Objective: To investigate (i) the performance and agreement between various activity indices and response criteria in TNF-blockade of RA; (ii) the predictive ability of different response criteria and disease activity states regarding continuation of anti-TNF treatment of RA; (iii) Euro-QoL-5-dimensions utility development during TNF blockade of RA, PsA and SpA. Also, (iv) to develop a simple, uti

Abstract in German In diesem Kapitel beschäftigen wir uns mit vier Hindernissen, die einer produktiven Forschung über einen möglichen Einfluss der Sprache auf das Denken im Weg stehen. Zunächst ist da die Behauptung, es sei unmöglich, Sprache vom Denken zu trennen, die Frage des „Einflusses“ sei also nichtig. Als zweites gibt es das Argument, es sei unmöglich, Sprache von Kultur allgemein, insbesoIn this article, we discuss four obstacles that stand in the way for a productive investigation into the kind of influence that language may have on thinking. The first is that it is impossible to distinguish language from thought, so that the question of possible “influence” is mute. The second is that it is impossible to disentangle language from culture in general, and from social interaction i

Popular Abstract in Swedish Hjärtat pumpar blod genom ett nätverk av blodkärl, vilket för ut syre och näringsämnen till organen och för tillbaka restprodukter som bryts ned eller utsöndras från kroppen. När hjärtat pumpar byggs det upp ett tryck som driver blodet genom kärlsystemet, från artärter till vener via ett förgrenat nät av kapillärer, som svarar för utbytet med vävnadsvätskorna. BlodflödeSmooth muscle cells residing in the blood vessel media are constantly exposed to mechanical forces exerted by the intraluminal pressure. The smooth muscle senses and adapts to mechanical forces by activation of multiple signaling pathways and cytoskeletal rearrangements. Stretch of the vascular wall is therefore an important factor that controls smooth muscle cell phenotype and function. The goal

We present a method for determining a temperature differential across a quantum dot. If the device has a transmission function with sufficiently spaced resonant energies, then one can distinguish electrons which have tunneled from the hot lead, and those which have tunneled from the cold lead. By measuring the thermocurrent as the electrochemical potential is swept through a resonant energy level,

En av de verkligt stora frågorna i den samtida retorikteorin är förhållandet till det klassiska arvet. Retoriken kan sägas vara det moderämne i den humanistiska bildningstraditionen som många ämnen inom humaniora har avknoppats från, och därför är det inte lika självklart att det nya är bättre än det gamla när retorikforskare ser på sitt eget ämne. Andrea A.Lunsford är en av de ledande retorikfors

The skeleton is a common site of cancer metastasis. Notably high incidences of bone lesions are found for breast, prostate, and renal carcinoma. Malignant bone tumors result in significant patient morbidity. Identification of these lesions is a critical step to accurately stratify patients, guide treatment course, monitor disease progression, and evaluate response to therapy. Diagnosis of cancer i

The objective of this nationwide prospective cohort study is to find out the risk of breast cancer (BC) in relatives of patients with multiple BCs by laterality and age at diagnosis of first BC. Having family history of single (HR 1.8; 95 % CI 1.8-1.9) or multiple (HR 2.7; 95 % CI 2.6-2.9) BC was associated with higher risk of BC. Those with an FDR with contralateral BC at any age had the highest

Background and purpose The Artelon CMC spacer is designed for surgical treatment of osteoarthritis (OA) in the carpometacarpal joint of the thumb (CMC-I). Good results using this degradable device were previously presented in a pilot study. We now present results from a larger randomized, controlled, multicenter study. Patients and methods 109 patients (94 females) with a mean age of 60 (42-83) ye

The energy balance at most surface-atmosphere flux research sites remains unclosed. The mechanisms underlying the discrepancy between measured energy inputs and outputs across the global FLUXNET tower network are still under debate. Recent reviews have identified exchange processes and turbulent motions at large spatial and temporal scales in heterogeneous landscapes as the primary cause of the la

This Letter presents a search for high-mass resonances decaying into tau(+)tau(-) final states using proton-proton collisions at root s = 7 TeV produced by the Large Hadron Collider. The data were recorded with the ATLAS detector and correspond to an integrated luminosity of 4.6 fb(-1). No statistically significant excess above the Standard Model expectation is observed; 95% credibility upper limi

This work presents studies of the valence band of two Kondo lattice systems: Ce2Co0.8Si3.2, which is paramagnetic with the Kondo temperature T-K approximate to 50 K and Ce2RhSi3, which is antiferromagnetic below T-N = 4.5 K and exhibits TK approximate to 9 K. The photoemission spectra, which are obtained with photon energy tuned to Ce - 4d 4f resonance, reveal a Kondo peak at the Fermi energy (E-F

Chronic obstructive pulmonary disease is a major cause of increased morbidity and mortality. The aim of this study was to investigate hospital admission rates among individuals with symptoms of chronic bronchitis and among those with airflow limitation corresponding to GOLD stages 1-4. Method: Between 1974 and 1992, 22 044 middle-aged individuals participated in a health screening, which included

Background and purpose The role of synovitis and high fluid pressure in the loosening process after total hip arthroplasty has gained increasing attention. We investigated the correlation between head size, polyethylene wear, and capsular distention. Patients and methods We analyzed 39 unrevised, radiographically stable hips that had been operated with 28 or 32 mm femoral heads 10 years earlier be

We report on In0.53Ga0.47As n-channel multiple-gate field-effect transistors (MuGFETs or FinFETs) with a novel method of selectively regrown lateral (parallel to substrate) nanowires as channels. The device exhibits a minimum subthreshold slope of 85 mV/decade and drain-induced barrier lowering of 88 mV/V at V-DS = 0.05 V and L-G = 200 nm. At V-DS = 0.5 V, (gm), (max) = 1.67 mS/mu m is achieved (L

The article departs from an overarching research question: How does young people's engagement in different Internet spaces affect the development of their public orientation during adolescence? It analyses longitudinal panel data in order to explore how young people's public orientation develops during a phase in life (13–20) which is critical for political socialization. Data are derived from thr

In the days before the term “high-grade undifferentiated pleomorphic sarcoma” came into use, one of the most common sarcoma diagnoses was “malignant fibrous histiocytoma,” and before that, in an era before immunohistochemistry, “fibrosarcoma” was used to describe most sarcomas. “Spindle cell” is a descriptive phrase that denotes the cellular shape of many of the sarcomas encountered in the adult p

The objective of the present study was to evaluate the cost-utility of bariatric surgery in a lifetime horizon from a Swedish health care payer perspective. A decision analytic model using the Markov process was developed covering cardiovascular diseases, type 2 diabetes, and surgical complications. Clinical effectiveness and safety were based on the literature and data from the Scandinavian Obesi

Most findings on the triple helix system derive from studies based on high-tech sectors, and seldom so on traditional industries. A foresight exercise aimed at renewal of the mature food industry in the Skåne region in southern Sweden was conducted in 2006-2007. The findings suggest that a multilevel triple helix policy ought to be used in a systemic way from a bottom up perspective, including com