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Basic Atomic and Nuclear Physics

Nuclear medicine and molecular imaging are mostly based on radioactive elements that, when decaying due to an excess of energy, emit radiation in the form of electromagnetic radiation (photons), or by charge-particles (electron, positrons, or alpha particles). The first part of this chapter describes in general the atom and its components and states some definitions important for further reading.

Etikprövningslagen och funktionsrättskonventionen: normkonflikter och reformbehov

Huvudsyftet med etisk reglering av forskning på människor har alltid varit att skydda dessa. Vissa grupper, såsom personer med nedsatt beslutsförmåga, har setts som sårbara och därför i behov av särskilda skyddsregler. Nyligen har dessa regler kritiserats för att vara överbeskyddande, försvåra viktig forskning, och bryta mot mänskliga rättigheter, såsom FN:s Konvention om rättigheter för personer

Single Photon Emission Computed Tomography (SPECT) and SPECT/CT Hybrid Imaging

Images created using a standard collimator-based scintillation camera are essentially 2D images, lacking information regarding the source depth, since the value in a particular pixel in the image represents detection of photons along a line determined by the collimator. However, it is possible to reconstruct a set of 2D images that together form a 3D image of the underlying activity distribution f

Monte Carlo Simulation of Nuclear Medicine Imaging Systems

This chapter describes the use of the Monte Carlo method to simulate nuclear medicine imaging systems, mainly the scintillation camera – SPECT (Single-Photon Emission Computed Tomography) and PET (Positron Emission Tomography) – systems that are major tools in nuclear medicine to produce images of activity distributions. The first part describes the principles behind the Monte Carlo method, in par

Academic freedom and the anti-Israeli BDS movement

Raphael Cohen-Almagor looks at the Boycott, Divestment, Sanctions (BDS) campaign to boycott Israeli academics and ban Israel tout court. He argues that there is no justification for any academic organisation to do this. Any such decision would be unjust, unfair, and counterproductive

Addressing a century-old hypothesis – do pioneer beetles of Ips typographus use volatile cues to find suitable host trees?

Global warming and more frequent climate extremes have caused bark beetle outbreaks of unprecedented scale of these insects in many conifer forests world-wide. Conifers that have been weakened by drought and heat or damaged by storms are highly susceptible to bark beetle infestation. A large proportion of trees with impaired defences provides good conditions for beetle population build-up of beetl

Exposure to phenoxyacetic acids and glyphosate as risk factors for non-Hodgkin lymphoma– pooled analysis of three Swedish case-control studies including the sub-type hairy cell leukemia

The association between pesticide exposure and non-Hodgkin lymphoma (NHL) including hairy cell leukemia (HCL) was analyzed in a pooled study of three case-control studies. Results on exposure to pesticides were based on 1,425 cases and 2,157 controls participating in the studies. Exposures were assessed by self-administered questionnaires completed as needed by phone. In the pooled univariate anal

The optimal operative protocol to accomplish CO2-EVAR resulting from a prospective interventional multicenter study

Objectives: Carbon dioxide (CO2) angiography for endovascular aortic repair (CO2-EVAR) is used to treat abdominal aortic aneurysms (AAAs), especially in patients with chronic kidney disease or allergy to iodinated contrast medium (ICM). However, some technical issues regarding the visualization of the lowest renal artery (LoRA) and the best quality image through angiographies performed from pigtai

Veno-arterial CO2 difference and lactate for prediction of early mortality after cardiac arrest

Patients admitted to intensive care after cardiac arrest are at risk of circulatory shock and early mortality due to cardiovascular failure. The aim of this study was to evaluate the ability of the veno-arterial pCO2 difference (∆pCO2; central venous CO2 – arterial CO2) and lactate to predict early mortality in postcardiac arrest patients. This was a pre-planned prospective observational sub-study

Warming, permafrost thaw and increased nitrogen availability as drivers for plant composition and growth across the Tibetan Plateau

Permafrost-affected ecosystems are subject to warming and thawing, which can increase the availability of subsurface nitrogen (N) with consequences in otherwise N-limited tundra and alpine vegetation. Here, we quantify the extent of warming and permafrost thawing and the corresponding effects on nitrogen availability and plant growth based on a 20-year survey across 14 sites on the Tibetan Plateau

Modelling managed forest ecosystems in Sweden : Poster presentation:

In this work, the forestry-enabled dynamic vegetation model LPJ-GUESS was used to simulate forest standing volume for the three main regions of Sweden. At the regional scale, the model results were evaluated against observational data from the Swedish National Forest Inventory. Carbon fluxes of net ecosystem exchange (NEE), gross primary productivity (GPP), and ecosystem respiration (Reco) were si

Uncertainties surrounding the oldest fossil record of diatoms

Molecular clocks estimate that diatom microalgae, one of Earth’s foremost primary producers, originated near the Triassic–Jurassic boundary (200 Ma), which is close in age to the earliest, generally accepted diatom fossils of the genus Pyxidicula. During an extensive search for Jurassic diatoms from twenty-five sites worldwide, three sites yielded microfossils initially recognized as diatoms. Afte

Enhanced protein synthesis is a defining requirement for neonatal B cell development

The LIN28B RNA binding protein exhibits an ontogenically restricted expression pattern and is a key molecular regulator of fetal and neonatal B lymphopoiesis. It enhances the positive selection of CD5+ immature B cells early in life through amplifying the CD19/PI3K/c-MYC pathway and is sufficient to reinitiate self-reactive B-1a cell output when ectopically expressed in the adult. In this study, i

The five self-harm behavior groupings measure : empirical and thematic data from a novel comprehensive self-harm assessment

INTRODUCTION: The Five Self-Harm Behavior Groupings Measure (5S-HM) is a novel assessment that evaluates behaviours which may go undetected by existing measures. Self-harm is formulated across directness and lethality spectra, including under-studied behaviors such as indirect self-harm, harmful self-neglect and sexual self-harm. Aims of the study were to: (1) empirically evaluate the 5S-HM; (2) t

Abstract 5710: Detection and monitoring of t(11;14) in liquid biopsies from patients with relapsed/refractory multiple myeloma treated with venetoclax-based regimens

Venetoclax (Ven) is a selective B-cell lymphoma 2 inhibitor being studied in t(11;14)+ relapsed/refractory multiple myeloma (MM). Detection of t(11;14) in MM requires bone marrow (BM) aspiration and evaluation of CD138+ plasma cells by fluorescence in situ hybridization (FISH). Innovative techniques may provide less invasive detection of t(11;14) in liquid biopsies Here we present results of the S