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Biochemical and structural characterisation of membrane-containing icosahedral dsDNA bacteriophages infecting thermophilic Thermus thermophilus

Icosahedral dsDNA viruses isolated from hot springs and proposed to belong to the Tectiviridae family infect the Gram-negative thermophilic Thermus thermophilus bacterium. Seven such viruses were obtained from the Promega Corporation collection. The structural protein patterns of three of these viruses, growing to a high titer, appeared very similar but not identical. The most stable virus, P23-77

Extracellular matrix: paving the way to the newest trends in atherosclerosis

PURPOSE OF REVIEW: The extracellular matrix (ECM) is critical for all aspects of vascular pathobiology. In vascular disease the balance of its structural components is shifted. In atherosclerotic plaques there is in fact a dynamic battle between stabilizing and proinflammatory responses. This review explores the most recent strides that have been made to detail the active role of the ECM - and its

A somatic proteoglycan controls Notch-directed germ cell fate

Communication between the soma and germline optimizes germ cell fate programs. Notch receptors are key determinants of germ cell fate but how somatic signals direct Notch-dependent germ cell behavior is undefined. Here we demonstrate that SDN-1 (syndecan-1), a somatic transmembrane proteoglycan, controls expression of the GLP-1 (germline proliferation-1) Notch receptor in the Caenorhabditis elegan

Validation and clinical value of the MANAGE-PD tool : A clinician-reported tool to identify Parkinson's disease patients inadequately controlled on oral medications

Introduction: Making Informed Decisions to Aid Timely Management of Parkinson's Disease (MANAGE-PD) is a clinician-reported tool designed to facilitate timely identification and management of patients with advancing Parkinson's disease (PD) with suboptimal symptom control while on standard therapy. The objective of this study was to evaluate the validity and clinical value of the tool. Methods: Dr

Thrombin-derived C-terminal peptide reduces Candida-induced inflammation and infection in vitro and in vivo

Infections due to the opportunistic fungus Candida have been on the rise in the last decades, especially in immunocompromised individuals and hospital settings. Unfortunately, the treatments available today are limited. Thrombin-derived C-terminal peptide (TCP-25) is an antimicrobial peptide (AMP) with antibacterial and immunomodulatory effects. In this work, we, for the first time, demonstrate th

Adaptive Bayesian SLOPE : Model Selection With Incomplete Data

We consider the problem of variable selection in high-dimensional settings with missing observations among the covariates. To address this relatively understudied problem, we propose a new synergistic procedure—adaptive Bayesian SLOPE with missing values—which effectively combines SLOPE (sorted l 1 regularization) with the spike-and-slab LASSO (SSL) and is accompanied by an efficient stochastic ap

Prevalence of suicidal behavior and associated clinical correlates in patients with behavioral addictions

Addictive disorders are characterized by severe consequences, including suicidal events, but most studies investigating the association between addiction and suicidal risk have focused on substance use disorders and gambling disorder at the expense of the rest of behavioral addictions. This study examined the prevalence and the associated clinical correlates of suicidal ideation and suicide attemp

Early onset externalizing behaviors among forensic psychiatric patients : Identification in child and adolescent psychiatric services

Forensic psychiatric patients constitute a heterogeneous patient group, with common comorbidity within the externalizing spectrum. Increased knowledge on early antecedents in the pathway to severe mental illness and criminality is needed. In this study, we investigated early onset externalizing behaviors in three groups of forensic psychiatric patients 1) patients without contact with child and ad

Disruption of a GATA2-TAL1-ERG regulatory circuit promotes erythroid transition in healthy and leukemic stem cells

Changes in gene regulation and expression govern orderly transitions from hematopoietic stem cells to terminally differentiated blood cell types. These transitions are disrupted during leukemic transformation, but knowledge of the gene regulatory changes underpinning this process is elusive. We hypothesized that identifying core gene regulatory networks in healthy hematopoietic and leukemic cells

Dispositional self-consciousness and hypnotizability

The abeyance of self-consciousness (SC) during hypnosis has beendiscussed as a central aspect of hypnosis, yet dispositional SC hasbeen very rarely evaluated as a correlate of hypnotizability. In thisstudy (N = 328), the authors administered the Harvard Group Scaleof Hypnotic Susceptibility (HGSHS), the Inventory Scale of HypnoticDepth (ISHD), and the Self-Consciousness Scale-Revised (SCS-R).Women

The influence of ammonia on the laminar burning velocities of methylcyclohexane and toluene : An experimental and kinetic modeling study

Laminar burning velocities of methylcyclohexane and toluene blended with ammonia have been determined using the heat flux method at atmospheric pressure and initial temperature of 338 K, over equivalence ratios ranging from 0.7 to 1.3 and ammonia blending fractions in the binary fuel mixtures from 0 to 90%. It was observed that the addition of ammonia to methylcyclohexane and toluene leads to a de

Atrial Fibrillation, Stroke, and Silent Cerebrovascular Disease : A Population-based MRI Study

Background and ObjectivesAtrial fibrillation (AF) has been associated with cognitive decline and dementia. However, the mechanisms behind these associations are not clear. Examination of cerebrovascular pathology on MRI may shed light on how AF affects the brain. This study aimed to determine whether AF is associated with a broad range of cerebrovascular diseases beyond the well-known association

Association Between Estrogen Receptors and GATA3 in Bladder Cancer : A Systematic Review and Meta-Analysis of Their Clinicopathological Significance

Background: Estrogen receptors alpha (ERα) and beta (ERβ) and the cooperating protein GATA-binding factor 3 (GATA3) have been implicated in bladder carcinogenesis and tumour progression. GATA3 and ER have been functionally linked in the establishment of luminal fate in breast tissue, but to date their relationship in bladder cancer has not been established. This information will be useful to advan

Effects of livestock and wildlife grazing intensity on soil carbon dioxide flux in the savanna grassland of Kenya

Although grazing is the primary land use in the savanna lowland of southern Kenya, the effects of grazing on soil carbon dioxide flux (RS) remain unclear. A 12-month study was conducted from January to December 2020 on the effects of six grazing intensities sites (overgrazed (OG), heavily grazed (HG), moderately grazed (MG), moderately to lightly grazed (M-LG), lightly grazed (LG) and no grazing (

Long-term exposure to transportation noise and risk of incident stroke : A pooled study of nine scandinavian cohorts

BACKGROUND: Transportation noise is increasingly acknowledged as a cardiovascular risk factor, but the evidence base for an association with stroke is sparse. OBJECTIVE: We aimed to investigate the association between transportation noise and stroke incidence in a large Scandinavian population. METHODS: We harmonized and pooled data from nine Scandinavian cohorts (seven Swedish, two Danish), total

Genes from oxidative phosphorylation complexes II-V and two dual-function subunits of complex I are transcribed in Viscum album despite absence of the entire mitochondrial holo-complex I

Mistletoes (Viscum) and close relatives are unique among flowering plants in having a drastically altered electron transport chain. Lack of complex I genes has previously been reported for the mitochondrial genome, and here we report an almost complete absence of nuclear-encoded complex I genes in the transcriptome of Viscum album. Compared to Arabidopsis with approximately 40 nuclear complex I ge

e-learning and web-based tools for psychosocial interventions addressing neuropsychiatric symptoms of dementia during the covid-19 pandemic in tokyo, japan : Quasi-experimental study

Background: Concern has been raised that the COVID-19 pandemic and consequent social distancing measures may increase neuropsychiatric symptoms in people with dementia. Thus, we developed and delivered an e-learning training course to professional caregivers on using a web-based tool for psychosocial interventions for people with dementia. Objective: The aim of our study was to evaluate the feasib

Does microbiological contamination of homografts prior to decontamination affect the outcome after right ventricular outflow tract reconstruction?

OBJECTIVES: Homografts are often in short supply. Today, European guidelines recommend that all tissues contaminated by any of 18 different bacteria and fungi be discarded before antibiotic decontamination has been conducted. The tissue bank in Lund uses more liberal protocols: It accepts all microbes prior to decontamination except multiresistant microbes and Pseudomonas species. The aim of this

Development of an EAT-Lancet index and its relation to mortality in a Swedish population

BACKGROUND: Current global food systems threaten human health and environmental sustainability. In 2019, the EAT-Lancet Commission on healthy diets from sustainable food systems defined the first global reference diet to improve both areas, but there is no consensus on how to quantify the EAT-Lancet reference diet as a diet index and its relation to mortality has not been widely studied.OBJECTIVE: