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Factors associated with cervical cancer screening among women living with HIV in the Kilimanjaro region, northern Tanzania : A cross-sectional study

Despite cervical cancer being a highly preventable disease, it is the fourth most common cancer among women in both incidence and mortality. Cervical cancer screening is crucial in preventing the disease. Women living with HIV (WLHIV) are at higher risk of cervical cancer because of their immune-compromised state. We aimed to determine factors associated with cervical cancer screening among WLHIV

Income inequality and carbon emissions in the United States 1929–2019

This paper studies the relationship between income inequality and carbon emissions in the United States between 1929 and 2019. We contribute to the literature by considering how the relationship have varied over time. To this end we estimate a band spectrum regression model and a smooth-varying coefficients model. Our results show that higher inequality was associated with lower emissions during tThis paper studies the relationship between income inequality and carbon emissions in the United States between 1929 and 2019. We contribute to the literature by studying if and how the relationship has varied over time. To this end we estimate a band spectrum regression model and a smooth-varying coefficients model. Our results show that higher inequality was associated with lower emissions durin

PcoB is a defense outer membrane protein that facilitates cellular uptake of copper

Copper (Cu) is one of the most abundant trace metals in all organisms, involved in a plethora of cellular processes. Yet elevated concentrations of the element are harmful, and interestingly prokaryotes are more sensitive for environmental Cu stress than humans. Various transport systems are present to maintain intracellular Cu homeostasis, including the prokaryotic plasmid-encoded multiprotein pc

Diagnosis and management of severe congenital protein C deficiency (SCPCD) : Communication from the SSC of the ISTH

Severe congenital protein C deficiency (SCPCD) is rare and there is currently substantial variation in the management of this condition. A joint project by three Scientific and Standardization Committees of the ISTH: Plasma Coagulation Inhibitors, Pediatric/Neonatal Thrombosis and Hemostasis, and Women’s Health Issues in Thrombosis and Hemostasis, was developed to review the current evidence and h

Biweekly fluctuations of neuropsychiatric symptoms according to the Neuropsychiatric Inventory : Erratic symptoms or scores?

Objectives: This study investigates the stability of neuropsychiatric symptoms (NPS) assessed biweekly using the Neuropsychiatric Inventory (NPI) in a memory clinic population during a 6 week period. Methods: Twenty-three spousal caregivers (mean [SD] age = 69.7 [8.8], 82.6% female) of 23 patients (43.5% had dementia) completed all assessments. The NPI was assessed four times during 6 weeks. We ex

Galectin-3 Decreases 4-1BBL Bioactivity by Crosslinking Soluble and Membrane Expressed 4-1BB

4-1BB is a T cell costimulatory receptor and a member of the tumor necrosis factor receptor superfamily. Here, we show that Galectin-3 (Gal-3) decreases the cellular response to its ligand (4-1BBL). Gal-3 binds to both soluble 4-1BB (s4-1BB) and membrane-bound 4-1BB (mem4-1BB), without blocking co-binding of 4-1BBL. In plasma, we detected complexes composed of 4-1BB and Gal-3 larger than 100 nm in

Nature-based solutions in an urban perspective

The traditional engineering approach to manage urban drainage is by combined or separated sewers. In urban catchments, drainage systems may include different types of storage and detention facilities to avoid flooding from heavy rainfall. However, during recent decades, alternative ways to manage floods have evolved since traditional methods often harm the riverine ecosystems by pollution and eros

Survivin Inhibition by Piperine Sensitizes Glioblastoma Cancer Stem Cells and Leads to Better Drug Response

Glioblastoma multiforme (GBM) cancer stem cells (GSCs) are one of the strongest contributing factors to treatment resistance in GBM. Identification of biomarkers capable of directly affecting these cells within the bulk tumor is a major challenge associated with the development of new targeting strategies. In this study, we focus on understanding the potential of the multifunctional extraordinaire

Stochastic models of Mendelian and reverse transcriptional inheritance in state-structured cancer populations

Recent evidence suggests that a polyaneuploid cancer cell (PACC) state may play a key role in the adaptation of cancer cells to stressful environments and in promoting therapeutic resistance. The PACC state allows cancer cells to pause cell division and to avoid DNA damage and programmed cell death. Transition to the PACC state may also lead to an increase in the cancer cell’s ability to generate

Plasma prostasin : a novel risk marker for incidence of diabetes and cancer mortality

Aims/hypothesis: Diabetes is associated with an increased risk of cancer. Prostasin is an epithelial sodium channel stimulator that has been associated with suppression of tumours, glucose metabolism and hyperglycaemia-associated tumour pathology. However, the association between prostasin, diabetes and cancer mortality has not been well investigated in humans. We aim to investigate the associatio

Emergency subtotal colectomy rates in relation to anti-TNF therapy in inflammatory bowel disease patients : comparison of retrospective cohorts

Objectives: The introduction of anti-TNF therapy has revolutionized the management of inflammatory bowel disease (IBD). This study aimed to investigate the impact of anti-TNF therapy on emergency subtotal colectomy rates in patients with IBD (ulcerative colitis, Crohn’s disease or indeterminate colitis) during two time periods. Methods: IBD patients treated with emergency subtotal colectomy for ac

Artificial virtuous agents in a multi‐agent tragedy of the commons

Although virtue ethics has repeatedly been proposed as a suitable framework for the development of artificial moral agents (AMAs), it has been proven difficult to approach from a computational perspective. In this work, we present the first technical implementation of artificial virtuous agents (AVAs) in moral simulations. First, we review previous conceptual and technical work in artificial virtu

Effects of the multicavity tip coolant injection on the blade tip and the over tip casing aerothermal performance in a high-pressure turbine cascade

In high performance gas turbine engines, the over tip leakage flow driven by the lateral pressure gradient is inevitably induced inside the blade tip gap in the high-pressure stage turbine due to the freestanding airfoil design methodology. To obtain an increasing level of thermal efficiency, the turbine inlet temperature is gradually increased in terms of the Brayton cycle. Hence, the blade tip a

Age, geochemistry, and origin of the mid-Proterozoic Häme mafic dyke swarm, southern Finland

We have reappraised the age and composition of the mid-Proterozoic Häme dyke swarm in southern Finland. The dominant trend of the dykes of this swarm is NW to WNW. Petrographic observations and geochemical data indicate uniform, tholeiitic low-Mg parental magmas for all of the dykes. Nevertheless, the variability in incompatible trace element ratios, such as Zr/Y and La/Nb, provides evidence of ch

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Novel rotating-cylinder sliding vane rotary compressors (RC-SVRCs) are promising machines in energy conversion systems due to extremely low friction. However, three-dimensional visual investigations on geometrical optimizations of RC-SVRCs are highly limited. Besides, most flow mechanisms and leakage flow affected by geometric structures have not been fully revealed yet. Therefore, the sliding van

Collaboration and Cities - Talking Transformations with Pourya Salehi (ICLEI Research)

We don’t just need action, we need informed action. That’s the ambition behind the global research and action agenda for cities. In this episode, we discuss collaborative urban research and what co-creating means in practice. We interview Pourya Salehi who is the Head of the Urban Research Team at ICLEI. He discusses the importance of informed decision-making, genuinely engaging cities in research

Spatiotemporal variation of soil water potential and its significance to water balance for a desert shrub area

In dry sandy soil, soil water is naturally redistributed by forces owing to matric and gravitational potential, and temperature gradients. Occurring shrub vegetation strongly influences these patterns by hydraulic redistribution within the soil. This means that plants can move water from moist to drier soil areas to extract nutrients from the drier soil and enhance nutrient uptake. This incorporat

Missions and Cities: Spotlight on Europe - Talking Transformations with Matthew Baldwin (European Commission)

The mission to the moon – an extraordinary achievement by humanity. But can we take that mission approach and apply it to cities? In this episode, we discuss the mission for 100 climate neutral cities in Europe by 2030. We interview Matthew Baldwin from the European Commission and the inaugural Mission Manager for the Mission on 100 Climate Neutral Cities. He gives a glimpse into the thinking behi