It is now established that the transcription factors E2A, EBF1 and Foxo1 have critical roles in B cell development. Here we show that E2A and EBF1 bound regulatory elements present in the Foxo1 locus. E2A and EBF1, as well as E2A and Foxo1, in turn, were wired together by a vast spectrum of cis-regulatory sequences. These associations were dynamic during developmental progression. Occupancy by the

The design of multiple antennas in compact mobile terminals is a significant challenge, due to both practical and fundamental design tradeoffs. In this paper, fundamental antenna design tradeoffs of multiple antenna terminals are presented in the framework of characteristic mode analysis. In particular, interactions between the antenna elements and the characteristic modes and their impact on desi

To make transportation safer, more efficient, and less harmful to the environment, traffic telematics services are currently being intensely investigated and developed. Such services require dependable wireless vehicle-to-infrastructure and vehicle-to-vehicle communications providing robust connectivity at moderate data rates. The development of such dependable vehicular communication systems and

Balland P.-A., Boschma R. and Frenken K. Proximity and innovation: from statics to dynamics, Regional Studies. Despite theoretical and empirical advances, the proximity framework has remained essentially static. A dynamic extension of the proximity framework is proposed that accounts for co-evolutionary dynamics between knowledge networking and proximity. For each proximity dimension, how proximit

A novel polymeric material, off-stoichiometry thiol-ene-epoxy (OSTE+), has been evaluated for the fabrication of neural implants. OSTE+ is easily photo-structurable and exhibits mechanical properties suitable for stable implantation of the probe into brain tissue, while being sufficiently soft at physiological temperatures to reduce living tissue damage. The facile processing of OSTE+ allows use i

Frontotemporal dementia (FTD) is considered to be a mainly early-onset neurodegenerative disorder with a strong hereditary component. The aim of the study was to investigate age-related incidence and family history in FTD compared to other dementia disorders, especially Alzheimer's disease (AD).

The Swedish Arctic Ocean-96 expedition arranged by the Swedish Polar Research Committee took place during 1996 with the Swedish icebreaker M/S Oden. The expedition focused on studying the distribution of radionuclides in different water masses in the central Arctic Ocean. The expedition crossed the Barents Sea, entered the Nansen Basin at the St. Anna Trough, and continued north across the Amundse

The surgeon, who treats nerve injuries, should have knowledge about how peripheral nerves react to trauma, particularly an understanding about the extensive pathophysiological alterations that occur both in the peripheral and in the central nervous system. A large number of factors influence the functional outcome, where the surgeon only can affect a few of them. In view of the new knowledge about

Community screening to guide preventive interventions for acute aortic disease has been recommended in high-risk individuals. We sought to prospectively assess risk factors in the general population for aortic dissection (AD) and severe aneurysmal disease in the thoracic and abdominal aorta.

A systemic nature of allergic diseases has been hypothesized. As part of this discussion, we studied if adolescent allergic wheeze and increasing combinations of allergic organ involvements (lung, nose and skin) would also increase the reporting of other health problems (headache, muscle pain and abdominal pain). In addition, we studied if parental asthma was associated with adolescent clustering

Background: The prevalence of blindness and visual impairment from glaucoma is influenced by the criteria used to define these entities, which differ between countries and regions, as well as among published reports. The objective of the present study was to ascertain the extent to which different criteria of blindness and visual impairment influence estimates of the number of patients classified