Antigen-presenting cells (APCs) are a heterogenous group of immune cells composed by dendritic cells (DCs) and macrophages (Mϕ), which are critical for orchestrating immunity against cancer or infections. Several strategies have been explored to generate APC subsets, including enrichment from peripheral blood and differentiation from pluripotent or multipotent cells. During development, the genera

BACKGROUND: Respiratory syncytial virus (RSV) and influenza cause significant health challenges, particularly for individuals with comorbid conditions and older adults. However, information on the clinical manifestations and outcomes of adults hospitalized with RSV in Europe remains limited.METHODS: This multicenter observational cohort study of adults hospitalized with RSV or influenza A or B fro

Complex metabolic diseases due to overnutrition such as obesity, type 2 diabetes, and fatty liver disease are a major burden on the healthcare system worldwide. Current research primarily focuses on disease endpoints and trying to understand underlying mechanisms at relatively late stages of the diseases, when irreversible damage is already done. However, complex interactions between physiological

The partition of 125I-labelled pancreatic trypsin, chymotrypsin and elastase between the inhibitors, α2-macroglobulin f and s, α1-protease inhibitor, α2-antitrypsin, inter-α-trypsin inhibitor and the specific sow colostrum protease inhibitor, was studied in vitro by gradually increasing the concentration of these proteases in blood serum from adult and newborn pigs. As revealed by immunoelectropho

Substantial progress has been made in understanding the rate, the pathways, and the mechanisms regulating alveolar protein removal from the uninjured lung. Whole animal studies and cellular studies have demonstrated that the majority of alveolar epithelial protein clearance occurs by passive nondegradative diffusional pathways. Some evidence, however, has been recently presented that alveolar epit

Previous experiments by our group have demonstrated that total parenteral nutrition (TPN) in rats increases the gut permeability to FITC-dextran 70,000 when compared to normally fed controls. TPN may thus, by inducing a 'leaky' gut be one co-factor behind the development of 'gut origin sepsis', a recent hypothesis for the development of multiple organ failure (MOF) in patients subjected to severe

The present investigation characterized the effect of red kidney bean lectin exposure on gut maturation and function in young piglets. Eleven suckling pigs were given by stomach tube a crude red kidney bean lectin preparation (containing about 25% lectin, 400 mg/kg BW) (lectin-treated pigs) at 10, 11, and 12 d of life, and an additional 16 pigs (control pigs) were given saline instead. On the next

We report the presence of platelet-activating factor (PAF-acether; l-0-alkyl-2-acetyl-.v«-glycero-3-phosphocholine) in small-intestinal and colonic mucosa of neonatal rats. The PAF-acether content was higher in the colon than in the small intestine, and was lower in the small intestine of 30-day-old animals than in 14-day-old animals. We also report that cultured intestinal epithelial cells (INT 4

Satu Lähteenoja’s PhD thesis consists of five published articles and an extensive introduction. The articles make strong, or even major, contributions to research and Satu Lähteenoja’s contribution to the articles is clearly demonstrated. The introduction combines the articles into a whole and through the introduction the contribution is clearly bigger than the sum of the five articles.

Denna berättelse om immunoterapi kombinerad med ultrahypo-fraktionerad strålterapi har sitt ursprung i den kliniska studie som på engelska benämdes "Brain Immune Gene Tumour Therapy" (BRIGTT) som professor Leif G, Salford i Lund initierade strax innan 2000-millienium-skiftet. Ett specifikt tumörvaccin framställdes baserat på tumörceller som han extraherade ur tumörvävnad från den gliom-patient han

Background and purpose: Since patients with primary brain tumor are expected to become long-term survivors, the prevention of long-term treatment-induced side effects is particularly important. This study aimed to explore whether symptom experience and symptom distress change over five years in adults with primary brain tumors treated with proton therapy. An additional aim was to explore whether s

Background: Cortical contusions are common in moderate-severe traumatic brain injury (TBI). Cortical contusions often expand, potentially causing neuro-worsening several hours to days post-trauma. While contusion expansion (CE) may affect outcome, potential clinical and radiological markers that can predict CE have been insufficiently explored. In the present single-center retrospective observatio

The evidence-based analysis of people's navigation and wayfinding behaviour in large-scale built-up environments (e.g., hospitals, airports) encompasses the measurement and qualitative analysis of a range of aspects including people's visual perception in new and familiar surroundings, their decision-making procedures and intentions, the affordances of the environment itself, etc. In our research

Neuroblastoma exhibits two cellular phenotypes: therapy-sensitive adrenergic (ADRN) and therapy-resistant mesenchymal (MES). To understand treatment response, it is important to elucidate how these phenotypes impact the dynamics of cancer cell populations and whether they represent distinct cell types or dynamic cell states. Here, we use an integrated experimental and mathematical modeling approac

This chapter reflects on the need for a decolonial turn in Sweden’s foreign policy. The growing ecological emergencies that we are faced with call on us to recognise and address quite profound global inequities, many of which are rooted in histories of European colonialism. In a sprawling conversation about the coloniality of the global economy and Sweden’s role in it, the chapter addresses such t

A people-centred approach for designing large-scale built-up spaces necessitates systematic anticipation of user’s embodied visuo-locomotive experience from the viewpoint of human-environment interaction factors pertaining to aspects such as navigation, wayfinding, usability. In this context, we develop a behaviour-based visuo-locomotive complexity model that functions as a key correlate of cognit

Climate modeling suggests that achieving international climate goals requires a reduction in current CO2 emissions by over 90%, with any remaining emissions to be addressed through carbon dioxide removal (CDR) solutions. Sixteen CDR strategies are evaluated by integrating technical potential, environmental, social, and governance (ESG) criteria, along with sequestration permanence. This evaluation

Background: The spread of tau pathology closely correlates with the disease course and cognitive decline in Alzheimer’s disease (AD). Tau-targeting immunotherapies are being developed to stop the spread of tau pathology and thus halt disease progression. In this post hoc analysis of the ADAMANT clinical trial, we examined the performance of AADvac1, an active immunotherapy targeting the microtubul

The nonvolatile cryogenic memories can play an important role in realizing energy-efficient and scalable low-temperature electronics for quantum computing and future high-performance computing systems. In this article, we evaluate he cryogenic performance of HfOx-based resistive random access memory (RRAM) and demonstrate that the addition of extremely thin ∼0.5-nm AlOx barrier layers enables a h