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Elevations in plasma glucagon are associated with reduced insulin clearance after ingestion of a mixed-macronutrient meal in people with and without type 2 diabetes

Aims/hypothesis: The temporal suppression of insulin clearance after glucose ingestion is a key determinant of glucose tolerance for people without type 2 diabetes. Whether similar adaptations are observed after the ingestion of a mixed-macronutrient meal is unclear. Methods: In a secondary analysis of data derived from two randomised, controlled trials, we studied the temporal responses of insuli

Clinical guidelines for the management of mammographic density : a systematic review of breast screening guidelines worldwide

Background: High breast density is an independent risk factor for breast cancer and decreases the sensitivity of mammography. This systematic review synthesizes the international clinical guidelines and the evidence base for screening and supplemental screening recommendations in women with dense breasts. Methods: A systematic search of CINHAL, Embase, and Medline databases was performed in August

Novel insights into the cognitive, emotional, and experiential dimensions of stakeholder acceptance of wildlife management

Understanding wildlife stakeholders is vital in mitigating the risk for inertia in the implementation of management and illegal activities, e.g., poaching. We used a unique set of questionnaire data of stakeholders in Sweden (n = 8728) comprising birdwatchers, hunters, farmers, and the general public, to analyze evaluations of geese, beliefs about goose management at multiple levels, and acceptanc

3D Heisenberg universality in the van der Waals antiferromagnet NiPS3

Van der Waals (vdW) magnetic materials are comprised of layers of atomically thin sheets, making them ideal platforms for studying magnetism at the two-dimensional (2D) limit. These materials are at the center of a host of novel types of experiments, however, there are notably few pathways to directly probe their magnetic structure. We confirm the magnetic order within a single crystal of NiPS3 an

Surgical treatment and outcomes in aortic valve endocarditis and perivalvular abscesses

Patients with aortic root abscesses experience increased morbidity and mortality compared to those without abscess in aortic valve infective endocarditis. The superior intervention for patients with aortic root abscess is not determined. This research investigates the degree to which increased morbidity and mortality of aortic root abscess, and to describe perioperative characteristics and outcome

Practitioner Review : Assessment and treatment of body dysmorphic disorder in young people

Body dysmorphic disorder (BDD) is a relatively common and highly impairing mental disorder that is strikingly underdiagnosed and undertreated in Child and Adolescent Mental Health Services (CAMHS). The only clinical guidelines for the management of BDD in youth were published nearly 20 years ago, when empirical knowledge was sparse. Fortunately, there has been a surge in research into BDD over the

Pilotförsök för generell övervakning av pollinatörer – resultat för fältsäsongen 2022

Lunds universitet har på uppdrag av Naturvårdsverket under 2021–2022 utvärderat metodik för nationell pollinatörsövervakning. Metodiken bygger på rapporten ”Proposal for an EU pollinator monitoring scheme” som tagits fram av en expertgrupp inom EU och ska ge underlag för uppföljning av pollinatörer på nationell nivå med ett främsta fokus på landskapet utanför områden som omfattas av EU:s gemensamm

Cardiac biomarkers for detection of coronary artery disease in the community

To investigate whether coronary artery disease (CAD) burden is associated with plasma levels of the myocardial biomarkers Troponin I (TropI) and NT-proBNP in a large population-based sample using a cross-sectional design. Coronary computerized tomography (CT) angiography was performed in 25,859 subjects without a history of atherosclerotic disease from SCAPIS study (age 50-65, 52% women). TropI an

Preclinical exploration of the DNA damage response pathway using the interactive neuroblastoma cell line explorer CLEAN

Neuroblastoma (NB) is the most common cancer in infancy with an urgent need for more efficient targeted therapies. The development of novel (combinatorial) treatment strategies relies on extensive explorations of signaling perturbations in neuroblastoma cell lines, using RNA-Seq or other high throughput technologies (e.g. phosphoproteomics). This typically requires dedicated bioinformatics support

Patient characteristics in relation to opioid exposure in a chronic non-cancer pain population

OBJECTIVES: The efficacy of long-term opioid therapy (LTOT) in treating patients with chronic non-cancer pain (CnCP) is questionable, and the potential risks of adverse effects are well established. The aims were as follows: (1) compare characteristics in patients exposed to LTOT vs non-exposed. (2) Regarding opioid-exposed patients, describe characteristics of patients with risk factors for opioi

Surprising results of patch testing with the baseline series in patients with photocontact allergy to ketoprofen

Objective: Photoallergic reactions due to topical ketoprofen are common. As some simultaneous contact allergies have been described in the literature, we aimed to get an overview of the pattern of reactivity towards common allergens in the baseline series in ketoprofen-photoallergic individuals. Methods: Using our database, we found 94 patients with photocontact allergy to ketoprofen diagnosed dur

The work–recovery cycle of kidney strain and inflammation in sugarcane workers following repeat heat exposure at work and at home

Purpose: To examine heat exposure at work and home and the work–recovery cycle and temporal variation of kidney strain, muscle injury and inflammation biomarkers in sugarcane workers. Methods: 20 male sugarcane workers (age: 33 ± 7 years) with a workplace Rest.Shade.Hydration (RSH) intervention were observed over 4 days, at the end (18 h post-shift recovery) and beginning of a work week (42 h post

Right ventricular stroke work index from echocardiography in patients with pulmonary arterial hypertension-the role in short-term follow-up assessment

AimsRight ventricular (RV) failure causes high mortality in patients with pulmonary arterial hypertension (PAH). RV stroke work index (RVSWi) poses as a potential predictor of outcome. We evaluated how RVSWi by echocardiography (ECHO) or right heart catheterization (RHC) is altered following PAH treatment and if RVSWi is an indicator of outcome in PAH.Methods and resultsFifty-four patients with PA

Schizophrenia in children, adults and older people with intellectual disability compared with the general population: a Swedish register study (IDcare)

BACKGROUND: The knowledge about the prevalence of schizophrenia among people with intellectual disabilities (ID) is sparse, particularly concerning the distribution in different age groups.AIMS: To investigate the prevalence of diagnoses in the schizophrenia spectrum among people with ID compared with the general population (gPop).METHODS: This was an 8-year longitudinal register study. The partic

Men's Attitudes Towards Participation in Organised Prostate Cancer Testing: An Abductive Thematic Analysis

Background and objectiveOrganised prostate cancer (PCa) testing (OPT) was introduced in Sweden to gain knowledge in preparation for a potential national PCa screening programme. This study aims to explore men’s opinions regarding the OPT invitation letters and the attitudes influencing their decision to participate in or decline OPT.MethodsWe conducted semi-structured telephone interviews with 30