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Linear and nonlinear optical properties of metallic nanocrystals in sapphire

In this paper we report the linear and non-linear optical properties of metallic nano-clusters in α-Al 2O 3 fabricated by ion implantation (from 2 to 8×10 16 ions/cm 2). Thereafter, the samples were annealed at temperatures from 600 to 1100°C in oxidising, reducing atmospheres. Once spherical nano-particles were synthesized, the samples were further irradiated with Si +++ with different energies a

The Meridian S03E04 : Finding the way using starlight

Astronomers, such as Nic and Rebecca, are not the only ones orienting themselves using the stars. Animals, big and small, also navigate by starlight. In this last episode of the third season we invited Prof. Marie Dacke from the Department of Biology over to tell us about her research on the subject.In this third season we are also including some Cosmic Curiosities. These are some ideas, events or

Organoids from nephrotic disease-derived iPSCs identify impaired NEPHRIN localization and slit diaphragm formation in kidney podocytes

Mutations in the NPHS1 gene, which encodes NEPHRIN, cause congenital nephrotic syndrome, resulting from impaired slit diaphragm (SD) formation in glomerular podocytes. However, methods for SD reconstitution have been unavailable, thereby limiting studies in the field. In the present study, we established human induced pluripotent stem cells (iPSCs) from a patient with an NPHS1 missense mutation, a

Novel inflammatory biomarkers in postural orthostatic tachycardia syndrome

IntroductionPostural Orthostatic Tachycardia Syndrome (POTS) is a disorder characterized by excessive orthostatic tachycardia and orthostatic intolerance. While traditional inflammatory biomarkers tend to be normal, a subclinical inflammatory process may be present in POTS.PurposeWe aimed to analyse novel inflammatory biomarkers in POTS patients: Growth Differentiation Factor 15 (GDF15), Neutrophi

Algorithmic Trading, Human against AI

This thesis examines how the performance of a rule based trading algorithm, the Golden Cross Trading Algorithm, and an Artificial Neural Network constructed algorithm, the Long Short-Term Memory, perform against each other and a buy- and-hold strategy, when trading on the equity market. The underlying assets will be nine large American tech companies, all listed on Nasdaq. In order to distinguish

Revisiting the Standard of Proof for Charges of Exceptional Gravity before the International Court of Justice

The International Court of Justice has consistently required a stricter standard of proof for ‘charges of exceptional gravity’. The Bosnia Genocide and Croatia Genocide cases saw the Court require the high standard of ‘fully conclusive’ evidence across all elements of the allegations of genocide. Despite the difficulties associated with obtaining the necessary evidence of the intent of the perpetr

The New CERN Low-energy Facilities for Neutrino Detector Tests

The beamlines at CERN's North and East Areas offer secondary beams in a wide range of momenta between 0.5 GeV/c and 400 GeV/c for fixed-target experiments as well as for test beam campaigns with a flexible configuration and variable beam composition and intensities. Recently, two new facilities for neutrino detectors tests have been established in an extension of the CERN North Area in context of

Multicentre Studies

The first part of the chapter provides an introduction on the implementation of quality-assurance programmes in nuclear medicine (NM) services. It is argued that participation in interlaboratory comparisons has two main benefits. First, on top of existing local quality-assurance programmes, participation can add a level of reassurance on quality. Second, interlaboratory comparisons are prerequisit

Activity Quantification from Planar Images

Planar imaging was for a long time the most-used technique for image-based activity quantification. Owing to its simplicity and speed, the possibility to acquire dynamic image sequences, and to generate whole-body images at a reasonable acquisition time, it is still frequently used in nuclear-medicine imaging. Today, planar imaging is most commonly used for diagnostic examinations with qualitative

A computational study of the reaction mechanism and stereospecificity of dihydropyrimidinase

Dihydropyrimidinase (DHPase) is a key enzyme in the pyrimidine pathway, the catabolic route for synthesis of β-amino acids. It catalyses the reversible conversion of 5,6-dihydrouracil (DHU) or 5,6-dihydrothymine (DHT) to the corresponding N-carbamoyl-β-amino acids. This enzyme has the potential to be used as a tool in the production of β-amino acids. Here, the reaction mechanism and origin of ster

Cardiac q-space trajectory imaging by motion-compensated tensor-valued diffusion encoding in human heart in vivo

Purpose: Tensor-valued diffusion encoding can probe more specific features of tissue microstructure than what is available by conventional diffusion weighting. In this work, we investigate the technical feasibility of tensor-valued diffusion encoding at high b-values with q-space trajectory imaging (QTI) analysis, in the human heart in vivo. Methods: Ten healthy volunteers were scanned on a 3T sca

Ever Smoking is Not Associated with Performed Spirometry while Occupational Exposure and Respiratory Symptoms are

Objective: Despite recommendations, assessment using spirometry or peak expiratory flow is insufficient in the clinical evaluation of suspected obstructive pulmonary disease. The aim was to investigate factors associated with performing spirometry or peak flow expiratory flow assessment. Methods: Randomly selected subjects from the general population aged 50–65 completed a respiratory questionnair

Does a good story prompt visit intention? Evidence from the augmented reality experience at a heritage site in China

The emergence of digital technology has led researchers, businesses, and entrepreneurs to reflect more on the potential value that Augmented Reality (AR) can play in tourism. Although the relationship between authenticity and travel intention has been examined previously, little is known about how authenticity influences tourist travel intention after an AR experience. To fill this research gap, t

Photodissociation of bromine-substituted nitroimidazole radiosensitizers

Heavy elements and some nitroimidazoles both exhibit radiosensitizing properties through different mechanisms. In an effort to see how the overall radiosensitivity might be affected when the two radiosensitizers are combined in the same molecule, we studied the gas-phase photodissociation of two brominated nitroimidazoles and a bromine-free reference sample. Synchrotron radiation was employed to i