BACKGROUND: The UN's Sustainable Development Goals (SDGs) are grounded in the global ambition of "leaving no one behind". Understanding today's gains and gaps for the health-related SDGs is essential for decision makers as they aim to improve the health of populations. As part of the Global Burden of Diseases, Injuries, and Risk Factors Study 2016 (GBD 2016), we measured 37 of the 50 health-relate

MOTIVATION: Neutrophil extracellular traps (NETs) are believed to be essential in controlling several bacterial pathogens. Quantification of NETs in vitro is an important tool in studies aiming to clarify the biological and chemical factors contributing to NET production, stabilization and degradation. This estimation can be performed on the basis of fluorescent microscopy images using appropriate

The porcine and human pathogen Streptococcus suis induces and degrades neutrophil extracellular traps (NETs) in vitro. In this study, we investigated the working hypothesis that NET degradation is mediated not only by the known secreted S. suis nuclease A (SsnA) but also by a so-far undescribed putative endonuclease A of S. suis (designated EndAsuis) homologous to the pneumococcal endonuclease A (

The formation of neutrophil extracellular traps (NETs) as a host innate immune defence mechanism has been shown to be the result of a novel cell death process called NETosis. The objective of this study was to investigate the role of cholesterol in the formation of NETs. To this end, primary human neutrophils were treated with different concentrations of methy-β-cyclodetxrin (MβCD) to reduce chole

In this paper we are investigating how project complexity is affecting the management of single projects in a multi-project environment. The project manager’s perspective is applied. A conceptual framework is developed in order to summarize how project complexity effect project management. The framework is applied to two cases and conclusions are drawn.

Metallic cast components inevitably contain defects such as shrinkage cavities which are inherent to the solidification process. Those defects are known to significantly alter the fatigue life of components. Yet very little is known, quantitatively, on the dangerosity of internal casting defects compared to surface ones. In this study, fatigue specimens containing controlled internal defects (shri

Series of fast synchrotron X-ray tomographies are taken continuously at a rate of up to 5Hz, while aluminium alloy precursors are foamed in an X-ray transparent setup for several minutes using infra-red (IR) lasers for heating. The entire foaming process from the solid precursor to the expanded liquid foam is captured. The analysis of the sequence of tomographies is done with an emphasis on nuclea

Abstract The microstructure of porous silver layers produced under different low temperature pressure-assisted sintering conditions is characterized and linked with the mechanical behavior studied insitu during X-ray diffraction. Peak profile analysis reveals important strain recovery and hardening mechanism during cyclic deformation. The competition between both mechanisms is discussed in terms o

Visible light Zernike phase contrast (ZPC) microscopy is a well established method for imaging weakly absorbing samples. The method is also used with hard x-ray photon energies for structural evaluation of material science and biological applications. However, the method suffers from artifacts that are inherent for the Zernike image formation. In this Letter, we investigate their origin and experi

Simultaneous optimisation of several criteria is an important and interesting subject. Even the standard H2-case is non-trivial. The problem is here treated for the general MIMO case for two conflicting objectives (the results directly generalise to several performance measures). A seminorm D2 is introduced to describe the situation. The state-space solution technique in [Khargonekar and Rotea, 19

Background: Arterial hypertension is common in adults with repaired coarctation of the aorta, and is associated with several severe complications. Aims: This study aimed to investigate the prevalence of poorly controlled (⩾140/90 mmHg) blood pressure among patients with diagnosed hypertension and to identify associated factors. Methods: In the national register for CHD, adults with repaired coarct

OBJECTIVE:: Carotid–femoral pulse wave velocity (CFPWV), a marker of aortic stiffness, has been associated with cognitive test results and markers of cerebral small vessel disease, but its association with dementia has not been studied in detail. Our aim was to assess the association of CFPWV with prevalent and incident dementia in a large population-based study. METHODS:: In total, CFPWV was meas

In this paper, we introduce the concept of spatially coupled turbo-like codes (SC-TCs) as the spatial coupling of a number of turbo-like code ensembles. In particular, we consider the spatial coupling of parallel concatenated codes, introduced by Berrou et al., and that of serially concatenated codes (SCCs), introduced by Benedetto et al. Furthermore, we propose two extensions of braided convoluti

This paper aims to contribute to the knowledge on how the concept of ‘collaboration’ is being produced and reproduced – and filled with meaning – as it is articulated in news content and opinion articles about the organisation of knowledge production within higher education in Sweden. We build on a textual analysis on the public discussion in the aftermath of the announcement of the research polic