articles published between 2000 and 2002 have attempted to introduce experimental design and statistical methods to software engineers undertaking empirical studies. Objective: This paper investigates whether there has been an increase in the quality of human-centric experimental and quasi-experimental journal papers over the time period 1993 to 2010. Method: 70 exp

European educational knowledge and practices have been deeply impacted by the colonial experience. While hegemonic knowledge was exported to the colonies, practices of teaching and governing colonial subjects were tested in the periphery and then re-imported to the center. This contribution looks at a case of European education outside Europe that did not take place, at least not entirely, in a co

The chapter describes and discusses some of the most prominent historical buildings in the county of Kalmar.

Adsorption of glycine on Pt{111} under UHV conditions and in different aqueous environments was studied by XPS (UHV and ambient pressure) and NEXAFS. Under UHV conditions, glycine adsorbs in its neutral molecular state up to about 0.15 ML Further deposition leads to the formation of an additional zwitterionic species, which is in direct contact with the substrate surface, followed by the growth of

Immunotherapy of malignant primary brain tumors holds the potential to improve the dismal prognosis after current clinical therapy. Although immunotherapy of experimental gliomas has been demonstrated to have the capacity to cure intracerebral tumors no convincing effects of immunotherapy have been shown in clinical trials. One reason for this could be that some of the models used do not display f

Rheumatoid arthritis (RA) is a systemic disease not only restricted to the joints, but can also be associated with the development of extra-articular manifestations. Extra-articular RA (ExRA) is of clinical importance because of the associated morbidity and increased risk of premature mortality compared with RA patients in general. The aims of this work were to identify patients with ExRA in early

Popular Abstract in English Prostate cancer is one of the most common cancers in the world and the second most common in men. The western world has the highest incidence rates. The causes of prostate cancer are not yet clear, however a number of risk factors have been identified such as familial history, ethnicity, diet and genetic events. Prostate cancer affects primarily elderly men with the majProstate cancer is the second most common cancer in men. In order to improve diagnosis and prognosis, new sensitive and specific biomarkers are needed. Tissue biomarkers carry expression and morphological information of the tissue where they are expressed. However their use is still limited by technological problems, lack of standardized procedures and inadequate interpretation. In this work we in

The opportunistic human pathogen Pseudomonas aeruginosa causes a wide range of diseases. To cross host innate immune barriers, P. aeruginosa has developed efficient strategies to escape host complement attack. In this study, we identify the 57-kDa dihydrolipoamide dehydrogenase (Lpd) as a surface-exposed protein of P. aeruginosa that binds the four human plasma proteins, Factor H, Factor H-like pr

Organometallic complexes containing terminal metal nitrides and phosphides are important synthetic reagents. Laser-ablated group 6 metal atoms react with NF3, PF3, and PCl3 to form the simple lowest energy N MF3, and P MX3 products following insertion and halogen transfer, with the exception of P CrF3, which is a higher energy species and is not observed. The E MX3 pnictide metal trihalide molecul

microRNAs (miRNAs) are widespread regulators of gene expression, but little is known of their potential roles in congenital muscular dystrophy type 1A (MDC1A). MDC1A is a severe form of muscular dystrophy caused by mutations in the gene encoding laminin α2 chain. To gain insight into the pathophysiological roles of miRNAs associated with MDC1A pathology, laminin α2 chain-deficient mice were evalua

Charged particle production in deep-inelastic ep scattering is measured with the H1 detector at HERA. The kinematic range of the analysis covers low photon virtualities, 5 < Q(2) < 100 GeV2, and small values of Bjorken-x, 10(-4) < x < 10(-2). The analysis is performed in the hadronic centre-of-mass system. The charged particle densities are measured as a function of pseudorapidity (n(*)) and trans